• 2024
  Sous C, Frigui W, Pawlik A, Sayes F, Ma L, Cokelaer T, Brosch R, Genomic and phenotypic characterization of Mycobacterium tuberculosis’ closest-related non-tuberculous mycobacteria., Microbiol Spectr 2024 May; (): e0412623.
• 2024
  Maure A, Lawarée E, Fiorentino F, Pawlik A, Gona S, Giraud-Gatineau A, Eldridge MJG, Danckaert A, Hardy D, Frigui W, Keck C, Gutierrez C, Neyrolles O, Aulner N, Mai A, Hamon M, Barreiro LB, Brodin P, Brosch R, Rotili D, Tailleux L, A host-directed oxadiazole compound potentiates antituberculosis treatment via zinc poisoning in human macrophages and in a mouse model of infection., PLoS Biol 2024 Apr; 22(4): e3002259.
• 2024
  Orgeur M, Sous C, Madacki J, Brosch R, Evolution and emergence of Mycobacterium tuberculosis., FEMS Microbiol Rev 2024 Mar; 48(2): .
• 2023
  Malaga W, Payros D, Meunier E, Frigui W, Sayes F, Pawlik A, Orgeur M, Berrone C, Moreau F, Mazères S, Gonzalo-Asensio J, Rengel D, Martin C, Astarie-Dequeker C, Mourey L, Brosch R, Guilhot C, Natural mutations in the sensor kinase of the PhoPR two-component regulatory system modulate virulence of ancestor-like tuberculosis bacilli., PLoS Pathog 2023 Jul; 19(7): e1011437.
• 2022
  Chitale P, Lemenze AD, Fogarty EC, Shah A, Grady C, Odom-Mabey AR, Johnson WE, Yang JH, Eren AM, Brosch R, Kumar P, Alland D, , Author Correction: A comprehensive update to the Mycobacterium tuberculosis H37Rv reference genome., Nat Commun 2022 Dec; 13(1): 7538.
• 2022
  Chitale P, Lemenze AD, Fogarty EC, Shah A, Grady C, Odom-Mabey AR, Johnson WE, Yang JH, Eren AM, Brosch R, Kumar P, Alland D, , A comprehensive update to the Mycobacterium tuberculosis H37Rv reference genome., Nat Commun 2022 Nov; 13(1): 7068.
• 2022
  Anna F, Lopez J, Moncoq F, Blanc C, Authié P, Noirat A, Fert I, Souque P, Nevo F, Pawlik A, Hardy D, Goyard S, Hudrisier D, Brosch R, Guinet F, Neyrolles O, Charneau P, Majlessi L, , A lentiviral vector expressing a dendritic cell-targeting multimer induces mucosal anti-mycobacterial CD4+ T-cell immunity., Mucosal Immunol 2022 Sep; (): .
• 2022
  Lopez J, Anna F, Authié P, Pawlik A, Ku MW, Blanc C, Souque P, Moncoq F, Noirat A, Hardy D, Sougakoff W, Brosch R, Guinet F, Charneau P, Majlessi L, , A lentiviral vector encoding fusion of light invariant chain and mycobacterial antigens induces protective CD4+ T cell immunity., Cell Rep 2022 Jul; 40(4): 111142.
• 2022
  Osman MM, Shanahan JK, Chu F, Takaki KK, Pinckert ML, Pagán AJ, Brosch R, Conrad WH, Ramakrishnan L, , The C terminus of the mycobacterium ESX-1 secretion system substrate ESAT-6 is required for phagosomal membrane damage and virulence., Proc Natl Acad Sci U S A 2022 03; 119(11): e2122161119.
• 2022
  Pérez I, Campos-Pardos E, Díaz C, Uranga S, Sayes F, Vicente F, Aguiló N, Brosch R, Martín C, Gonzalo-Asensio J, , The Mycobacterium tuberculosis PhoPR virulence system regulates expression of the universal second messenger c-di-AMP and impacts vaccine safety and efficacy., Mol Ther Nucleic Acids 2022 Mar; 27(): 1235-1248.
• 2022
  Comín J, Madacki J, Rabanaque I, Zúñiga-Antón M, Ibarz D, Cebollada A, Viñuelas J, Torres L, Sahagún J, Klopp C, Gonzalo-Asensio J, Brosch R, Iglesias MJ, Samper S, , The MtZ Strain: Molecular Characteristics and Outbreak Investigation of the Most Successful Mycobacterium tuberculosis Strain in Aragon Using Whole-Genome Sequencing., Front Cell Infect Microbiol 2022 ; 12(): 887134.
• 2021
  Allen AC, Malaga W, Gaudin C, Volle A, Moreau F, Hassan A, Astarie-Dequeker C, Peixoto A, Antoine R, Pawlik A, Frigui W, Berrone C, Brosch R, Supply P, Guilhot C, , Parallel in vivo experimental evolution reveals that increased stress resistance was key for the emergence of persistent tuberculosis bacilli., Nat Microbiol 2021 Aug; 6(8): 1082-1093.
• 2021
  Lima A, Leyva A, Rivera B, Portela MM, Gil M, Cascioferro A, Lisa MN, Wehenkel A, Bellinzoni M, Carvalho PC, Batthyány C, Alvarez MN, Brosch R, Alzari PM, Durán R, , Proteome remodeling in the Mycobacterium tuberculosis PknG knockout: Molecular evidence for the role of this kinase in cell envelope biogenesis and hypoxia response., J Proteomics 2021 Jul; 244(): 104276.
• 2021
  Jan Madacki, Mickael Orgeur, Guillem Mas Fiol, Wafa Frigui, Laurence Ma, Roland Brosch, ESX-1-Independent Horizontal Gene Transfer by Mycobacterium tuberculosis Complex Strains, mBio, 2021, 12 (3), ⟨10.1128/mBio.00965-21⟩.
• 2021
  van der Niet S, van Zon M, de Punder K, Grootemaat A, Rutten S, Moorlag SJCFM, Houben D, van der Sar AM, Bitter W, Brosch R, Hernandez Pando R, Pena MT, Peters PJ, Reits EA, Mayer-Barber KD, van der Wel NN, , IL-1R1-Dependent Signals Improve Control of Cytosolic Virulent Mycobacteria In Vivo., mSphere 2021 May; 6(3): .
• 2021
  Simeone R, Sayes F, Lawarée E, Brosch R, , Breaching the phagosome, the case of the tuberculosis agent., Cell Microbiol 2021 Apr; (): e13344.
• 2021
  Orgeur M, Frigui W, Pawlik A, Clark S, Williams A, Ates LS, Ma L, Bouchier C, Parkhill J, Brodin P, Brosch R, , Pathogenomic analyses of Mycobacterium microti, an ESX-1-deleted member of the Mycobacterium tuberculosis complex causing disease in various hosts., Microb Genom 2021 02; 7(2): .
• 2020
  Sathkumara HD, Muruganandah V, Cooper MM, Field MA, Alim MA, Brosch R, Ketheesan N, Govan B, Rush CM, Henning L, Kupz A, , Mucosal delivery of ESX-1-expressing BCG strains provides superior immunity against tuberculosis in murine type 2 diabetes., Proc. Natl. Acad. Sci. U.S.A. 2020 Aug; 117(34): 20848-20859.
