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© Research
Event

Seminar of the Structural Biology and Chemistry department: Mélanie Etheve-Quelquejeu

Scientific Fields
Diseases
Organisms
Applications
Technique
Date
15
Jan 2019
Time
14:00:00
28 Rue du Dr Roux, Paris, France
Address
Building: François Jacob Room: Auditorium François Jacob
Location
2019-01-15 14:00:00 2019-01-15 18:00:00 Europe/Paris Seminar of the Structural Biology and Chemistry department: Mélanie Etheve-Quelquejeu Seminar of the Structural Biology and Chemistry department Tuesday 15 January 2019 at 2.00 pm Salle AUDITORIUM CENTRE F. JACOB – CFJ RdC 17c Dr. Mélanie ETHEVE-QUELQUEJEU Université Paris Descartes   Modified RNAs as […] 28 Rue du Dr Roux, Paris, France Marcel Hollenstein marcel.hollenstein@pasteur.fr

About

Seminar of the Structural Biology and Chemistry department

Tuesday 15 January 2019 at 2.00 pm

Salle AUDITORIUM CENTRE F. JACOB – CFJ RdC 17c

Dr. Mélanie ETHEVE-QUELQUEJEU

Université Paris Descartes

 

Modified RNAs as Molecular Tools for Structural and Functional Studies of aminoacyl transferases and methyltransferases enzymes.

 

 Abstract. The role of RNAs in cellular processes is one of the most dynamic areas in Biology. In addition to their key functions in protein synthesis, new RNA activities are constantly discovered. To study these different biological processes, in particular, the enzymes that interact with these RNAs, we have developed synthetic methodologies to obtain stable RNAs, reactive RNAs or peptidyl-conjugates. The use of nucleoside and nucleotides chemistry, solid support synthesis, enzymatic reactions or post-functionalization methods allowed us to obtain a large variety of modified RNAs, which will be presented here. These RNA analogs were used for the study of Fem aminoacyl transferases, a tRNA-dependent enzyme that catalyze an essential step in peptidoglycan synthesis of the bacterial wall and for the study of m6A-RNA methyltransferases.

Contact : Marcel Hollenstein

Groupe à 5 ans Chimie Bioorganique des Acides Nucléiques

Marcel.hollenstein@pasteur.fr

I

Location

Building: François Jacob
Room: Auditorium François Jacob
Address: 28 Rue du Dr Roux, Paris, France