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© Biologie structurale et chimie
Structure du domaine en doigt de zinc de la protéine NEMO, déterminée par Résonance magnétique nucléaire (RMN). Cette protéine jouant un rôle dans des maladies (cancer, inflammation), les connaissances acquises sur sa structure offrent de précieuses informations sur sa fonction.
Scientific Fields
Diseases
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About

            Fabrice Agou received his doctorate in Biochemistry/Enzymology from University Paris 11 (Orsay) and defended his HDR from University Paris 6. He began his scientific career in the laboratory of J.P. Waller (CNRS, Gif sur Yvette, France), who founded the first Biochemistry laboratory at Ecole Polytechnique. Fabrice did his thesis work on a multi-protein complex composed of several aminoacy-tRNA synthetases (aaRS). In collaboration with E.Guittet and J. Lepault (CNRS, Gif sur Yvette, France), he also became acquainted with NMR and transmission electron cryo/microscopy techniques. When J.P. Waller retired in 1995, he joined M. Mirande ‘s team (CNRS, Gif sur Yvette, France) to carry out his first post-doctoral fellowship. There he initiated genetic studies in yeast and mammals and expanded his knowledge of RNA:protein interactions by investigating different aaRss. In 1997, he joined the laboratory of M. Véron at the Institut Pasteur, first as a Post-Doc and then as a “Chargé de Recherche”. His work initially focused on the DNA binding properties of eukaryote nucleoside diphosphate kinases (NDPK), and their role in transcription.

During this period, he realized that to truly tackle fundamental questions in biology a double competency in structural biology and cellular biology was necessary. He put this philosophy into practice in 1998, when he started a collaboration with Alain Israël on the NEMO (NF-kB Essential MOdulator) protein, to the extent that in 2005, he set up an autonomous group exclusively dedicated to its study. Since 2005, his group used a host of structural biology and cellular biology techniques to elucidate NEMO’s role in the regulation of IKK complex signalling and two human pathologies termed incontinentia pigmenti and anhidrotic ectodermal dysplasia with immunodefiency (EDA-ID), respectively. To this end, he also initiated collaborations with JL Casanova (Rockefeller, New York and IMAGINE Institute, Necker Hospital for Sick Children, France) and A Munnich (IMAGINE Institute, Necker Hospital for Sick Children, France) who are internationally recognized specialists in these rare human diseases. His lab’s applied/clinical research efforts had begun in 2004 when he discovered the first generation of NEMO peptide inhibitor of the NF-kB pathway. This led to industrial collaborations that were assisted by the DARRI (Pasteur Technology Transfer department). Fabrice successfully developed advanced methods in cristallogenesis (DARPin, protein engineering), directed evolution (ribosome display), peptidomimetics as well as strategies aiming at in vivo incorporation of photoactivable amino acid into protein. In addition to his work in the laboratory, for the last ten years, he has also taught graduate courses at the Master 2 and L3 levels at the University Paris 6 and the Ecole Normale Supérieure (Paris), respectively.

Since 2015, Fabrice started as the head of the chemogenomic and biological screening core facility to provide target-based, cell-based and phenotypic screening supports for research teams at the Institut Pasteur.

Events

Scientific Day on Genome Editing Technology : CRISPR-Cas9 Seminar

Building: Monod (66) – Room: Amphithéâtre – Address: Institut Pasteur, Paris, France
2016-02-11 10:00:00 2016-02-11 00:00:00 Europe/Paris Scientific Day on Genome Editing Technology : CRISPR-Cas9 Seminar 10:00 – 11:00 : Fundamental and innovations in CRISPR-Cas9 gene editing James Goldmeyer, PhD, Product Manager GE Healthcare Dharmacon 11:00 – 11:30 : iCRISPR: inducible editing in stem cells and their derivatives Janine Scholefield, […] Institut Pasteur, Paris, France

Advancing scientific innovations with ECHO Acoustic Liquid Handling

Building: Lwoff – Room: RDC-14/15 – Address: Institut Pasteur, Paris, France
2016-04-15 09:30:00 2016-04-15 16:00:00 Europe/Paris Advancing scientific innovations with ECHO Acoustic Liquid Handling 9,45 – 10,30 : Acoustic Dispensing Usage for Drug Discovery in the CRUK Cancer Therapetics Unit. Dr Rosemary Burke, Senior Researcher Hit Discovery and Structural Design Team, CRUK London 10,45 – 11,30 : Single […] Institut Pasteur, Paris, France

The power of CRISPR-Cas9 arrayed screen using synthetic crRNA libraries

Building: Monod (66) – Room: Amphithéâtre – Address: Institut Pasteur, Paris, France
2017-03-15 10:00:00 2017-03-15 00:00:00 Europe/Paris The power of CRISPR-Cas9 arrayed screen using synthetic crRNA libraries CRISPR-Cas9 is a powerful tool for loss-of-function analysis, and to date has been adopted for large-scale functional screening primarily in the form of pooled sgRNA libraries. However, pooled screening is limited to enrichment or […] Institut Pasteur, Paris, France

Publications