Eliane Meurs has a solid expertise on signaling pathways leading to induction of IFN and on the mechanism of action of the dsRNA-dependent protein kinase PKR. E.Meurs was originally responsible for the cloning of this kinase which opened the door to its study, worldwide. She was also pionneer in demonstrating that PKR modulates signaling pathways involved in inflammation. PKR is now emerging as an important kinase related to stress. Current studies of the team focus on the modulation of several signalling pathways by viral infections such as Hepatitis C virus linked to autophagy, deregulation of lipid metabolism and insulin resistance. The team investigates also the role of PKR in stress-associated neurodegenerative diseases such as Alzheimer disease and is generating novel PKR inhibitors through screening of chemical compound libraries.
Click to view graph
Connections
Click to view timeline
Timeline
Projects
Publications
Download-
2020RIG-I and PKR, but not stress granules, mediate the pro-inflammatory response to yellow fever virus., J. Virol. 2020 Sep; (): .
-
2017Inhibition of the inflammatory response to stress by targeting interaction between PKR and its cellular activator PACT, Sci Rep. 2017 Nov 23;7(1):16129.
-
2015Increased levels of cerebrospinal fluid JNK3 associated with amyloid pathology: links to cognitive decline, J Psychiatry Neurosci 2015 May;40(3):151-61.
-
2014HIV-1 translation and its regulation by cellular factors PKR and PACT, Virus Res. 2014 Nov;193:65-77.
-
2012dsRNA-dependent protein kinase PKR and its role in stress, signaling and HCV infection, Viruses 2012 Nov;4(11):2598-635.
-
2011Hepatitis C virus reveals a novel early control in acute immune response, PLoS Pathog. 2011 Oct;7(10):e1002289.
-
2010Hepatitis C virus controls interferon production through PKR activation, PLoS ONE 2010;5(5):e10575.
-
2010ER targeting and retention of the HCV NS4B protein relies on the concerted action of multiple structural features including its transmembrane domains, Mol. Membr. Biol. 2010 Jan;27(1):45-62.
-
2009Polo-like kinase 1 (PLK1) regulates interferon (IFN) induction by MAVS, J. Biol. Chem. 2009 Aug;284(33):21797-809.
-
2007Lipoprotein lipase mediates hepatitis C virus (HCV) cell entry and inhibits HCV infection, Cell. Microbiol. 2007 Oct;9(10):2445-56.
-
+View full list of publications