Signatures microARNs cellulaires dans la sclérose en plaques -SEP-MIR
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TYK2 variants in cytokine signaling and autoimmune diseases
TYK2 belongs to the Janus/JAK family of protein tyrosine kinases and is involved in signaling of immunoregulatory cytokines (type I and type III IFNs, IL-6, IL-10 and IL-12 families) that contribute to a balanced […]
Cellular and molecular immunoprofiling of multiple sclerosis patients
This project aims at providing new knowledge on the immunomodulatory effect of IFN-I in multiple sclerosis patients by using state-of-the-art technologies. An important challenge is the identification of cellular and molecular biomarkers of IFN […]
Role of IFN-I in the development of IL-10-producing CD4 T cells
We have shown that IFN-I promotes development of human type 1 regulatory-like cells (Tr1) that produce the anti-inflammatory cytokine IL-10, and have studied the integration of T cell receptor (TCR) signal strength and CD28 […]
2023Central Role of Macrophages and Nucleic Acid Release in Myasthenia Gravis Thymus., Ann Neurol 2023 Apr; 93(4): 643-654.
2022IFN-I inducible miR-3614-5p targets ADAR1 isoforms and fine tunes innate immune activation., Front Immunol 2022 ; 13(): 939907.
2021Altered Immune Phenotypes and HLA-DQB1 Gene Variation in Multiple Sclerosis Patients Failing Interferon β Treatment., Front Immunol 2021 ; 12(): 628375.
2020Two common disease-associated TYK2 variants impact exon splicing and TYK2 dosage., PLoS One 2020 ; 15(1): e0225289.
2020Human Ubiquitin-Specific Peptidase 18 Is Regulated by microRNAs via the 3’Untranslated Region, A Sequence Duplicated in Long Intergenic Non-coding RNA Genes Residing in chr22q11.21., Front Genet 2020 ; 11(): 627007.
2019Expression of endogenous retroviruses reflects increased usage of atypical enhancers in T cells, EMBO J. 2019 May;.
2017Type I interferon-enhanced IL-10 expression in human CD4 T cells is regulated by STAT3, STAT2, and BATF transcription factors, J. Leukoc. Biol. 2017 05;101(5):1181-1190.
2013Type I interferon potentiates T-cell receptor mediated induction of IL-10-producing CD4⁺ T cells, Eur. J. Immunol. 2013 Oct;43(10):2730-40.
2013Two rare disease-associated Tyk2 variants are catalytically impaired but signaling competent., J Immunol 2013 Mar; 190(5): 2335-44.
2012A conserved polylysine motif in CD86 cytoplasmic tail is necessary for cytoskeletal association and effective co-stimulation., Biochem Biophys Res Commun 2012 Jun; 423(2): 301-7.
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