Timeline
Alexandre Chenal
Group Leader
30 Apr 2025
publication
Comparative analysis of the structural dynamics of diphtheria toxin and CRM197 carrier proteins used in the development of conjugate vaccines
Read more03 Mar 2025
publication
Membrane selectivity and pore formation of SprA1 and SprA2 hemolytic peptides from Staphylococcus aureus type I toxin-antitoxin systems.
Read more25 Sep 2024
publication
The effect of Ficoll 70 on thermally-induced and chemically-induced conformational transitions of an RTX protein is quantitatively accounted for by a unified excluded volume model.
Read more22 Mar 2024
publication
Genomic characterization of equine influenza A subtype H3N8 viruses by long read sequencing and functional analyses of the PB1-F2 virulence factor of A/equine/Paris/1/2018.
Read more01 Jan 2024
20 Nov 2023
publication
B2LiVe, a label-free 1D-NMR method to quantify the binding of amphitropic peptides or proteins to membrane vesicles.
Read more25 May 2023
23 Mar 2023
publication
Gallocin A, an Atypical Two-Peptide Bacteriocin with Intramolecular Disulfide Bonds Required for Activity.
Read more08 Oct 2022
publication
A Robust and Sensitive Spectrophotometric Assay for the Enzymatic Activity of Bacterial Adenylate Cyclase Toxins.
Read more08 Sep 2022
09 Aug 2022
publication
Dynamics and structural changes of calmodulin upon interaction with the antagonist calmidazolium.
Read more15 Oct 2020
publication
Development of Conformational Antibodies to Detect Bcl-xL’s Amyloid Aggregates in Metal-Induced Apoptotic Neuroblastoma Cells.
Read more18 Aug 2020
publication
Dissecting the Structural and Chemical Determinants of the “Open-to-Closed” Motion in the Mannosyltransferase PimA from Mycobacteria.
Read more02 Apr 2020
publication
Essential dynamic interdependence of FtsZ and SepF for Z-ring and septum formation in Corynebacterium glutamicum.
Read more01 Jan 2020
publication
Hydrogen/Deuterium Exchange Mass Spectrometry for the Structural Analysis of Detergent-Solubilized Membrane Proteins.
Read more01 Jan 2020
publication
Functional and structural consequences of epithelial cell invasion by Bordetella pertussis adenylate cyclase toxin.
Read more20 Dec 2019
03 Sep 2019
event
PhD defense of Alexis Voegele: Study of the translocation mechanism of the CyaA toxin from Bordetella pertussis
Read more21 Jun 2019
publication
Post-translational acylation controls the folding and functions of the CyaA RTX toxin.
Read more13 Feb 2019
publication
The Adenylate Cyclase (CyaA) Toxin from Bordetella pertussis Has No Detectable Phospholipase A (PLA) Activity In Vitro.
Read more03 Jan 2019
event
Department of Structural Biology and Chemistry Department: Paolo de Los Rios, Non-equilibrium protein folding (and unfolding) in the cell.
Read more01 Nov 2018
publication
Translocation and calmodulin-activation of the adenylate cyclase toxin (CyaA) of Bordetella pertussis.
Read more20 Jul 2018
publication
Bioengineering of Adenylate Cyclase Toxin for Antigen-Delivery and Immunotherapy
Read more14 Nov 2017
publication
Structural disorder and induced folding within two cereal, ABA stress and ripening (ASR) proteins
Read more14 Nov 2017
publication
Membrane-Active Properties of an Amphitropic Peptide from the CyaA Toxin Translocation Region
Read more28 Sep 2017
publication
Synthesis and characterization of tethered lipid assemblies for membrane protein reconstitution (Review)
Read more26 Jul 2017
publication
Exposure to Bordetella pertussis adenylate cyclase toxin affects integrin-mediated adhesion and mechanics in alveolar epithelial cells
Read more10 Feb 2017
publication
Stability, structural and functional properties of a monomeric, calcium-loaded adenylate cyclase toxin, CyaA, from Bordetella pertussis
Read more27 Jan 2017
01 Jan 2017
publication
Calmodulin fishing with a structurally disordered bait triggers CyaA catalysis.
Read more18 Aug 2016
publication
From bulk to plasmonic nanoparticle surfaces: the behavior of two potent therapeutic peptides, octreotide and pasireotide
Read more13 Jul 2016
publication
MEMHDX: an interactive tool to expedite the statistical validation and visualization of large HDX-MS datasets.
Read more09 May 2016
publication
Molecular Basis of Membrane Association by the Phosphatidylinositol Mannosyltransferase PimA Enzyme from Mycobacteria.
Read more25 Mar 2016
publication
The Tip of the Four N-Terminal α-Helices of Clostridium sordellii Lethal Toxin Contains the Interaction Site with Membrane Phosphatidylserine Facilitating Small GTPases Glucosylation
Read more20 Nov 2015
project
Biophysical characterization of the translocation process of Bordetella pertussis adenylate cyclase toxin CyaA
Read more20 Nov 2015
publication
Anchoring Sites of Fibrillogenic Peptide Hormone Somatostatin-14 on Plasmonic Nanoparticles.
Read more18 Nov 2015
16 Sep 2015
publication
Structural models of intrinsically disordered and calcium-bound folded states of a protein adapted for secretion.