• 2020
  Augenstreich J, Haanappel E, Sayes F, Simeone R, Guillet V, Mazeres S, Chalut C, Mourey L, Brosch R, Guilhot C, Astarie-Dequeker C, , Phthiocerol Dimycocerosates From Mycobacterium tuberculosis Increase the Membrane Activity of Bacterial Effectors and Host Receptors., Front Cell Infect Microbiol 2020 ; 10(): 420.
• 2020
  Giraud-Gatineau A, Coya JM, Maure A, Biton A, Thomson M, Bernard EM, Marrec J, Gutierrez MG, Larrouy-Maumus G, Brosch R, Gicquel B, Tailleux L, The antibiotic bedaquiline activates host macrophage innate immune resistance to bacterial infection, Elife 2020 May;9.
• 2020
  Pérez I, Uranga S, Sayes F, Frigui W, Samper S, Arbués A, Aguiló N, Brosch R, Martín C, Gonzalo-Asensio J, Live attenuated TB vaccines representing the three modern Mycobacterium tuberculosis lineages reveal that the Euro-American genetic background confers optimal vaccine potential, EBioMedicine 2020 Apr;55:102761.
• 2020
  Muruganandah V, Sathkumara HD, Pai S, Rush CM, Brosch R, Waardenberg AJ, Kupz A, A systematic approach to simultaneously evaluate safety, immunogenicity, and efficacy of novel tuberculosis vaccination strategies, Sci Adv 2020 03;6(10):eaaz1767.
• 2020
  Lefebvre C, Frigui W, Slama N, Lauzeral-Vizcaino F, Constant P, Lemassu A, Parish T, Eynard N, Daffé M, Brosch R, Quémard A, Discovery of a novel dehydratase of the fatty acid synthase type II critical for ketomycolic acid biosynthesis and virulence of Mycobacterium tuberculosis, Sci Rep 2020 Feb;10(1):2112.
• 2020
  Bottai D, Frigui W, Sayes F, Di Luca M, Spadoni D, Pawlik A, Zoppo M, Orgeur M, Khanna V, Hardy D, Mangenot S, Barbe V, Medigue C, Ma L, Bouchier C, Tavanti A, Larrouy-Maumus G, Brosch R, TbD1 deletion as a driver of the evolutionary success of modern epidemic Mycobacterium tuberculosis lineages, Nat Commun 2020 Feb;11(1):684.
• 2019
  Kroesen VM, Madacki J, Frigui W, Sayes F, Brosch R, Mycobacterial virulence: impact on immunogenicity and vaccine research, F1000Res 2019;8.
• 2019
  Dubois V, Pawlik A, Bories A, Le Moigne V, Sismeiro O, Legendre R, Varet H, Rodríguez-Ordóñez MDP, Gaillard JL, Coppée JY, Brosch R, Herrmann JL, Girard-Misguich F, Mycobacterium abscessus virulence traits unraveled by transcriptomic profiling in amoeba and macrophages, PLoS Pathog. 2019 Nov;15(11):e1008069.
• 2019
  Sapriel G, Brosch R, Shared pathogenomic patterns characterize a new phylotype, revealing transition towards host-adaptation long before speciation of Mycobacterium tuberculosis, Genome Biol Evol 2019; 11(8):2420–2438. doi:10.1093/gbe/evz162.
• 2019
  Vaziri F, Brosch R, ESX/Type VII Secretion Systems-An Important Way Out for Mycobacterial Proteins, Microbiol Spectr 2019 Jul;7(4).
• 2019
  Machelart A, Salzano G, Li X, Demars A, Debrie AS, Menendez-Miranda M, Pancani E, Jouny S, Hoffmann E, Deboosere N, Belhaouane I, Rouanet C, Simar S, Talahari S, Giannini V, Villemagne B, Flipo M, Brosch R, Nesslany F, Deprez B, Muraille E, Locht C, Baulard AR, Willand N, Majlessi L, Gref R, Brodin P, Intrinsic Antibacterial Activity of Nanoparticles Made of β-Cyclodextrins Potentiates Their Effect as Drug Nanocarriers Against Tuberculosis, ACS Nano 2019 Mar;.
• 2018
  Madacki J, Mas Fiol G, Brosch R, Update on the virulence factors of the obligate pathogen Mycobacterium tuberculosis and related tuberculosis-causing mycobacteria., Infect Genet Evol 2019 Aug; 72(): 67-77.
• 2018
  Girard-Misguich F, Laencina L, Dubois V, Le Moigne V, Kremer L, Maljessi L, Brosch R, Herrmann JL, [The most ancestral mycobacterial ESX-4 secretion system is essential for intracellular growth of Mycobacterium abscessus within environmental and human phagocytes], Med Sci (Paris) 2018 Oct;34(10):795-797.
• 2018
  Ates LS, Dippenaar A, Sayes F, Pawlik A, Bouchier C, Ma L, Warren RM, Sougakoff W, Majlessi L, van Heijst JWJ, Brossier F, Brosch R, Unexpected genomic and phenotypic diversity of Mycobacterium africanum Lineage 5 affects drug resistance, protein secretion and immunogenicity, Genome Biol Evol 2018 Jul;.
• 2018
  Ates LS, Sayes F, Frigui W, Ummels R, Damen MPM, Bottai D, Behr MA, van Heijst JWJ, Bitter W, Majlessi L, Brosch R, RD5-mediated lack of PE_PGRS and PPE-MPTR export in BCG vaccine strains results in strong reduction of antigenic repertoire but little impact on protection, PLoS Pathog. 2018 Jun;14(6):e1007139.
• 2018
  Sayes F, Blanc C, Ates LS, Deboosere N, Orgeur M, Le Chevalier F, Gröschel MI, Frigui W, Song OR, Lo-Man R, Brossier F, Sougakoff W, Bottai D, Brodin P, Charneau P, Brosch R, Majlessi L, Multiplexed Quantitation of Intraphagocyte Mycobacterium tuberculosis Secreted Protein Effectors, Cell Rep 2018 Apr;23(4):1072-1084.
• 2018
  Laencina L, Dubois V, Le Moigne V, Viljoen A, Majlessi L, Pritchard J, Bernut A, Piel L, Roux AL, Gaillard JL, Lombard B, Loew D, Rubin EJ, Brosch R, Kremer L, Herrmann JL, Girard-Misguich F, Identification of genes required for Mycobacterium abscessus growth in vivo with a prominent role of the ESX-4 locus, Proc. Natl. Acad. Sci. U.S.A. 2018 01;115(5):E1002-E1011.
• 2018
  Louis S. Ates, Anzaan Dippenaar, Roy Ummels, Sander R. Piersma, Aniek D. van der Woude, Kim van der Kuij, Fabien Le Chevalier, Dulce Mata-Espinosa, Jorge Barrios-Payán, Brenda Marquina-Castillo, Carolina Guapillo, Connie R. Jiménez, Arnab Pain , Edith N. G. Houben, Robin M. Warren, Roland Brosch , Rogelio Hernández-Pando and Wilbert Bitter , Mutations in ppe38 block PE_PGRS secretion and increase virulence of Mycobacterium tuberculosis, Nat Microbiol, 2018 Feb;3(2):181-188. doi: 10.1038/s41564-017-0090-6. .
• 2017
  Orgeur M, Brosch R, Evolution of virulence in the Mycobacterium tuberculosis complex, Curr. Opin. Microbiol. 2017 Dec;41:68-75.
