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© K. Melican.
Human microvessel (red) colonized by N. meningitidis (green).
Publication : Microbiology spectrum

The Many Faces of Bacterium-Endothelium Interactions during Systemic Infections

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Microbiology spectrum - 01 Mar 2019

Obino D, Duménil G

Link to Pubmed [PMID] – 30848239

Microbiol Spectr 2019 03;7(2)

A wide variety of pathogens reach the circulatory system during viral, parasitic, fungal, and bacterial infections, causing clinically diverse pathologies. Such systemic infections are usually severe and frequently life-threatening despite intensive care, in particular during the age of antibiotic resistance. Because of its position at the interface between the blood and the rest of the organism, the endothelium plays a central role during these infections. Using several examples of systemic infections, we explore the diversity of interactions between pathogens and the endothelium. These examples reveal that bacterial pathogens target specific vascular beds and affect most aspects of endothelial cell biology, ranging from cellular junction stability to endothelial cell proliferation and inflammation.

https://www.ncbi.nlm.nih.gov/pubmed/30848239