Timeline

Liliana Mancio Silva

Head of Structure

26 Apr 2024

publication

Autonomous circadian rhythms in the human hepatocyte regulate hepatic drug metabolism and inflammatory responses.

16 Jan 2024

event

DPT Parasites and Insects Vectors Seminar – Elena LEVASHINA : “Early stages of mosquito colonization by Plasmodium falciparum”

25 Apr 2023

news

World Malaria Day 2023: 2 lab articles highlighted by Cell Press

17 Feb 2023

publication

Hemisynthetic alkaloids derived from trilobine are antimalarials with sustained activity in multidrug-resistant Plasmodium falciparum.

11 Feb 2023

news

Celebrating Women And Girls In Science Day

31 Jan 2023

news

ERC Consolidator Grant awarded to study dormancy, relapse and sexual conversion in malaria parasites

11 Jan 2023

news

New publication: Hemisynthetic alkaloids derived from trilobine are antimalarials with sustained activity in multidrug-resistant Plasmodium falciparum

20 Dec 2022

event

Host-parasite metabolic interactions during malaria infection (HDR defense Liliana Mancio)

29 Sep 2022

publication

Repurposing of Plasmodium falciparum var genes beyond the blood stage.

07 Sep 2022

event

Symposium “Future in Parasitology 2022”

01 Sep 2022

news

Paludisme : recréer le cycle sanguin du parasite in vivo pour mieux lutter contre la maladie

25 Aug 2022

publication

Ebola virus infection induces a delayed type I IFN response in bystander cells and the shutdown of key liver genes in human iPSC-derived hepatocytes.

15 Jul 2022

news

New publication in Nature Communications: Humanized mice for sustained P. vivax blood-stage infection and transmission

15 Jul 2022

publication

Humanized mice for investigating sustained Plasmodium vivax blood-stage infections and transmission.

13 Jul 2022

publication

A single-cell liver atlas of Plasmodium vivax infection.

04 Jun 2022

news

New publication in Trends in Parasitology: Single cell views of the Plasmodium life cycle

04 Jun 2022

publication

Single-cell views of the Plasmodium life cycle.

01 Jun 2022

news

Our work featured @inserm

19 Apr 2022

news

New publication in Cell Host Microbe: A single-cell liver atlas of Plasmodium vivax infection

01 Oct 2021

publication

Linking microbiota composition with antimalarial antibody response.

02 Jul 2021

project

Host parasite metabolic interactions

07 Feb 2020

team

Plasmodium Infection and Transmission

21 Jan 2020

publication

Expansion, in vivo-ex vivo cycling, and genetic manipulation of primary human hepatocytes.

19 Dec 2019

publication

Targeting liver stage malaria with metformin.

14 May 2019

publication

γδ-T cells promote IFN-γ-dependent Plasmodium pathogenesis upon liver-stage infection.

01 May 2019

publication

Estrogen Activation of G-Protein-Coupled Estrogen Receptor 1 Regulates Phosphoinositide 3-Kinase and mTOR Signaling to Promote Liver Growth in Zebrafish and Proliferation of Human Hepatocytes.

04 Apr 2019

publication

Steroid Hormone Function Controls Non-competitive Plasmodium Development in Anopheles.

05 Mar 2019

publication

Improving Drug Discovery by Nucleic Acid Delivery in Engineered Human Microlivers.

14 Mar 2018

publication

In Vitro Culture, Drug Sensitivity, and Transcriptome of Plasmodium Vivax Hypnozoites.

01 Jan 2018

publication

Engineered Livers for Infectious Diseases.

01 Jan 2018

publication

Plasmodium UIS3 sequesters host LC3 to avoid elimination by autophagy in hepatocytes.

13 Jul 2017

publication

Nutrient sensing modulates malaria parasite virulence.

01 Feb 2017

publication

GLUT1-mediated glucose uptake plays a crucial role during Plasmodium hepatic infection.

06 Sep 2016

publication

Host AMPK Is a Modulator of Plasmodium Liver Infection.

07 Aug 2015

publication

One nanoprobe, two pathogens: gold nanoprobes multiplexing for point-of-care.

01 Apr 2015

publication

A mediator for malaria stickiness in A versus O blood.

01 Jan 2013

publication

Sir2a regulates rDNA transcription and multiplication rate in the human malaria parasite Plasmodium falciparum.

01 Jan 2013

publication

In situ fluorescence visualization of transcription sites and genomic Loci in blood stages of Plasmodium falciparum.

01 Sep 2012

publication

Two long non-coding RNAs generated from subtelomeric regions accumulate in a novel perinuclear compartment in Plasmodium falciparum.

01 Aug 2012

publication

B7-CD28 costimulatory signals control the survival and proliferation of murine and human γδ T cells via IL-2 production.

01 Mar 2012

publication

A novel carbon monoxide-releasing molecule fully protects mice from severe malaria.

24 Aug 2010

publication

Clustering of dispersed ribosomal DNA and its role in gene regulation and chromosome-end associations in malaria parasites.

01 May 2009

publication

Plasmodium falciparum heterochromatin protein 1 binds to tri-methylated histone 3 lysine 9 and is linked to mutually exclusive expression of var genes.

