- Since 2001 to 2007: In charge of the core facilities of Cryo-EM,
- 2007- to day, Engineer d’Etude hors classe, CNRS, at the PFMU
Biophysical characterization of the translocation process of Bordetella pertussis adenylate cyclase toxin CyaA
This project aims to describe the hydrodynamic and thermodynamic properties of the CyaA toxin and the conformational changes it undergoes during its translocation process across the lipid membranes of Bordetella pertussis (secretion) and of […]
CyaA secretion, folding and translocation across membrane
CyaA, a 1706 residue-long protein, is one of the major virulence factors produced by B. pertussis and plays an important role in the early stages of respiratory tract colonization. This toxin uses an original […]
Bacterial Transmembrane Signaling
Bacteria display several mechanisms to adapt to their host-environment and successfully colonise it. One important mechanism of adaptation concerns the regulation of gene expression in response to external signals such as the presence of […]
2017A novel type of polyhedral viruses infecting hyperthermophilic archaea, J. Virol. 2017 Jun 9;91(13):e00589-17.
2017The Ancient Gamete Fusogen HAP2 Is a Eukaryotic Class II Fusion Protein., Cell. 2017 Feb 23;168(5):904-915.e10. doi: 10.1016/j.cell.2017.01.024..
2016Structural basis of the signaling through a bacterial membrane receptor HasR deciphered by an integrative approach., Biochem J. 2016 May 13. pii: BCJ20160131.