Ligne de temps

26 janv. 2021

publication

Core-Modified Coelenterazine Luciferin Analogues: Synthesis and Chemiluminescence Properties.

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12 janv. 2021

publication

Measuring the subcellular compartmentalization of viral infections by protein complementation assay.

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01 janv. 2021

publication

High seroprevalence but short-lived immune response to SARS-CoV-2 infection in Paris.

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01 nov. 2020

publication

A highly sensitive bioluminescent method for measuring allergen-specific IgE in microliter samples.

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12 févr. 2020

event

Department of Structural Biology and Chemistry: Bernard Meunier, Que d’échecs dans la recherche de médicaments pour traiter la maladie d’Alzheimer !

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16 janv. 2020

publication

Bioluminescence Profiling of NanoKAZ/NanoLuc Luciferase Using a Chemical Library of Coelenterazine Analogues.

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12 nov. 2019

event

Molecular basis for evolution of the Renilla-type bioluminescence

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29 août 2019

publication

Maximizing binary interactome mapping with a minimal number of assays

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15 juil. 2019

event

Department of Structural Biology & Chemistry seminar: Dr. Bernard Meunier, Que d’échecs dans la recherche de médicaments pour traiter la maladie d’Alzheimer !

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10 avr. 2019

publication

Gram-scale synthesis of luciferins derived from coelenterazine and original insights into their bioluminescence properties.

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16 nov. 2018

publication

Unnatural α-amino ethyl esters from diethyl malonate or ethyl β-bromo-α-hydroxyiminocarboxylate

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15 nov. 2018

publication

Synthesis of unnatural α-amino esters using ethyl nitroacetate and condensation or cycloaddition reactions

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10 août 2017

publication

Synthesis of α-Amino Esters via α-Nitro or α-Oxime Esters: A Review

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12 juil. 2017

publication

Checkpoint kinase 1 inhibition sensitises transformed cells to dihydroorotate dehydrogenase inhibition

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25 sept. 2015

publication

Synthetic Routes to Coelenterazine and Other Imidazo[1,2-a]pyrazin-3-one Luciferins: Essential Tools for Bioluminescence-Based Investigations

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18 août 2015

project

Design and optimization of new bioluminescent systems better-suited to in cellulo and in vivo conditions

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28 juil. 2015

project

Alkoxypyrazoles, inhibitors of dihydroorotate dehydrogenase (DHODH)

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24 juil. 2015

project

Alkoxypyrazoles, new chemical entities

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30 juin 2015

publication

Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH)

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10 févr. 2015

publication

A study of Negishi cross-coupling reactions with benzylzinc halides to prepare original 3-ethoxypyrazoles

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06 janv. 2015

publication

Original 2-(3-alkoxy-1H-pyrazol-1-yl)pyrimidine derivatives as inhibitors of human dihydroorotate dehydrogenase (DHODH)

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20 mars 2013

publication

On dihydroorotate dehydrogenases and their inhibitors and uses

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01 janv. 2013

publication

Pyrazole-3/5-carboxylic acids from 3/5-trifluoromethyl NH-pyrazoles

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01 janv. 2013

publication

Preparations of 4-subtituted 3-carboxypyrazoles

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01 mai 2012

publication

Preparation and chemistry of 3/5-halogenopyrazoles

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01 janv. 2012

publication

3-Methoxypyrazoles from 1,1-dimethoxyethene, few original results

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01 janv. 2012

publication

Few unexpected results from a Suzuki-Miyaura reaction

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01 janv. 2011

publication

On the Knorr synthesis of 6-bromo-4-methylquinolin-2(1H)-one

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01 janv. 2011

publication

Simple preparations of 4 and 5-iodinated pyrazoles as useful building blocks

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01 oct. 2010

publication

Synthesis, biological activity, and evaluation of the mode of action of novel antitubercular benzofurobenzopyrans substituted on A ring

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23 mars 2010

publication

5-Iodo-3-ethoxypyrazoles: an entry point to new chemical entities

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15 mars 2010

publication

ATPase inhibitors of heat-shock protein 90, second season

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01 janv. 2010

publication

Synthetic accesses to 3/5-pyrazole carboxylic acids

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01 janv. 2010

publication

N-arylation of 3-alkoxypyrazoles, the case of the pyridines

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29 janv. 2009

publication

Diversity-oriented synthesis of furo[3,2-f]chromanes with antimycobacterial activity

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01 janv. 2009

publication

Carbon-4 arylation of 3-alkoxypyrazoles

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01 janv. 2009

publication

Nitrogen’s reactivity of various 3-alkoxypyrazoles

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03 août 2008

publication

A new synthetic access to furo[3,2-f]chromene analogues of an antimycobacterial

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01 janv. 2008

publication

Optimized palladium-based approaches to analogues of PK 11195

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01 janv. 2008

publication

An improved preparation of 3-alkoxypyrazoles

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19 janv. 2007

publication

Antituberculosis drugs: ten years of research

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01 janv. 2007

publication

Isoxyl activation is required for bacteriostatic activity against Mycobacterium tuberculosis

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01 janv. 2007

publication

Antimycobacterial benzofuro[3,2-f]chromenes from a 5-bromochromen-6-ol

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12 déc. 2006

publication

Synthesis and antimycobacterial evaluation of benzofurobenzopyran analogues

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01 janv. 2006

publication

A simple two steps ytterbium triflate-catalysed preparation of 2,2-dimethylchromenes from salicylaldehydes and 2-methylpropene

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01 déc. 2005

publication

Heat shock protein 90 inhibitors. A text book example of medicinal chemistry?

