Lien vers Pubmed [PMID] – 30882838
Lien DOI – 10.1039/c9ob00459a
Org Biomol Chem 2019 04; 17(15): 3709-3713
An original gram-scale synthesis of O-acetylated forms of coelenterazine, furimazine or hydroxy-bearing analogues of luciferins is described. The comparison over two hours of their bioluminescence, using the nanoKAZ/NanoLuc luciferase, provides remarkable insights useful for the selection of a substrate adapted for a given application.