• 2017
  Levillain F, Poquet Y, Mallet L, Mazères S, Marceau M, Brosch R, Bange FC, Supply P, Magalon A, Neyrolles O, Horizontal acquisition of a hypoxia-responsive molybdenum cofactor biosynthesis pathway contributed to Mycobacterium tuberculosis pathoadaptation, PLoS Pathog. 2017 Nov;13(11):e1006752.
• 2017
  Queval CJ, Brosch R, Simeone R, The Macrophage: A Disputed Fortress in the Battle against Mycobacterium tuberculosis, Front Microbiol 2017;8:2284.
• 2017
  Supply P, Brosch R, The Biology and Epidemiology of Mycobacterium canettii, Adv. Exp. Med. Biol. 2017;1019:27-41.
• 2017
  Kaufmann SHE, Dockrell HM, Drager N, Ho MM, McShane H, Neyrolles O, Ottenhoff THM, Patel B, Roordink D, Spertini F, Stenger S, Thole J, Verreck FAW, Williams A, , TBVAC2020: Advancing Tuberculosis Vaccines from Discovery to Clinical Development, Front Immunol 2017;8:1203.
• 2017
  Queval CJ, Song OR, Carralot JP, Saliou JM, Bongiovanni A, Deloison G, Deboosère N, Jouny S, Iantomasi R, Delorme V, Debrie AS, Park SJ, Gouveia JC, Tomavo S, Brosch R, Yoshimura A, Yeramian E, Brodin P, Mycobacterium tuberculosis Controls Phagosomal Acidification by Targeting CISH-Mediated Signaling, Cell Rep 2017 Sep;20(13):3188-3198.
• 2017
  Majlessi, L & Brosch R, Un nouveau concept pour améliorer le vaccin antituberculeux, Planet-Vie (Ressources en sciences de la vie pour les enseignants), Lundi 28 août 2017.
• 2017
  Blischak JD, Tailleux L, Myrthil M, Charlois C, Bergot E, Dinh A, Morizot G, Chény O, Platen CV, Herrmann JL, Brosch R, Barreiro LB, Gilad Y, Predicting susceptibility to tuberculosis based on gene expression profiling in dendritic cells, Sci Rep 2017 07;7(1):5702.
• 2017
  Costa-Gouveia J, Pancani E, Jouny S, Machelart A, Delorme V, Salzano G, Iantomasi R, Piveteau C, Queval CJ, Song OR, Flipo M, Deprez B, Saint-André JP, Hureaux J, Majlessi L, Willand N, Baulard A, Brodin P, Gref R, Combination therapy for tuberculosis treatment: pulmonary administration of ethionamide and booster co-loaded nanoparticles, Sci Rep 2017 Jul;7(1):5390.
• 2017
  Rieck B, Degiacomi G, Zimmermann M, Cascioferro A, Boldrin F, Lazar-Adler NR, Bottrill AR, le Chevalier F, Frigui W, Bellinzoni M, Lisa MN, Alzari PM, Nguyen L, Brosch R, Sauer U, Manganelli R, O'Hare HM, , PknG senses amino acid availability to control metabolism and virulence of Mycobacterium tuberculosis., PLoS Pathog 2017 May; 13(5): e1006399.
• 2017
  Gröschel MI, Sayes F, Shin SJ, Frigui W, Pawlik A, Orgeur M, Canetti R, Honoré N, Simeone R, van der Werf TS, Bitter W, Cho SN, Majlessi L, Brosch R,, Recombinant BCG Expressing ESX-1 of Mycobacterium marinum Combines Low Virulence with Cytosolic Immune Signaling and Improved TB Protection, Cell Reports 2017, 18, (11), 2752–2765.
• 2017
  Augenstreich J, Arbues A, Simeone R, Haanappel E, Wegener A, Sayes F, Chevalier FL, Chalut C, Malaga W, Guilhot C, Brosch R, Astarie-Dequeker C, ESX-1 and phthiocerol dimycocerosates of Mycobacterium tuberculosis act in concert to cause phagosomal rupture and host cell apoptosis, Cell. Microbiol. 2017 19:e12726.
• 2017
  Majlessi L, Sayes F, Bureau JF, Pawlik A, Michel V, Jouvion G, Huerre M, Severgnini M, Consolandi C, Peano C, Brosch R, Touati E, Leclerc C, Colonization with Helicobacter is concomitant with modified gut microbiota and drastic failure of the immune control of Mycobacterium tuberculosis, Mucosal Immunol 2017 Sep;10(5):1178-1189.
• 2017
  Conrad WH, Osman MM, Shanahan JK, Chu F, Takaki KK, Cameron J, Hopkinson-Woolley D, Brosch R, Ramakrishnan L, Mycobacterial ESX-1 secretion system mediates host cell lysis through bacterium contact-dependent gross membrane disruptions, Proc. Natl. Acad. Sci. U.S.A. 2017 Jan;.
• 2017
  Halloum I, Viljoen A, Khanna V, Craig D, Bouchier C, Brosch R, Coxon G, Kremer L, Resistance to thiacetazone derivatives active against Mycobacterium abscessus involves mutations in the MmpL5 transcriptional repressor MAB_4384, Antimicrob. Agents Chemother. 2017 Jan;.
• 2017
  van Zon M, de Punder K, van der Sar A, Brosch R, Pando RH, Grootemaat A, Tigchelaar-Gutter W, van der Wel N, Subcellular localization of M. tuberculosis in vivo and effect of the adaptive immunity, Ultrastruct Pathol 2017 Jan-Feb;41(1):133.
• 2016
  Ates, L.S. & Brosch, R., Discovery of the type VII ESX-1 secretion needle ?, Mol. Microbiol. 103(1):7-12..
• 2016
  Stinear T.P. & Brosch R., Leprosy in red squirrels, Science 2016 ;354 (6313): 702-703.
• 2016
  Roux AL, Viljoen A, Bah A, Simeone R, Bernut A, Laencina L, Deramaudt T, Rottman M, Gaillard JL, Majlessi L, Brosch R, Girard-Misguich F, Vergne I, de Chastellier C, Kremer L, Herrmann JL, The distinct fate of smooth and rough Mycobacterium abscessus variants inside macrophages, Open Biol 2016 Nov;6(11).
• 2016
  Boritsch EC, Brosch R, Evolution of Mycobacterium tuberculosis: New Insights into Pathogenicity and Drug Resistance, Microbiol Spectr 2016 Oct;4(5).
• 2016
  Gröschel MI, Sayes F, Simeone R, Majlessi L, Brosch R, ESX secretion systems: mycobacterial evolution to counter host immunity, Nat. Rev. Microbiol. 2016, 14(11):677-691..
• 2016
  Boritsch EC, Khanna V, Pawlik A, Honoré N, Navas VH, Ma L, Bouchier C, Seemann T, Supply P, Stinear TP, Brosch R, Key experimental evidence of chromosomal DNA transfer among selected tuberculosis-causing mycobacteria, Proc. Natl. Acad. Sci. U.S.A. 2016 Aug;.
• 2016
  Sayes F, Pawlik A, Frigui W, Gröschel MI, Crommelynck S, Fayolle C, Cia F, Bancroft GJ, Bottai D, Leclerc C, Brosch R, Majlessi L., CD4+ T Cells Recognizing PE/PPE Antigens Directly or via Cross Reactivity Are Protective against Pulmonary Mycobacterium tuberculosis Infection, PLoS Pathog. 2016 Jul 28;12(7):e1005770. doi: 10.1371/journal.ppat.1005770..
