Research Engineer at the platform Biophysics of Macromolecules and their interactions facility, in charge of the spectroscopic line with circular dichroism device, stationary phase and stopped-flow fluorimetry, thermophoresis. The responsibility includes the training of new users, the maintenance and know-how of material, the understanding of the technology allowing the monitoring of short, medium and long term interaction with researchers, beginners or experts who need to complete their studies by biophysical measurements.
Biophysical characterization of the translocation process of Bordetella pertussis adenylate cyclase toxin CyaA
This project aims to describe the hydrodynamic and thermodynamic properties of the CyaA toxin and the conformational changes it undergoes during its translocation process across the lipid membranes of Bordetella pertussis (secretion) and of […]
CyaA secretion, folding and translocation across membrane
CyaA, a 1706 residue-long protein, is one of the major virulence factors produced by B. pertussis and plays an important role in the early stages of respiratory tract colonization. This toxin uses an original […]
2017Facile immobilization of DNA using an enzymatic his-tag mimic, Chem. Commun., 2017, 53, 13031-13034.
2016The Translocation Domain of Botulinum Neurotoxin A Moderates the Propensity of the Catalytic Domain to Interact with Membranes at Acidic pH, PLoS ONE 2016;11(4):e0153401.
2016The Tip of the Four N-Terminal α-Helices of Clostridium sordellii Lethal Toxin Contains the Interaction Site with Membrane Phosphatidylserine Facilitating Small GTPases Glucosylation, Toxins (Basel) 2016 Mar;8(4):90.
2016Neurotoxic phospholipase A2 from rattlesnake as a new ligand and new regulator of prokaryotic receptor GLIC (proton-gated ion channel from G. violaceus), Toxicon 2016 Jun;116:63-71.
2015A Druggable Pocket at the Nucleocapsid/Phosphoprotein Interaction Site of Human Respiratory Syncytial Virus, J. Virol. 2015 Nov;89(21):11129-43.