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01 janv. 2004

publication

Synthesis of methylenedioxy-bearing 1-aryl-3-carboxylisoquinolines using a modified Ritter reaction procedure

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01 janv. 2003

publication

Peptides with anticancer use or potential

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01 juil. 2002

publication

2-Amino-3-(3-hydroxy-1,2,5-thiadiazol-4-yl)propionic acid: resolution, absolute stereochemistry and enantiopharmacology at glutamate receptors

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Un petit guide pour l'utilisation de la recherche avancée :

Core-Modified Coelenterazine Luciferin Analogues: Synthesis and Chemiluminescence Properties.

Measuring the subcellular compartmentalization of viral infections by protein complementation assay.

High seroprevalence but short-lived immune response to SARS-CoV-2 infection in Paris.

A highly sensitive bioluminescent method for measuring allergen-specific IgE in microliter samples.

Department of Structural Biology and Chemistry: Bernard Meunier, Que d’échecs dans la recherche de médicaments pour traiter la maladie d’Alzheimer !

Bioluminescence Profiling of NanoKAZ/NanoLuc Luciferase Using a Chemical Library of Coelenterazine Analogues.

Molecular basis for evolution of the Renilla-type bioluminescence

Maximizing binary interactome mapping with a minimal number of assays

Department of Structural Biology & Chemistry seminar: Dr. Bernard Meunier, Que d’échecs dans la recherche de médicaments pour traiter la maladie d’Alzheimer !

Gram-scale synthesis of luciferins derived from coelenterazine and original insights into their bioluminescence properties.

Unnatural α-amino ethyl esters from diethyl malonate or ethyl β-bromo-α-hydroxyiminocarboxylate

Synthesis of unnatural α-amino esters using ethyl nitroacetate and condensation or cycloaddition reactions

Synthesis of α-Amino Esters via α-Nitro or α-Oxime Esters: A Review

Checkpoint kinase 1 inhibition sensitises transformed cells to dihydroorotate dehydrogenase inhibition

Synthetic Routes to Coelenterazine and Other Imidazo[1,2-a]pyrazin-3-one Luciferins: Essential Tools for Bioluminescence-Based Investigations

Design and optimization of new bioluminescent systems better-suited to in cellulo and in vivo conditions

Alkoxypyrazoles, inhibitors of dihydroorotate dehydrogenase (DHODH)

Alkoxypyrazoles, new chemical entities

Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH)

A study of Negishi cross-coupling reactions with benzylzinc halides to prepare original 3-ethoxypyrazoles

Original 2-(3-alkoxy-1H-pyrazol-1-yl)pyrimidine derivatives as inhibitors of human dihydroorotate dehydrogenase (DHODH)

On dihydroorotate dehydrogenases and their inhibitors and uses

Pyrazole-3/5-carboxylic acids from 3/5-trifluoromethyl NH-pyrazoles

Preparations of 4-subtituted 3-carboxypyrazoles

Preparation and chemistry of 3/5-halogenopyrazoles

3-Methoxypyrazoles from 1,1-dimethoxyethene, few original results

Few unexpected results from a Suzuki-Miyaura reaction

On the Knorr synthesis of 6-bromo-4-methylquinolin-2(1H)-one

Simple preparations of 4 and 5-iodinated pyrazoles as useful building blocks

Synthesis, biological activity, and evaluation of the mode of action of novel antitubercular benzofurobenzopyrans substituted on A ring

5-Iodo-3-ethoxypyrazoles: an entry point to new chemical entities

ATPase inhibitors of heat-shock protein 90, second season

Synthetic accesses to 3/5-pyrazole carboxylic acids

N-arylation of 3-alkoxypyrazoles, the case of the pyridines

Diversity-oriented synthesis of furo[3,2-f]chromanes with antimycobacterial activity

Carbon-4 arylation of 3-alkoxypyrazoles

Nitrogen’s reactivity of various 3-alkoxypyrazoles

A new synthetic access to furo[3,2-f]chromene analogues of an antimycobacterial

Optimized palladium-based approaches to analogues of PK 11195

An improved preparation of 3-alkoxypyrazoles

Antituberculosis drugs: ten years of research

Isoxyl activation is required for bacteriostatic activity against Mycobacterium tuberculosis

Antimycobacterial benzofuro[3,2-f]chromenes from a 5-bromochromen-6-ol

Synthesis and antimycobacterial evaluation of benzofurobenzopyran analogues

A simple two steps ytterbium triflate-catalysed preparation of 2,2-dimethylchromenes from salicylaldehydes and 2-methylpropene

Heat shock protein 90 inhibitors. A text book example of medicinal chemistry?

Synthesis of methylenedioxy-bearing 1-aryl-3-carboxylisoquinolines using a modified Ritter reaction procedure

Peptides with anticancer use or potential

2-Amino-3-(3-hydroxy-1,2,5-thiadiazol-4-yl)propionic acid: resolution, absolute stereochemistry and enantiopharmacology at glutamate receptors