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About

Eliane Meurs  has a solid expertise on signaling pathways leading to induction of IFN and on the mechanism of action of the dsRNA-dependent protein kinase PKR. E.Meurs was originally responsible for the cloning of this kinase which opened the door to its study, worldwide. She was also pionneer in demonstrating that PKR modulates signaling pathways involved in inflammation. PKR is now emerging as an important kinase related to stress. Current studies of the team focus on the modulation of several signalling pathways by viral infections such as Hepatitis C virus linked to autophagy, deregulation of lipid metabolism and insulin resistance. The team investigates also the role of PKR in stress-associated neurodegenerative diseases such as Alzheimer disease and is generating novel PKR inhibitors through screening of chemical compound libraries.

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