Read more23 Aug 2015
17 Aug 2015
04 Aug 2015
publication
Bee venom phospholipase A2 as a membrane-binding vector for cell surface display or internalization of soluble proteins
Read more21 Jul 2015
16 Jul 2015
13 May 2015
publication
The catalytic domains of Clostridium sordellii lethal toxin and related large clostridial glucosylating toxins specifically recognize the negatively charged phospholipids phosphatidylserine and phosphatidic acid
Read more11 May 2015
31 Dec 2014
publication
Disorder-to-order transition in the CyaA toxin RTX domain: implications for toxin secretion
Read more17 Nov 2014
publication
Secondary structure reshuffling modulates glycosyltransferase function at the membrane.
Read more17 Sep 2014
publication
Calcium, acylation, and molecular confinement favor folding of Bordetella pertussis adenylate cyclase CyaA toxin into a monomeric and cytotoxic form
Read more25 Jul 2014
publication
Allosteric activation of Bordetella pertussis adenylyl cyclase by calmodulin: molecular dynamics and mutagenesis studies
Read more02 Dec 2013
publication
Bordetella pertussis adenylate cyclase toxin translocation across a tethered lipid bilayer
Read more24 Sep 2013
publication
Characterization of a membrane-active peptide from the Bordetella pertussis CyaA toxin
Read more31 Jul 2013
publication
Molecular crowding stabilizes both the intrinsically disordered calcium-free state and the folded calcium-bound state of a repeat in toxin (RTX) protein
Read more12 Jan 2012
publication
Identification of a region that assists membrane insertion and translocation of the catalytic domain of Bordetella pertussis CyaA toxin
Read more01 Jan 2012
publication
Mean net charge of intrinsically disordered proteins: experimental determination of protein valence by electrophoretic mobility measurements
Read more01 Jan 2012
publication
Estimation of intrinsically disordered protein shape and time-averaged apparent hydration in native conditions by a combination of hydrodynamic methods
Read more19 Nov 2011
15 Mar 2011
publication
Calcium-induced folding of intrinsically disordered repeat-in-toxin (RTX) motifs via changes of protein charges and oligomerization states
Read more01 Dec 2010
publication
Calcium-induced folding and stabilization of the intrinsically disordered RTX domain of the CyaA toxin
Read more22 Jan 2010
publication
Characterization of the regions involved in the calcium-induced folding of the intrinsically disordered RTX motifs from the bordetella pertussis adenylate cyclase toxin
Read more19 Jan 2010
publication
Calmodulin-induced conformational and hydrodynamic changes in the catalytic domain of Bordetella pertussis adenylate cyclase toxin
Read more24 Jul 2009
01 Jul 2009
publication
Deciphering membrane insertion of the diphtheria toxin T domain by specular neutron reflectometry and solid-state NMR spectroscopy
Read more13 May 2009
publication
Side chain resonances in static oriented proton-decoupled 15N solid-state NMR spectra of membrane proteins
Read more23 Mar 2009
publication
Cellular functions and X-ray structure of anthrolysin O, a cholesterol-dependent cytolysin secreted by Bacillus anthracis
Read more17 Nov 2008
publication
RTX calcium binding motifs are intrinsically disordered in the absence of calcium: implication for protein secretion
Read more07 Aug 2008
publication
Membrane Interaction of botulinum neurotoxin A translocation (T) domain. The belt region is a regulatory loop for membrane interaction
Read more21 Jun 2007
publication
Concerted protonation of key histidines triggers membrane interaction of the diphtheria toxin T domain
Read more15 Mar 2007
13 Feb 2007
publication
Defining the interacting regions between apomyoglobin and lipid membrane by hydrogen/deuterium exchange coupled to mass spectrometry
Read more24 Jan 2007
publication
Behavior of the N-terminal helices of the diphtheria toxin T domain during the successive steps of membrane interaction
Read more22 Jan 2007
publication
Interactions of apomyoglobin with membranes: mechanisms and effects on heme uptake
Read more20 Apr 2006
publication
Structural and functional characterization of an essential RTX subdomain of Bordetella pertussis adenylate cyclase toxin
Read more17 Jun 2005
publication
Conformational states and thermodynamics of alpha-lactalbumin bound to membranes: a case study of the effects of pH, calcium, lipid membrane curvature and charge
Read more16 Feb 2005
publication
Characterization of wild-type recombinant Bet v 1a as a candidate vaccine against birch pollen allergy
Read more30 Sep 2004
publication
Alteration of the tertiary structure of the major bee venom allergen Api m 1 by multiple mutations is concomitant with low IgE reactivity
Read more13 Aug 2004
publication
Interaction between the two subdomains of the C-terminal part of the botulinum neurotoxin A is essential for the generation of protective antibodies
Read more01 Jan 2003
publication
Anchoring cytokines to tumor cells for the preparation of anticancer vaccines without gene transfection in mice
Read more06 Sep 2002
publication
Clostridium perfringens iota toxin. Mapping of the Ia domain involved in docking with Ib and cellular internalization
Read more21 Aug 2002
publication
Membrane protein insertion regulated by bringing electrostatic and hydrophobic interactions into play. A case study with the translocation domain of diphtheria toxin
Read more01 May 2002
publication
Does fusion of domains from unrelated proteins affect their folding pathways and the structural changes involved in their function? A case study with the diphtheria toxin T domain
Read more01 Jun 2001
publication
Prolonged display or rapid internalization of the IgG-binding protein ZZ anchored to the surface of cells using the diphtheria toxin T domain
Read more01 Jan 2001
publication