Search anything and hit enter
  • Teams
  • Members
  • Projects
  • Events
  • Calls
  • Jobs
  • publications
  • Software
  • Tools
  • Network
  • Equipment

A little guide for advanced search:

  • Tip 1. You can use quotes "" to search for an exact expression.
    Example: "cell division"
  • Tip 2. You can use + symbol to restrict results containing all words.
    Example: +cell +stem
  • Tip 3. You can use + and - symbols to force inclusion or exclusion of specific words.
    Example: +cell -stem
e.g. searching for members in projects tagged cancer
Search for
Count
IN
OUT
Content 1
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Clinical Research Nurse
  • Clinician Researcher
  • Department Manager
  • Dual-education Student
  • Full Professor
  • Honorary Professor
  • Lab assistant
  • Master Student
  • Non-permanent Researcher
  • Nursing Staff
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Prize
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Content 2
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Clinical Research Nurse
  • Clinician Researcher
  • Department Manager
  • Dual-education Student
  • Full Professor
  • Honorary Professor
  • Lab assistant
  • Master Student
  • Non-permanent Researcher
  • Nursing Staff
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Prize
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Search
Go back
Scroll to top
Share
© Valérie Choumet
Mosquitoes were orally infected with the chikungunya virus. Midguts were dissected at day 5 post-infection, fixed and permeabilised. Virus is shown in red (anti-E2 protein, cyanine 3), the actin network in green (phalloidin 548) and nuclei in blue (DAPI).
Scientific Fields
Diseases
Organisms
Applications
Technique
Application Deadline
01
Sep 2021
2021-09-01 8:00:00 2021-09-01 18:00:00 Europe/Paris Postdoc position for the synthesis of carbohydrate-siRNA therapeutic oligonucleotides Design, synthesis and evaluation of carbohydrate-siRNA chimeras as novel therapeutic agents A postdoc position for a talented postdoctoral researcher is available in the Chemistry of Biomolecules and Bioorganic Chemistry of Nucleic Acids units at […] "25-28 rue du Dr. Roux, 75015, Paris" Laurence Mulard laurence.mulard@pasteur.fr

Design, synthesis and evaluation of carbohydrate-siRNA chimeras as novel therapeutic agents

A postdoc position for a talented postdoctoral researcher is available in the Chemistry of Biomolecules and Bioorganic Chemistry of Nucleic Acids units at the Institut Pasteur, Paris, France.

Topic. The advent of mRNA-based vaccines against SARS-Covid 2 and the FDA-approval of numerous therapeutic siRNA oligonucleotides clearly underscore the importance of oligonucleotide-based therapeutic agents. In this project, we aim to achieve the proof-of-concept for an innovative strategy to produce original RNA-like molecules featuring improved biological properties for use as therapeutics. Interfacing siRNA and anti-mRNA manipulation with RNA-based imaging, the poposal takes advantage of the versatility of chemical synthesis, and in particular of glycochemistry.

Representative publications: Chem Eur J 2021, 27, 5694-711. doi: 10.1002/chem.202003480 ; Proc. Natl. Acad. Sci. U.S.A. 2020, 117, 16790-16798; doi: 10.1073/pnas.2003267117

Profile. A PhD in organic chemistry with experience in the synthesis of carbohydrates and analogs and/or in the synthesis of nucleoside and nucleotide analogs, particularly in solid-phase synthesis using modified phosphoramidites. A proven record of achievements, good communication skills, autonomy and a strong propensity for team work would be assets.

Conditions. The position is funded by the « Direction des applications de la Recherche et des Partenariats Industriels (DARRI) » of the Institut Pasteur and the Institut Carnot. The salary corresponds to the postdoc standard in France, including extended health coverage. The contract will be for 24 months. The position is available from September 2021, but the exact starting date is negotiable (within the last trimester of 2021).

Application: Send a single pdf document with a detailed CV, a cover letter, and the names and contacts of three references.

Materials should be emailed to the principal investigators Laurence Mulard (laurence.mulard@pasteur.fr) and/or Marcel Hollenstein (marcel.hollenstein@pasteur.fr), who can be reached for informal inquiries about the project and the corresponding research units.