• 2016
  Nebenzahl-Guimaraes, H., Yimer, S.A., Holm-Hansen, C., de Beer, J., Brosch, R., van Soolingen, D., Genomic characterization of Mycobacterium tuberculosis lineage 7 and a proposed name: ‘Aethiops vetus’, doi: 10.1099/mgen.0.000063.
• 2016
  Simeone R, Majlessi L, Enninga J, Brosch R, Perspectives on mycobacterial vacuole-to-cytosol translocation: the importance of cytosolic access, Cell. Microbiol. 2016 May;.
• 2016
  Dupont C, Viljoen A, Dubar F, Blaise M, Bernut A, Pawlik A, Bouchier C, Brosch R, Guérardel Y, Lelièvre J, Ballell L, Herrmann JL, Biot C, Kremer L, A new piperidinol derivative targeting mycolic acid transport in Mycobacterium abscessus, Mol. Microbiol. , 101, (3 ) 2016 .
• 2016
  Singh VK, Berry L, Bernut A, Singh S, Carrère-Kremer S, Viljoen A, Alibaud L, Majlessi L, Brosch R, Chaturvedi V, Geurtsen J, Drancourt M, Kremer L, A unique PE_PGRS protein inhibiting host cell cytosolic defenses and sustaining full virulence of Mycobacterium marinum in multiple hosts, Cell. Microbiol. 2016 Apr;.
• 2016
  Kupz A, Zedler U, Stäber M, Perdomo C, Dorhoi A, Brosch R, Kaufmann SH, ESAT-6-dependent cytosolic pattern recognition drives noncognate tuberculosis control in vivo, The Journal of Clinical Investigation.
• 2016
  Sapriel G, Konjek J, Orgeur M, Bouri L, Frézal L, Roux AL, Dumas E, Brosch R, Bouchier C, Brisse S, Vandenbogaert M, Thiberge JM, Caro V, Ngeow YF, Tan JL, Herrmann JL, Gaillard JL, Heym B, Wirth T, Genome-wide mosaicism within Mycobacterium abscessus: evolutionary and epidemiological implications., BMC Genomics 2016 Feb; 17(): 118.
• 2016
  Bottai D, Brosch R, The BCG Strain Pool: Diversity Matters, Mol. Ther. 2016 Feb;24(2):201-3.
• 2016
  Eva C. Boritsch, Wafa Frigui, Alessandro Cascioferro, Wladimir Malaga, Gilles Etienne, Françoise Laval, Alexandre Pawlik, Fabien Le Chevalier, Mickael Orgeur, Laurence Ma, Christiane Bouchier, Timothy P. Stinear, Philip Supply, Laleh Majlessi, Mamadou Daffé, Christophe Guilhot & Roland Brosch, pks5-recombination-mediated surface remodelling in Mycobacterium tuberculosis emergence, Nature Microbiol. 1, 15019 (2016).
• 2016
  Dumas E, Boritsch EC, Vandenbogaert M, Rodríguez de la Vega RC, Thiberge JM, Caro V, Gaillard JL, Heym B, Girard-Misguich F, Brosch R, Sapriel G, Mycobacterial pan-genome analysis suggests important role of plasmids in the radiation of type VII secretion systems, Genome Biology and Evolution.
• 2016
  Bottai D, Gröschel MI, Brosch R, Type VII Secretion Systems in Gram-Positive Bacteria, Curr. Top. Microbiol. Immunol. 2016 Jan;.
• 2015
  Bernut A, Viljoen A, Dupont C, Sapriel G, Blaise M, Bouchier C, Brosch R, de Chastellier C, Herrmann JL, Kremer L, Insights into the smooth-to-rough transitioning in Mycobacterium bolletii unravels a functional Tyr residue conserved in all mycobacterial MmpL family members, Mol. Microbiol. 2016 Mar;99(5):866-83.
• 2015
  Etna MP, Giacomini E, Pardini M, Severa M, Bottai D, Cruciani M, Rizzo F, Calogero R, Brosch R, Coccia EM, Impact of Mycobacterium tuberculosis RD1-locus on human primary dendritic cell immune functions, Sci Rep 2015 Nov;5:17078.
• 2015
  Le Chevalier F, Cascioferro A, Frigui W, Pawlik A, Boritsch EC, Bottai D, Majlessi L, Herrmann JL, Brosch R, Revisiting the role of phospholipases C in virulence and the lifecycle of Mycobacterium tuberculosis, Sci Rep 2015;5:16918.
• 2015
  Slama N, Jamet S, Frigui W, Pawlik A, Bottai D, Laval F, Constant P, Lemassu A, Cam K, Daffé M, Brosch R, Eynard N, Quémard A, The changes in mycolic acid structures caused by hadC mutation have a dramatic effect on the virulence of Mycobacterium tuberculosis, Mol. Microbiol. 2015 Nov;.
• 2015
  Abdallah AM, Hill-Cawthorne GA, Otto TD, Coll F, Guerra-Assunção JA, Gao G, Naeem R, Ansari H, Malas TB, Adroub SA, Verboom T, Ummels R, Zhang H, Panigrahi AK, McNerney R, Brosch R, Clark TG, Behr MA, Bitter W, Pain A, Genomic expression catalogue of a global collection of BCG vaccine strains show evidence for highly diverged metabolic and cell-wall adaptations, Sci Rep 2015;5:15443.
• 2015
  Majlessi L, Brosch R, Mycobacterium tuberculosis Meets the Cytosol: The Role of cGAS in Anti-mycobacterial Immunity, Cell Host Microbe 2015 Jun;17(6):733-5.
• 2015
  Bottai D, Frigui W, Clark S, Rayner E, Zelmer A, Andreu N, de Jonge MI, Bancroft GJ, Williams A, Brodin P, Brosch R, Increased protective efficacy of recombinant BCG strains expressing virulence-neutral proteins of the ESX-1 secretion system, Vaccine 2015 May;33(23):2710-8.
• 2015
  Brosch R, Guilhot C, [Bovine tubercle bacilli: evolution associated with loss of transmission capacity in humans], Med Sci (Paris) 2015 Feb;31(2):123-6.
• 2015
  Majlessi L, Prados-Rosales R, Casadevall A, Brosch R, Release of mycobacterial antigens, Immunol. Rev. 2015 Mar;264(1):25-45.
• 2015
  Wang J, McIntosh F, Radomski N, Dewar K, Simeone R, Enninga J, Brosch R, Rocha EP, Veyrier FJ, Behr MA, Insights on the emergence of Mycobacterium tuberculosis from the analysis of Mycobacterium kansasii, Genome Biol Evol 2015 Mar;7(3):856-70.
• 2015
  Simeone R, Bottai D, Frigui W, Majlessi L, Brosch R, ESX/type VII secretion systems of mycobacteria: Insights into evolution, pathogenicity and protection, Tuberculosis (Edinb) 2015 Feb;.
• 2015
  Simeone R, Sayes F, Song O, Gröschel MI, Brodin P, Brosch R, Majlessi L, Cytosolic access of Mycobacterium tuberculosis: critical impact of phagosomal acidification control and demonstration of occurrence in vivo, PLoS Pathog. 2015 Feb;11(2):e1004650.
