Timeline

Yves Janin
Group Leader
12 Nov 2019
event

Molecular basis for evolution of the Renilla-type bioluminescence

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29 Aug 2019
publication

Maximizing binary interactome mapping with a minimal number of assays

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15 Jul 2019
event

Department of Structural Biology & Chemistry seminar: Dr. Bernard Meunier, Que d’échecs dans la recherche de médicaments pour traiter la maladie d’Alzheimer !

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18 Mar 2019
publication

Gram-scale synthesis of luciferins derived from coelenterazine and original insights into their bioluminescence properties

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16 Nov 2018
publication

Unnatural α-amino ethyl esters from diethyl malonate or ethyl β-bromo-α-hydroxyiminocarboxylate

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15 Nov 2018
publication

Synthesis of unnatural α-amino esters using ethyl nitroacetate and condensation or cycloaddition reactions

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10 Aug 2017
publication

Synthesis of α-Amino Esters via α-Nitro or α-Oxime Esters: A Review

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12 Jul 2017
publication

Checkpoint kinase 1 inhibition sensitises transformed cells to dihydroorotate dehydrogenase inhibition

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24 Feb 2016
team

Group : Medicinal Chemistry

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01 Jan 2016
publication

Respiratory syncytial virus infection in macaques is not suppressed by intranasal sprays of pyrimidine biosynthesis inhibitors

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01 Jan 2016
publication

Synthesis and evaluation of original bioisosteres of bacterial type IIA topoisomerases inhibitors

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25 Sep 2015
publication

Synthetic Routes to Coelenterazine and Other Imidazo[1,2-a]pyrazin-3-one Luciferins: Essential Tools for Bioluminescence-Based Investigations

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18 Aug 2015
project

Design and optimization of new bioluminescent systems better-suited to in cellulo and in vivo conditions

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18 Aug 2015
project

Finding new antimycobacterials, the dibenzofurans story

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28 Jul 2015
project

Alkoxypyrazoles, inhibitors of dihydroorotate dehydrogenase (DHODH)

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28 Jul 2015
project

ATPase inhibitors, the cases of human heat shock protein 90 and bacterial type IIA topoisomerases

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24 Jul 2015
project

Alkoxypyrazoles, new chemical entities

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30 Jun 2015
publication

Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH)

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11 May 2015
team

Chemistry and Biocatalysis

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10 Feb 2015
publication

A study of Negishi cross-coupling reactions with benzylzinc halides to prepare original 3-ethoxypyrazoles

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06 Jan 2015
publication

Original 2-(3-alkoxy-1H-pyrazol-1-yl)pyrimidine derivatives as inhibitors of human dihydroorotate dehydrogenase (DHODH)

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09 Jan 2014
publication

Bioassay-guided fractionation of extracts from Codiaeum variegatum against Entamoeba histolytica discovers compounds that modify expression of ceramide biosynthesis related genes

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01 Jan 2014
publication

Non-quinolone inhibitors of bacterial type IIA topoisomerases: a feat of bioisosterism

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20 Mar 2013
publication

On dihydroorotate dehydrogenases and their inhibitors and uses

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01 Jan 2013
publication

Pyrazole-3/5-carboxylic acids from 3/5-trifluoromethyl NH-pyrazoles

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01 Jan 2013
publication

Preparations of 4-subtituted 3-carboxypyrazoles

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01 May 2012
publication

Preparation and chemistry of 3/5-halogenopyrazoles

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01 Jan 2012
publication

3-Methoxypyrazoles from 1,1-dimethoxyethene, few original results

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01 Jan 2012
publication

Few unexpected results from a Suzuki-Miyaura reaction

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01 Jan 2011
publication

On the Knorr synthesis of 6-bromo-4-methylquinolin-2(1H)-one

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01 Jan 2011
publication

Simple preparations of 4 and 5-iodinated pyrazoles as useful building blocks

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01 Oct 2010
publication

Synthesis, biological activity, and evaluation of the mode of action of novel antitubercular benzofurobenzopyrans substituted on A ring

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23 Mar 2010
publication

5-Iodo-3-ethoxypyrazoles: an entry point to new chemical entities

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15 Mar 2010
publication

ATPase inhibitors of heat-shock protein 90, second season

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01 Jan 2010
publication

Synthetic accesses to 3/5-pyrazole carboxylic acids

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01 Jan 2010
publication

N-arylation of 3-alkoxypyrazoles, the case of the pyridines

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29 Jan 2009
publication

Diversity-oriented synthesis of furo[3,2-f]chromanes with antimycobacterial activity

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01 Jan 2009
publication

Carbon-4 arylation of 3-alkoxypyrazoles

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01 Jan 2009
publication

Nitrogen’s reactivity of various 3-alkoxypyrazoles

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03 Aug 2008
publication

A new synthetic access to furo[3,2-f]chromene analogues of an antimycobacterial

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01 Jan 2008
publication

Optimized palladium-based approaches to analogues of PK 11195

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01 Jan 2008
publication

An improved preparation of 3-alkoxypyrazoles

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19 Jan 2007
publication

Antituberculosis drugs: ten years of research

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01 Jan 2007
publication

Isoxyl activation is required for bacteriostatic activity against Mycobacterium tuberculosis

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01 Jan 2007
publication

Antimycobacterial benzofuro[3,2-f]chromenes from a 5-bromochromen-6-ol

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12 Dec 2006
publication

Synthesis and antimycobacterial evaluation of benzofurobenzopyran analogues

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01 Jan 2006
publication

A simple two steps ytterbium triflate-catalysed preparation of 2,2-dimethylchromenes from salicylaldehydes and 2-methylpropene

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01 Dec 2005
publication

Heat shock protein 90 inhibitors. A text book example of medicinal chemistry?

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01 Jan 2004
publication

Synthesis of methylenedioxy-bearing 1-aryl-3-carboxylisoquinolines using a modified Ritter reaction procedure

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01 Jan 2003
publication

Peptides with anticancer use or potential

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01 Jul 2002
publication

2-Amino-3-(3-hydroxy-1,2,5-thiadiazol-4-yl)propionic acid: resolution, absolute stereochemistry and enantiopharmacology at glutamate receptors

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