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© Research
Event

Department of Structural Biology and Chemistry seminar: Prof. Edward Egelman, Cryo-EM of Helical Protein and Nucleoprotein Polymers at Near-Atomic Resolution

Scientific Fields
Diseases
Organisms
Applications
Technique
Date
16
Apr 2019
Time
14:00:00
28 Rue du Dr Roux, Paris, France
Address
Building: François Jacob Room: Auditorium François Jacob
Location
2019-04-16 14:00:00 2019-04-16 16:00:00 Europe/Paris Department of Structural Biology and Chemistry seminar: Prof. Edward Egelman, Cryo-EM of Helical Protein and Nucleoprotein Polymers at Near-Atomic Resolution Department of Structural Biology and Chemistry SEMINAR Mardi 16 avril 2019 à 14h00 Salle AUDITORIUM CENTRE F. JACOB – CFJ RdC 17c Prof. Edward Egelman Department of Biochemistry and Molecular Genetics, University of Virginia […] 28 Rue du Dr Roux, Paris, France

About

Department of Structural Biology and Chemistry
SEMINAR

Mardi 16 avril 2019 à 14h00

Salle AUDITORIUM CENTRE F. JACOB – CFJ RdC 17c

Prof. Edward Egelman

Department of Biochemistry and Molecular Genetics, University of Virginia

 

Cryo-EM of Helical Protein and Nucleoprotein Polymers at Near-Atomic Resolution

Large amounts (sometimes the majority) of protein in eukaryotic, bacterial and archaeal cells is often found in the form of helical polymers. Viruses infecting these cells can also be helical. We have been using electron cryo-microscopy (cryo-EM) to study the structure and function of many of these polymers. Since the introduction of direct electron detectors into transmission electron microscopes about six years ago, there has been a “resolution revolution” in cryo-EM where near-atomic levels of resolution can now almost routinely be achieved for many macromolecular complexes. While some of these complexes can, in principle, be crystallized, cryo-EM has emerged as the method of choice for structural studies of such complexes as it does not require crystallization, uses far less sample, and is much faster. But for helical polymers most can never be crystallized and cryo-EM is not only the preferred method but the only method available for reaching near-atomic resolution. I will describe applications of cryo-EM to a range of systems, from viruses that infect organisms living in nearly boiling acid, to an archaeal pilus that is nearly indestructible, to “microbial nanowires” that conduct electrons. All of these studies provide not only new understanding of biology and evolution, but yield insights into novel structures that can have applications to drug delivery, biomedical engineering and nanotechnology.

Contact : Olivera Francetic

Unité Biochimie des Interactions Macromoléculaires

olivera.francetic@pasteur.fr

Location

Building: François Jacob
Room: Auditorium François Jacob
Address: 28 Rue du Dr Roux, Paris, France