• 2014
  Bakala N'Goma JC, Le Moigne V, Soismier N, Laencina L, Le Chevalier F, Roux AL, Poncin I, Serveau-Avesque C, Rottman M, Gaillard JL, Etienne G, Brosch R, Herrmann JL, Canaan S, Girard-Misguich F, Mycobacterium abscessus phospholipase C expression is induced during coculture within amoebae and enhances M. abscessus virulence in mice, Infect. Immun. 2015 Feb;83(2):780-91.
• 2014
  Boritsch EC, Supply P, Honoré N, Seemann T, Stinear TP, Brosch R, A glimpse into the past and predictions for the future: the molecular evolution of the tuberculosis agent, Mol. Microbiol. 2014 Sep;93(5):835-52.
• 2014
  Gonzalo-Asensio J, Malaga W, Pawlik A, Astarie-Dequeker C, Passemar C, Moreau F, Laval F, Daffé M, Martin C, Brosch R, Guilhot C, Evolutionary history of tuberculosis shaped by conserved mutations in the PhoPR virulence regulator, Proc. Natl. Acad. Sci. U.S.A. 2014 Aug;111(31):11491-6.
• 2014
  Solans L, Aguiló N, Samper S, Pawlik A, Frigui W, Martín C, Brosch R, Gonzalo-Asensio J, A specific polymorphism in Mycobacterium tuberculosis H37Rv causes differential ESAT-6 expression and identifies WhiB6 as a novel ESX-1 component, Infect. Immun. 2014 Aug;82(8):3446-56.
• 2014
  Gouzy A, Larrouy-Maumus G, Bottai D, Levillain F, Dumas A, Wallach JB, Caire-Brandli I, de Chastellier C, Wu TD, Poincloux R, Brosch R, Guerquin-Kern JL, Schnappinger D, Sório de Carvalho LP, Poquet Y, Neyrolles O, Mycobacterium tuberculosis exploits asparagine to assimilate nitrogen and resist acid stress during infection, PLoS Pathog. 2014 Feb;10(2):e1003928.
• 2014
  Bottai D, Stinear TP, Supply P, Brosch R, Mycobacterial Pathogenomics and Evolution, Microbiol Spectr 2014 Feb;2(1):MGM2-0025-2013.
• 2014
  Le Chevalier F, Cascioferro A, Majlessi L, Herrmann JL, Brosch R, Mycobacterium tuberculosis evolutionary pathogenesis and its putative impact on drug development, Future Microbiol 2014;9(8):969-85.
• 2014
  Bottai D, Serafini A, Cascioferro A, Brosch R, Manganelli R, Targeting type VII/ESX secretion systems for development of novel antimycobacterial drugs, Curr. Pharm. Des. 2014;20(27):4346-56.
• 2013
  Pawlik A, Garnier G, Orgeur M, Tong P, Lohan A, Le Chevalier F, Sapriel G, Roux AL, Conlon K, Honoré N, Dillies MA, Ma L, Bouchier C, Coppée JY, Gaillard JL, Gordon SV, Loftus B, Brosch R, Herrmann JL, Identification and characterization of the genetic changes responsible for the characteristic smooth-to-rough morphotype alterations of clinically persistent Mycobacterium abscessus, Mol. Microbiol. 2013 Nov;90(3):612-29.
• 2013
  Aguilo JI, Alonso H, Uranga S, Marinova D, Arbués A, de Martino A, Anel A, Monzon M, Badiola J, Pardo J, Brosch R, Martin C, ESX-1-induced apoptosis is involved in cell-to-cell spread of Mycobacterium tuberculosis, Cell. Microbiol. 2013 Dec;15(12):1994-2005.
• 2013
  Keller C, Mellouk N, Danckaert A, Simeone R, Brosch R, Enninga J, Bobard A, Single cell measurements of vacuolar rupture caused by intracellular pathogens, J Vis Exp 2013 Jun;(76):e50116.
• 2013
  van Ingen J, Brosch R, van Soolingen D, Characterization of Mycobacterium orygis, Emerging Infect. Dis. 2013 Mar;19(3):521-2.
• 2013
  Brennan PJ, Brosch R, Birren B, Sobral B, TBCAP; tuberculosis annotation project, Tuberculosis (Edinb) 2013 Jan;93(1):1-5.
• 2013
  Supply P, Marceau M, Mangenot S, Roche D, Rouanet C, Khanna V, Majlessi L, Criscuolo A, Tap J, Pawlik A, Fiette L, Orgeur M, Fabre M, Parmentier C, Frigui W, Simeone R, Boritsch EC, Debrie AS, Willery E, Walker D, Quail MA, Ma L, Bouchier C, Salvignol G, Sayes F, Cascioferro A, Seemann T, Barbe V, Locht C, Gutierrez MC, Leclerc C, Bentley SD, Stinear TP, Brisse S, Médigue C, Parkhill J, Cruveiller S, Brosch R, Genomic analysis of smooth tubercle bacilli provides insights into ancestry and pathoadaptation of Mycobacterium tuberculosis, Nat. Genet. 2013 Feb;45(2):172-9.
• 2012
  Di Luca M, Bottai D, Batoni G, Orgeur M, Aulicino A, Counoupas C, Campa M, Brosch R, Esin S, The ESX-5 associated eccB-EccC locus is essential for Mycobacterium tuberculosis viability, PLoS ONE 2012;7(12):e52059.
• 2012
  Romagnoli A, Etna MP, Giacomini E, Pardini M, Remoli ME, Corazzari M, Falasca L, Goletti D, Gafa V, Simeone R, Delogu G, Piacentini M, Brosch R, Fimia GM, Coccia EM, ESX-1 dependent impairment of autophagic flux by Mycobacterium tuberculosis in human dendritic cells, Autophagy 2012 Sep;8(9):1357-70.
• 2012
  Banu S, Mahmud AM, Rahman MT, Hossain A, Uddin MK, Ahmed T, Khatun R, Akhanda W, Brosch R, Multidrug-resistant tuberculosis in admitted patients at a tertiary referral hospital of Bangladesh, PLoS ONE 2012;7(7):e40545.
• 2012
  Houben D, Demangel C, van Ingen J, Perez J, Baldeón L, Abdallah AM, Caleechurn L, Bottai D, van Zon M, de Punder K, van der Laan T, Kant A, Bossers-de Vries R, Willemsen P, Bitter W, van Soolingen D, Brosch R, van der Wel N, Peters PJ, ESX-1-mediated translocation to the cytosol controls virulence of mycobacteria, Cell. Microbiol. 2012 Aug;14(8):1287-98.
• 2012
  Sayes F, Sun L, Di Luca M, Simeone R, Degaiffier N, Fiette L, Esin S, Brosch R, Bottai D, Leclerc C, Majlessi L, Strong immunogenicity and cross-reactivity of Mycobacterium tuberculosis ESX-5 type VII secretion: encoded PE-PPE proteins predicts vaccine potential, Cell Host Microbe 2012 Apr;11(4):352-63.
• 2012
  van Ingen J, Rahim Z, Mulder A, Boeree MJ, Simeone R, Brosch R, van Soolingen D, Characterization of Mycobacterium orygis as M. tuberculosis complex subspecies, Emerging Infect. Dis. 2012 Apr;18(4):653-5.
