Click to view graph
Click to view timeline
Background and Rationale
Jean-Christophe Barale (PI)
Despite the immense and encouraging progresses made over the last decade, malaria remains a major public health concern. Intensifying efforts against malaria along with an unprecedented increase in public and private funding have […]
2022Prevalence and characterization of piperaquine, mefloquine and artemisinin derivatives triple-resistant Plasmodium falciparum in Cambodia., J Antimicrob Chemother 2022 Dec; (): .
2022Human peroxiredoxin 6 is essential for malaria parasites and provides a host-based drug target., Cell Rep 2022 Jun; 39(11): 110923.
2014Computational design of protein-based inhibitors of Plasmodium vivax subtilisin-like 1 protease, PLoS ONE 2014;9(10):e109269.
2014A small-molecule cell-based screen led to the identification of biphenylimidazoazines with highly potent and broad-spectrum anti-apicomplexan activity, Eur J Med Chem 2015 Jan;89:386-400.
2014A novel Plasmodium-specific prodomain fold regulates the malaria drug target SUB1 subtilase, Nat Commun 2014 Sep;5:4833.
2014Cytometric measurement of in vitro inhibition of Plasmodium falciparum field isolates by drugs: a new approach for re-invasion inhibition study, Malar. J. 2014;13:110.
2014Whole Pichia pastoris yeast expressing measles virus nucleoprotein as a production and delivery system to multimerize Plasmodium antigens., PLoS One 2014 ; 9(1): e86658.
2013A molecular marker of artemisinin-resistant Plasmodium falciparum malaria, Nature 2014 Jan;505(7481):50-5.
2013In Silico screening on the three-dimensional model of the Plasmodium vivax SUB1 protease leads to the validation of a novel anti-parasite compound, J. Biol. Chem. 2013 Jun;288(25):18561-73.
2013Screening and evaluation of inhibitors of Plasmodium falciparum merozoite egress and invasion using cytometry, Methods Mol. Biol. 2013;923:523-34.
+View full list of publications