Fabienne Levi-Acobas

Les bactéries à Gram négatif sont entourées d’une enveloppe composée de deux membranes (les membranes dites externe et interne) séparées par l’espace périplasmique. Cette enveloppe contient des machines macromoléculaires qui assurent et régulent les […]

Expanding the genetic code beyond the A-T/G-C Watson-Crick canonical base pairs and 20 amino acids of natural organisms is a long standing goal in synthetic biology. Reprogrammation of the genetic code can lead to […]

An important research axis of the laboratory is to modify nucleic acids with chemical groups in order to improve their therapeutic usefulness. Particularly, modified aptamers (i.e. oligonucleotides capable of binding to targets with high […]

Functional nucleic acids (aptamers, DNAzymes, ribozymes, and aptazymes) are generated by in vitro Darwinian evolution methods (SELEX and related methods of in vitro selection). We are interested to expand the capacity of these functional […]