• 2012
  Bottai D, Di Luca M, Majlessi L, Frigui W, Simeone R, Sayes F, Bitter W, Brennan MJ, Leclerc C, Batoni G, Campa M, Brosch R, Esin S, Disruption of the ESX-5 system of Mycobacterium tuberculosis causes loss of PPE protein secretion, reduction of cell wall integrity and strong attenuation, Mol. Microbiol. 2012 Mar;83(6):1195-209.
• 2012
  Simeone R, Bobard A, Lippmann J, Bitter W, Majlessi L, Brosch R, Enninga J, Phagosomal rupture by Mycobacterium tuberculosis results in toxicity and host cell death, PLoS Pathog. 2012 Feb;8(2):e1002507.
• 2012
  Banu S, Uddin MK, Islam MR, Zaman K, Ahmed T, Talukder AH, Rahman MT, Rahim Z, Akter N, Khatun R, Brosch R, Endtz HP, Molecular epidemiology of tuberculosis in rural Matlab, Bangladesh, Int. J. Tuberc. Lung Dis. 2012;16(3):319-26.
• 2011
  Dorhoi A, Nouailles G, Jörg S, Hagens K, Heinemann E, Pradl L, Oberbeck-Müller D, Duque-Correa MA, Reece ST, Ruland J, Brosch R, Tschopp J, Gross O, Kaufmann SH, Activation of the NLRP3 inflammasome by Mycobacterium tuberculosis is uncoupled from susceptibility to active tuberculosis, Eur. J. Immunol. 2012 Feb;42(2):374-84.
• 2011
  Bottai D, Majlessi L, Simeone R, Frigui W, Laurent C, Lenormand P, Chen J, Rosenkrands I, Huerre M, Leclerc C, Cole ST, Brosch R, ESAT-6 secretion-independent impact of ESX-1 genes espF and espG1 on virulence of Mycobacterium tuberculosis, J. Infect. Dis. 2011 Apr;203(8):1155-64.
• 2011
  Alonso H, Aguilo JI, Samper S, Caminero JA, Campos-Herrero MI, Gicquel B, Brosch R, Martín C, Otal I, Deciphering the role of IS6110 in a highly transmissible Mycobacterium tuberculosis Beijing strain, GC1237, Tuberculosis (Edinb) 2011 Mar;91(2):117-26.
• 2011
  Roux AL, Ray A, Pawlik A, Medjahed H, Etienne G, Rottman M, Catherinot E, Coppée JY, Chaoui K, Monsarrat B, Toubert A, Daffé M, Puzo G, Gaillard JL, Brosch R, Dulphy N, Nigou J, Herrmann JL, Overexpression of proinflammatory TLR-2-signalling lipoproteins in hypervirulent mycobacterial variants, Cell. Microbiol. 2011 May;13(5):692-704.
• 2010
  Termentzi A, Khouri I, Gaslonde T, Prado S, Saint-Joanis B, Bardou F, Amanatiadou EP, Vizirianakis IS, Kordulakova J, Jackson M, Brosch R, Janin YL, Daffé M, Tillequin F, Michel S, Synthesis, biological activity, and evaluation of the mode of action of novel antitubercular benzofurobenzopyrans substituted on A ring, Eur J Med Chem 2010 Dec;45(12):5833-47.
• 2010
  Brodin P, Poquet Y, Levillain F, Peguillet I, Larrouy-Maumus G, Gilleron M, Ewann F, Christophe T, Fenistein D, Jang J, Jang MS, Park SJ, Rauzier J, Carralot JP, Shrimpton R, Genovesio A, Gonzalo-Asensio JA, Puzo G, Martin C, Brosch R, Stewart GR, Gicquel B, Neyrolles O, High content phenotypic cell-based visual screen identifies Mycobacterium tuberculosis acyltrehalose-containing glycolipids involved in phagosome remodeling, PLoS Pathog. 2010;6(9):e1001100.
• 2010
  Fears R, Kaufmann S, Ter Meulen V, Zumla A, , Drug-resistant tuberculosis in the European Union: opportunities and challenges for control, Tuberculosis (Edinb) 2010 May;90(3):182-7.
• 2009
  Christophe T, Jackson M, Jeon HK, Fenistein D, Contreras-Dominguez M, Kim J, Genovesio A, Carralot JP, Ewann F, Kim EH, Lee SY, Kang S, Seo MJ, Park EJ, Skovierová H, Pham H, Riccardi G, Nam JY, Marsollier L, Kempf M, Joly-Guillou ML, Oh T, Shin WK, No Z, Nehrbass U, Brosch R, Cole ST, Brodin P, High content screening identifies decaprenyl-phosphoribose 2′ epimerase as a target for intracellular antimycobacterial inhibitors, PLoS Pathog. 2009 Oct;5(10):e1000645.
• 2009
  Bitter W, Houben EN, Bottai D, Brodin P, Brown EJ, Cox JS, Derbyshire K, Fortune SM, Gao LY, Liu J, Gey van Pittius NC, Pym AS, Rubin EJ, Sherman DR, Cole ST, Brosch R, Systematic genetic nomenclature for type VII secretion systems, PLoS Pathog. 2009 Oct;5(10):e1000507.
• 2009
  Gutierrez MC, Supply P, Brosch R, Pathogenomics of mycobacteria, Genome Dyn 2009;6:198-210.
• 2009
  Saint-Joanis B, Brosch R, [A promising new class of antituberculous molecules], Med Sci (Paris) 2009 Aug-Sep;25(8-9):663-5.
• 2009
  Bottai D, Brosch R, Mycobacterial PE, PPE and ESX clusters: novel insights into the secretion of these most unusual protein families, Mol. Microbiol. 2009 Aug;73(3):325-8.
• 2009
  Ripoll F, Pasek S, Schenowitz C, Dossat C, Barbe V, Rottman M, Macheras E, Heym B, Herrmann JL, Daffé M, Brosch R, Risler JL, Gaillard JL, Non mycobacterial virulence genes in the genome of the emerging pathogen Mycobacterium abscessus, PLoS ONE 2009;4(6):e5660.
• 2009
  Smith NH, Hewinson RG, Kremer K, Brosch R, Gordon SV, Myths and misconceptions: the origin and evolution of Mycobacterium tuberculosis, Nat. Rev. Microbiol. 2009 Jul;7(7):537-44.
• 2009
  Gordon SV, Bottai D, Simeone R, Stinear TP, Brosch R, Pathogenicity in the tubercle bacillus: molecular and evolutionary determinants, Bioessays 2009 Apr;31(4):378-88.
• 2009
  Makarov V, Manina G, Mikusova K, Möllmann U, Ryabova O, Saint-Joanis B, Dhar N, Pasca MR, Buroni S, Lucarelli AP, Milano A, De Rossi E, Belanova M, Bobovska A, Dianiskova P, Kordulakova J, Sala C, Fullam E, Schneider P, McKinney JD, Brodin P, Christophe T, Waddell S, Butcher P, Albrethsen J, Rosenkrands I, Brosch R, Nandi V, Bharath S, Gaonkar S, Shandil RK, Balasubramanian V, Balganesh T, Tyagi S, Grosset J, Riccardi G, Cole ST, Benzothiazinones kill Mycobacterium tuberculosis by blocking arabinan synthesis, Science 2009 May;324(5928):801-4.
• 2009
  Simeone R, Bottai D, Brosch R, ESX/type VII secretion systems and their role in host-pathogen interaction, Curr. Opin. Microbiol. 2009 Feb;12(1):4-10.
