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Projets
CV
(EN)
EDUCATION
- 2018: “Habilitation à Diriger des Recherches”, Paris Descartes University, France
- 1998: PhD in Biochemistry and Molecular Biology, USTL-Montpellier II, France.
- 1994: Master degree in Biochemistry and Applied Biology at the University of Caen, and microbiology and in Food Science at the university of Montpellier II, France.
- 1992: Bachelor degree in Biology and Biochemistry at the University of Caen.
- 1990: Technical degree in Applied Biology at the University of Technology in Caen.
FIELD OF EXPERTISE
- Parasitology, Infection diseases, Host-pathogen interactions and Translational research.
RESEARCH and PROFESSIONAL EXPERIENCE
- 2015-now. Senior researcher and Team leader of Molecular parasitology, PARSIG Unit, Institut Pasteur & INSERM U1201, Paris.
- 2017. Visiting Scientist at IP Shanghai, China
- 2012-2015. Researcher, PARSIG Unit, Institut Pasteur & INSERM U1201, Paris.
- 2009-2011. Researcher, USR3151, station biologique de Roscoff, CNRS, Roscoff.
- 2006-2009. Postdoc, Paterson Institute for Cancer Research, Unit of Cell Division. University of Manchester, UK.
- 1999-2005. Postdoc, School of Life Sciences, Division of Gene Expression and Regulation. Laboratoiry of Prof. M.J.R. Stark. University of Dundee, UK.
- 1998-1999. Lecturer, ENSA-Montpellier. Laboratoire de Biochimie Métabolique et de Technologie, IPV-INRA Montpellier.
SCIENTIFIC ACTIVITIES, RESPONSABILITIES & EXPERTISES
- 20 publications, Hirsch h index: 12 (total citations: 2429).
- Scientific coordination: 2014-2018: ANR-TranSig, Trans-signalling: A novel mechanism of Leishmania host cell immune evasion through the release of parasite signalling proteins.
- Scientific co-coordination: 2012-2016: ANR-TransLeish (www.transleish.org), “Discovery of druggable protein kinases in the protozoan parasite Leishmania donovani using hit compounds identified by phenotypic screening”.
- Collaborations : Laurent Meijer (ManRos, Roscoff), Joachim Clos (Hambourg), Uwe Knippschild (Ulm), Pascal Marchand (Nantes), Sandrine Cojean (Paris Sud), Damarys Loew (Institut Curie) & Florent Dingli (Institut Curie).
- Member of organising committee : Labex IBEID international symposium : Can one anticipate the next emerging infectious diseases in Europe?, Paris (2014). PIV international conference: CRISPR in parasitology, Paris(2018).
- Member of the editorial board of « Frontiers in Cellular and Infection Microbiology ».
- Reviewer for PLoS one, Medchemcomm, cellular microbiology, Biochemical pharmacology, PLoS NTD, Molecules, Experimental parasitology, journal of cellular biochemistry, and ACS infectious diseases, AAC, Molecular Microbiology.
- Grant reviewer for CAPES-COFECUB, Fwo and Fiocruz-Pasteur. Member of PhD theses jury: 3.
- Responsabilities: member of the bureau of the “collège chercheur de l’Institut Pasteur”.
- Supervision of 9 students, 4 PhD students (3 in co-supervision), 2 postdocs, 1 senior scientist, 1 technician and 1 engineer.
AWARDS-FUNDINGS
- 2012-2016: Co-coordinator ANR TranLeish consortium.
- 2014-2018: Coordinator ANR TranSig consortium.
- 2015: PhD grant from the Labex IBEID.
- 2002-2005: Fellow of the Welcome Trust (UK).
- 1994-1998: Fellow of the Ministry of Education and Research (France).
TEACHING ACTIVITIES
- Since 2013: Lecturer in Master 1, Basic and medical parasitology/mycology, UPMC Sorbonne universities & Lecturer in Master 2, parasitology, UPMC Sorbonne universities.
- 2013-2015: Lecturer in Master 1, UE Agents infectieux, University of Versailles.
- 2015: Sanofi parasitology training, invited as an expert in drug discovery for Leishmaniasis. 2016-2018: Tutoring PhD student.
- Since 2012: Member of the coordination team of the Master 2 of sciences and technologies, option molecular and cellular biology, UPMC, Sorbonne universities, headed by Dominique Mazier.
- 2017: Lecturer at the international course “Teaching Asia Pacific Pasteur Institute Network (TAPPIN)”, Institut Pasteur of Shanghai, China.
Publications
Télécharger-
2017Characterisation of Casein Kinase 1.1 in Using the CRISPR Cas9 Toolkit, Biomed Res Int 2017;2017:4635605.
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2017The enemy within: Targeting host-parasite interaction for antileishmanial drug discovery, PLoS Negl Trop Dis 2017 Jun;11(6):e0005480.
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2016Species- and Strain-Specific Adaptation of the HSP70 Super Family in Pathogenic Trypanosomatids, Genome Biol Evol 2016 07;8(6):1980-95.
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2016From Drug Screening to Target Deconvolution: a Target-Based Drug Discovery Pipeline Using Leishmania Casein Kinase 1 Isoform 2 To Identify Compounds with Antileishmanial Activity, Antimicrob. Agents Chemother. 2016 05;60(5):2822-33.
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2015A touch of Zen: post-translational regulation of the Leishmania stress response, Cell. Microbiol. 2015 May;17(5):632-8.
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2014Transgenic analysis of the Leishmania MAP kinase MPK10 reveals an auto-inhibitory mechanism crucial for stage-regulated activity and parasite viability, PLoS Pathog. 2014 Sep;10(9):e1004347.
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2014Probing druggability and biological function of essential proteins in Leishmania combining facilitated null mutant and plasmid shuffle analyses, Mol. Microbiol. 2014 Jul;93(1):146-66.
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2014Phosphorylation of Sli15 by Ipl1 is important for proper CPC localization and chromosome stability in Saccharomyces cerevisiae, PLoS ONE 2014;9(2):e89399.
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2013Pharmacological assessment defines Leishmania donovani casein kinase 1 as a drug target and reveals important functions in parasite viability and intracellular infection, Antimicrob. Agents Chemother. 2014;58(3):1501-15.
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2012Apoptotic marker expression in the absence of cell death in staurosporine-treated Leishmania donovani, Antimicrob. Agents Chemother. 2013 Mar;57(3):1252-61.
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