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© Research

About

Progress has been achieved in curative treatments for Hepatitis C virus (HCV), however efficient cures are needed for Hepatitis B virus (HBV) and Human immunodeficiency virus (HIV). Since these pathogens have limited species tropism, infecting humans but not mice, understanding the infectious life cycle, pathological mechanisms, and testing novel drug strategies or vaccine candidates has been problematic. To overcome these limitations, we have been developing “humanized” murine models that harbor human cells, rendering mice susceptible to these infections to study immune responses and virus-host crosstalk.

Former Members

2000
2000
Name
Position
2019
2023
Anna Thaller
PhD student
2019
2022
Priyanka Fernandes
Post-doc
2015
2022
Oriane Fiquet
Assistant Engineer
2018
2021
Giulia Girelli-Zubani
Post-doc
2014
2019
Guillemette Masse-Ranson
Post-doc
2017
2019
Maud Boussand
Assistant Engineer
2011
2014
Mathilde Dusséaux
Post-doc
2009
2015
Sylvie Darche
Research Engineer

Projects

Project
Ongoing
5 Members

Modeling SARS-CoV-2 infection and immune responses in humanized mouse models

Hélène Strick-Marchand (PI)
Project
Ongoing
5 Members

Immune profiling to guide host-directed interventions to cure HBV

Hélène Strick-Marchand (PI)

The overall aim of the project is to investigate the immune responses to HBV and develop novel treatment concepts to cure chronic HBV. HBV is a major global health problem with over 257 million […]
Project
Ongoing
3 Members

Pathogen co-infection : HIV, TB, Malaria and HCV

James Di Santo (PI)

Acquired immune deficiency syndrome (AIDS), tuberculosis (TB) and malaria are the primary infectious diseases causing death world wide. TB is responsible for a third to a half of human immunodeficiency virus type 1 (HIV-1)–associated […]
Project
Ongoing
5 Members

Humanized mouse models for studying viral hepatitis

Hélène Strick-Marchand (PI)

Hepatitis B virus (HBV), hepatitis C virus (HCV) and Plasmodium falciparum are three major human hepatic pathogens, which together are responsible for more than 500 million infections worldwide and 2.5 to 4.5 million deaths […]

Fundings

Publications

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Contact

Phone:
Email: helene.strick-marchand@pasteur.fr

Address
25-28 Rue du Docteur Roux
75015, Paris
France