• 2008
  Wheeler PR, Brosch R, Coldham NG, Inwald JK, Hewinson RG, Gordon SV, Functional analysis of a clonal deletion in an epidemic strain of Mycobacterium bovis reveals a role in lipid metabolism, Microbiology (Reading, Engl.) 2008 Dec;154(Pt 12):3731-42.
• 2008
  Stinear TP, Seemann T, Harrison PF, Jenkin GA, Davies JK, Johnson PD, Abdellah Z, Arrowsmith C, Chillingworth T, Churcher C, Clarke K, Cronin A, Davis P, Goodhead I, Holroyd N, Jagels K, Lord A, Moule S, Mungall K, Norbertczak H, Quail MA, Rabbinowitsch E, Walker D, White B, Whitehead S, Small PL, Brosch R, Ramakrishnan L, Fischbach MA, Parkhill J, Cole ST, Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis, Genome Res. 2008 May;18(5):729-41.
• 2008
  Frigui W, Bottai D, Majlessi L, Monot M, Josselin E, Brodin P, Garnier T, Gicquel B, Martin C, Leclerc C, Cole ST, Brosch R, Control of M. tuberculosis ESAT-6 secretion and specific T cell recognition by PhoP, PLoS Pathog. 2008 Feb;4(2):e33.
• 2007
  de Jonge MI, Pehau-Arnaudet G, Fretz MM, Romain F, Bottai D, Brodin P, Honoré N, Marchal G, Jiskoot W, England P, Cole ST, Brosch R, ESAT-6 from Mycobacterium tuberculosis dissociates from its putative chaperone CFP-10 under acidic conditions and exhibits membrane-lysing activity, J. Bacteriol. 2007 Aug;189(16):6028-34.
• 2007
  Brosch R, Vincent V, Cutting-edge science and the future of tuberculosis control, Bull. World Health Organ. 2007 May;85(5):410-2.
• 2007
  Brosch R, Gordon SV, Garnier T, Eiglmeier K, Frigui W, Valenti P, Dos Santos S, Duthoy S, Lacroix C, Garcia-Pelayo C, Inwald JK, Golby P, Garcia JN, Hewinson RG, Behr MA, Quail MA, Churcher C, Barrell BG, Parkhill J, Cole ST, Genome plasticity of BCG and impact on vaccine efficacy, Proc. Natl. Acad. Sci. U.S.A. 2007 Mar;104(13):5596-601.
• 2006
  Brisse S, Supply P, Brosch R, Vincent V, Gutierrez MC, “A re-evaluation of M. prototuberculosis”: continuing the debate, PLoS Pathog. 2006 Sep;2(9):e95.
• 2006
  Rosas-Magallanes V, Deschavanne P, Quintana-Murci L, Brosch R, Gicquel B, Neyrolles O, Horizontal transfer of a virulence operon to the ancestor of Mycobacterium tuberculosis, Mol. Biol. Evol. 2006 Jun;23(6):1129-35.
• 2006
  Brodin P, Majlessi L, Marsollier L, de Jonge MI, Bottai D, Demangel C, Hinds J, Neyrolles O, Butcher PD, Leclerc C, Cole ST, Brosch R, Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence, Infect. Immun. 2006 Jan;74(1):88-98.
• 2005
  Gutierrez MC, Brisse S, Brosch R, Fabre M, Omaïs B, Marmiesse M, Supply P, Vincent V, Ancient origin and gene mosaicism of the progenitor of Mycobacterium tuberculosis, PLoS Pathog. 2005 Sep;1(1):e5.
• 2005
  de Jonge MI, Brosch R, Brodin P, Demangel C, Cole ST, Tuberculosis: from genome to vaccine, Expert Rev Vaccines 2005 Aug;4(4):541-51.
• 2005
  Coutanceau E, Marsollier L, Brosch R, Perret E, Goossens P, Tanguy M, Cole ST, Small PL, Demangel C, Modulation of the host immune response by a transient intracellular stage of Mycobacterium ulcerans: the contribution of endogenous mycolactone toxin, Cell. Microbiol. 2005 Aug;7(8):1187-96.
• 2005
  Brodin P, de Jonge MI, Majlessi L, Leclerc C, Nilges M, Cole ST, Brosch R, Functional analysis of early secreted antigenic target-6, the dominant T-cell antigen of Mycobacterium tuberculosis, reveals key residues involved in secretion, complex formation, virulence, and immunogenicity, J. Biol. Chem. 2005 Oct;280(40):33953-9.
• 2005
  Guimarães BG, Souchon H, Honoré N, Saint-Joanis B, Brosch R, Shepard W, Cole ST, Alzari PM, Structure and mechanism of the alkyl hydroperoxidase AhpC, a key element of the Mycobacterium tuberculosis defense system against oxidative stress, J. Biol. Chem. 2005 Jul;280(27):25735-42.
• 2005
  Majlessi L, Brodin P, Brosch R, Rojas MJ, Khun H, Huerre M, Cole ST, Leclerc C, Influence of ESAT-6 secretion system 1 (RD1) of Mycobacterium tuberculosis on the interaction between mycobacteria and the host immune system, J. Immunol. 2005 Mar;174(6):3570-9.
• 2005
  Stinear TP, Hong H, Frigui W, Pryor MJ, Brosch R, Garnier T, Leadlay PF, Cole ST, Common evolutionary origin for the unstable virulence plasmid pMUM found in geographically diverse strains of Mycobacterium ulcerans, J. Bacteriol. 2005 Mar;187(5):1668-76.
• 2004
  Brodin P, Rosenkrands I, Andersen P, Cole ST, Brosch R, ESAT-6 proteins: protective antigens and virulence factors?, Trends Microbiol. 2004 Nov;12(11):500-8.
• 2004
  Brodin P, Majlessi L, Brosch R, Smith D, Bancroft G, Clark S, Williams A, Leclerc C, Cole ST, Enhanced protection against tuberculosis by vaccination with recombinant Mycobacterium microti vaccine that induces T cell immunity against region of difference 1 antigens, J. Infect. Dis. 2004 Jul;190(1):115-22.
• 2004
  Demangel C, Brodin P, Cockle PJ, Brosch R, Majlessi L, Leclerc C, Cole ST, Cell envelope protein PPE68 contributes to Mycobacterium tuberculosis RD1 immunogenicity independently of a 10-kilodalton culture filtrate protein and ESAT-6, Infect. Immun. 2004 Apr;72(4):2170-6.
• 2004
  Marmiesse M, Brodin P, Buchrieser C, Gutierrez C, Simoes N, Vincent V, Glaser P, Cole ST, Brosch R, Macro-array and bioinformatic analyses reveal mycobacterial ‘core’ genes, variation in the ESAT-6 gene family and new phylogenetic markers for the Mycobacterium tuberculosis complex, Microbiology (Reading, Engl.) 2004 Feb;150(Pt 2):483-96.
• 2004
  Banu S, Gordon SV, Palmer S, Islam MR, Ahmed S, Alam KM, Cole ST, Brosch R, Genotypic analysis of Mycobacterium tuberculosis in Bangladesh and prevalence of the Beijing strain, J. Clin. Microbiol. 2004 Feb;42(2):674-82.
