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© Research
Event

[C3BI Seminar] – Nevan Krogan: Using Systems Approaches to Understand the Mechanism of Disease

Scientific Fields
Diseases
Organisms
Applications
Technique
Date
11
Apr 2019
Time
14:00:00
25 Rue du Dr Roux, Paris, France
Address
Building: BIME Room: Auditorium Francois Jacob
Location
2019-04-11 14:00:00 2019-04-11 15:00:00 Europe/Paris [C3BI Seminar] – Nevan Krogan: Using Systems Approaches to Understand the Mechanism of Disease There is a wide gap between the generation of large-scale biological data sets and more-detailed, structural and mechanistic studies. However, recent work that explicitly combine data from systems and structural biological approaches is having […] 25 Rue du Dr Roux, Paris, France Maxime Rotival maxime.rotival@pasteur.fr

About

There is a wide gap between the generation of large-scale biological data sets and more-detailed, structural and mechanistic studies. However, recent work that explicitly combine data from systems and structural biological approaches is having a profound effect on our ability to predict how mutations and small molecules affect atomic-level mechanisms, disrupt systems-level networks and ultimately lead to changes in organismal fitness. Our group aims to create a stronger bridge between these areas primarily using three types of data: genetic interactions, protein-protein interactions and post-translational modifications.  Protein structural information helps to prioritize and functionally understand these large-scale datasets; conversely global, unbiasedly collected datasets helps inform the more mechanistic studies. Our efforts in this respect have been focused on three disease areas: cancer, infectious diseases and neuropsychiatric disorders. Our work has found remarkable similarities between these and other disease areas which are leading to novel therapeutic strategies.

Location

Building: BIME
Room: Auditorium Francois Jacob
Address: 25 Rue du Dr Roux, Paris, France