14 Apr 2009

publication

Sir2 paralogues cooperate to regulate virulence genes and antigenic variation in Plasmodium falciparum

01 Mar 2009

publication

Differential sub-nuclear localisation of repressive and activating histone methyl modifications in P. falciparum.

19 Feb 2009

publication

Genome-wide analysis of heterochromatin associates clonally variant gene regulation with perinuclear repressive centers in malaria parasites.

15 Jun 2008

publication

Differential association of Orc1 and Sir2 proteins to telomeric domains in Plasmodium falciparum.

08 Apr 2005

publication

Telomeric heterochromatin propagation and histone acetylation control mutually exclusive expression of antigenic variation genes in malaria parasites.

01 Jan 2005

publication

A little guide for advanced search:

Autonomous circadian rhythms in the human hepatocyte regulate hepatic drug metabolism and inflammatory responses.

DPT Parasites and Insects Vectors Seminar – Elena LEVASHINA : “Early stages of mosquito colonization by Plasmodium falciparum”

World Malaria Day 2023: 2 lab articles highlighted by Cell Press

Hemisynthetic alkaloids derived from trilobine are antimalarials with sustained activity in multidrug-resistant Plasmodium falciparum.

Celebrating Women And Girls In Science Day

ERC Consolidator Grant awarded to study dormancy, relapse and sexual conversion in malaria parasites

New publication: Hemisynthetic alkaloids derived from trilobine are antimalarials with sustained activity in multidrug-resistant Plasmodium falciparum

Host-parasite metabolic interactions during malaria infection (HDR defense Liliana Mancio)

Repurposing of Plasmodium falciparum var genes beyond the blood stage.

Symposium “Future in Parasitology 2022”

Paludisme : recréer le cycle sanguin du parasite in vivo pour mieux lutter contre la maladie

Ebola virus infection induces a delayed type I IFN response in bystander cells and the shutdown of key liver genes in human iPSC-derived hepatocytes.

New publication in Nature Communications: Humanized mice for sustained P. vivax blood-stage infection and transmission

Humanized mice for investigating sustained Plasmodium vivax blood-stage infections and transmission.

A single-cell liver atlas of Plasmodium vivax infection.

New publication in Trends in Parasitology: Single cell views of the Plasmodium life cycle

Single-cell views of the Plasmodium life cycle.

Our work featured @inserm

New publication in Cell Host Microbe: A single-cell liver atlas of Plasmodium vivax infection

Linking microbiota composition with antimalarial antibody response.

Host parasite metabolic interactions

Plasmodium Infection and Transmission

Expansion, in vivo-ex vivo cycling, and genetic manipulation of primary human hepatocytes.

Targeting liver stage malaria with metformin.

γδ-T cells promote IFN-γ-dependent Plasmodium pathogenesis upon liver-stage infection.

Estrogen Activation of G-Protein-Coupled Estrogen Receptor 1 Regulates Phosphoinositide 3-Kinase and mTOR Signaling to Promote Liver Growth in Zebrafish and Proliferation of Human Hepatocytes.

Steroid Hormone Function Controls Non-competitive Plasmodium Development in Anopheles.

Improving Drug Discovery by Nucleic Acid Delivery in Engineered Human Microlivers.

In Vitro Culture, Drug Sensitivity, and Transcriptome of Plasmodium Vivax Hypnozoites.

Engineered Livers for Infectious Diseases.

Plasmodium UIS3 sequesters host LC3 to avoid elimination by autophagy in hepatocytes.

Nutrient sensing modulates malaria parasite virulence.

GLUT1-mediated glucose uptake plays a crucial role during Plasmodium hepatic infection.

Host AMPK Is a Modulator of Plasmodium Liver Infection.

One nanoprobe, two pathogens: gold nanoprobes multiplexing for point-of-care.

A mediator for malaria stickiness in A versus O blood.

Sir2a regulates rDNA transcription and multiplication rate in the human malaria parasite Plasmodium falciparum.

In situ fluorescence visualization of transcription sites and genomic Loci in blood stages of Plasmodium falciparum.

Two long non-coding RNAs generated from subtelomeric regions accumulate in a novel perinuclear compartment in Plasmodium falciparum.

B7-CD28 costimulatory signals control the survival and proliferation of murine and human γδ T cells via IL-2 production.

A novel carbon monoxide-releasing molecule fully protects mice from severe malaria.

Clustering of dispersed ribosomal DNA and its role in gene regulation and chromosome-end associations in malaria parasites.

Plasmodium falciparum heterochromatin protein 1 binds to tri-methylated histone 3 lysine 9 and is linked to mutually exclusive expression of var genes.

Sir2 paralogues cooperate to regulate virulence genes and antigenic variation in Plasmodium falciparum

Differential sub-nuclear localisation of repressive and activating histone methyl modifications in P. falciparum.

Genome-wide analysis of heterochromatin associates clonally variant gene regulation with perinuclear repressive centers in malaria parasites.

Differential association of Orc1 and Sir2 proteins to telomeric domains in Plasmodium falciparum.

Telomeric heterochromatin propagation and histone acetylation control mutually exclusive expression of antigenic variation genes in malaria parasites.

The unusually large Plasmodium telomerase reverse-transcriptase localizes in a discrete compartment associated with the nucleolus.