• 2004
  Stinear TP, Mve-Obiang A, Small PL, Frigui W, Pryor MJ, Brosch R, Jenkin GA, Johnson PD, Davies JK, Lee RE, Adusumilli S, Garnier T, Haydock SF, Leadlay PF, Cole ST, Giant plasmid-encoded polyketide synthases produce the macrolide toxin of Mycobacterium ulcerans, Proc. Natl. Acad. Sci. U.S.A. 2004 Feb;101(5):1345-9.
• 2004
  Demangel C, Brosch R, Marmiesse M, Cole ST, [Use of the mycobacteria genome to develop new vaccines and therapeutic targets], Med Trop (Mars) 2004;64(3):221-3.
• 2003
  Pym AS, Brodin P, Majlessi L, Brosch R, Demangel C, Williams A, Griffiths KE, Marchal G, Leclerc C, Cole ST, Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis, Nat. Med. 2003 May;9(5):533-9.
• 2003
  Sola C, Rastogi N, Gutierrez MC, Vincent V, Brosch R, Parsons L, Is Mycobacterium africanum subtype II (Uganda I and Uganda II) a genetically well-defined subspecies of the Mycobacterium tuberculosis complex?, J. Clin. Microbiol. 2003 Mar;41(3):1345-6; author reply 1346-8.
• 2002
  Pym AS, Brodin P, Brosch R, Huerre M, Cole ST, Loss of RD1 contributed to the attenuation of the live tuberculosis vaccines Mycobacterium bovis BCG and Mycobacterium microti, Mol. Microbiol. 2002 Nov;46(3):709-17.
• 2002
  Brodin P, Eiglmeier K, Marmiesse M, Billault A, Garnier T, Niemann S, Cole ST, Brosch R, Bacterial artificial chromosome-based comparative genomic analysis identifies Mycobacterium microti as a natural ESAT-6 deletion mutant, Infect. Immun. 2002 Oct;70(10):5568-78.
• 2002
  Parsons LM, Brosch R, Cole ST, Somoskövi A, Loder A, Bretzel G, Van Soolingen D, Hale YM, Salfinger M, Rapid and simple approach for identification of Mycobacterium tuberculosis complex isolates by PCR-based genomic deletion analysis, J. Clin. Microbiol. 2002 Jul;40(7):2339-45.
• 2002
  Brosch R, Gordon SV, Marmiesse M, Brodin P, Buchrieser C, Eiglmeier K, Garnier T, Gutierrez C, Hewinson G, Kremer K, Parsons LM, Pym AS, Samper S, van Soolingen D, Cole ST, A new evolutionary scenario for the Mycobacterium tuberculosis complex, Proc. Natl. Acad. Sci. U.S.A. 2002 Mar;99(6):3684-9.
• 2002
  Gordon SV, Brosch R, Eiglmeier K, Garnier T, Hewinson RG, Cole ST, Royal Society of Tropical Medicine and Hygiene Meeting at Manson House, London, 18th January 2001. Pathogen genomes and human health. Mycobacterial genomics, Trans. R. Soc. Trop. Med. Hyg. 2002 Jan-Feb;96(1):1-6.
• 2001
  Brosch R, Pym AS, Gordon SV, Cole ST, The evolution of mycobacterial pathogenicity: clues from comparative genomics, Trends Microbiol. 2001 Sep;9(9):452-8.
• 2001
  Gordon SV, Eiglmeier K, Garnier T, Brosch R, Parkhill J, Barrell B, Cole ST, Hewinson RG, Genomics of Mycobacterium bovis, Tuberculosis (Edinb) 2001;81(1-2):157-63.
• 2000
  Pym AS, Brosch R, Tools for the population genomics of the tubercle bacilli, Genome Res. 2000 Dec;10(12):1837-9.
• 2000
  Brosch R, Gordon SV, Buchrieser C, Pym AS, Garnier T, Cole ST, Comparative genomics uncovers large tandem chromosomal duplications in Mycobacterium bovis BCG Pasteur, Yeast 2000 Jun;17(2):111-23.
• 2000
  Brosch R, Gordon SV, Pym A, Eiglmeier K, Garnier T, Cole ST, Comparative genomics of the mycobacteria, Int. J. Med. Microbiol. 2000 May;290(2):143-52.
• 2000
  Brosch R, Gordon SV, Eiglmeier K, Garnier T, Cole ST, Comparative genomics of the leprosy and tubercle bacilli, Res. Microbiol. 2000 Mar;151(2):135-42.
• 1999
  Brosch R, Philipp WJ, Stavropoulos E, Colston MJ, Cole ST, Gordon SV, Genomic analysis reveals variation between Mycobacterium tuberculosis H37Rv and the attenuated M. tuberculosis H37Ra strain, Infect. Immun. 1999 Nov;67(11):5768-74.
• 1999
  Gordon SV, Brosch R, Billault A, Garnier T, Eiglmeier K, Cole ST, Identification of variable regions in the genomes of tubercle bacilli using bacterial artificial chromosome arrays, Mol. Microbiol. 1999 May;32(3):643-55.
• 1999
  Tekaia F, Gordon SV, Garnier T, Brosch R, Barrell BG, Cole ST, Analysis of the proteome of Mycobacterium tuberculosis in silico, Tuber. Lung Dis. 1999;79(6):329-42.
• 1998
  Buchrieser C, Brosch R, Bach S, Guiyoule A, Carniel E, The high-pathogenicity island of Yersinia pseudotuberculosis can be inserted into any of the three chromosomal asn tRNA genes, Mol. Microbiol. 1998 Dec;30(5):965-78.
• 1998
  Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S, Barry CE, Tekaia F, Badcock K, Basham D, Brown D, Chillingworth T, Connor R, Davies R, Devlin K, Feltwell T, Gentles S, Hamlin N, Holroyd S, Hornsby T, Jagels K, Krogh A, McLean J, Moule S, Murphy L, Oliver K, Osborne J, Quail MA, Rajandream MA, Rogers J, Rutter S, Seeger K, Skelton J, Squares R, Squares S, Sulston JE, Taylor K, Whitehead S, Barrell BG, Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence, Nature 1998 Jun;393(6685):537-44.
• 1998
  Brosch R, Gordon SV, Billault A, Garnier T, Eiglmeier K, Soravito C, Barrell BG, Cole ST, Use of a Mycobacterium tuberculosis H37Rv bacterial artificial chromosome library for genome mapping, sequencing, and comparative genomics, Infect. Immun. 1998 May;66(5):2221-9.
• 1997
  Buchrieser C, Brosch R, Buchrieser O, Kristl A, Luchansky JB, Kaspar CW, Genomic analyses of Salmonella enteritidis phage type 4 strains from Austria and phage type 8 strains from the United States, Zentralbl. Bakteriol. 1997 Feb;285(3):379-88.
• 1996
  Brosch R, Brett M, Catimel B, Luchansky JB, Ojeniyi B, Rocourt J, Genomic fingerprinting of 80 strains from the WHO multicenter international typing study of listeria monocytogenes via pulsed-field gel electrophoresis (PFGE), Int. J. Food Microbiol. 1996 Oct;32(3):343-55.
• 1996
  Faith NG, Shere JA, Brosch R, Arnold KW, Ansay SE, Lee MS, Luchansky JB, Kaspar CW, Prevalence and clonal nature of Escherichia coli O157:H7 on dairy farms in Wisconsin, Appl. Environ. Microbiol. 1996 May;62(5):1519-25.
• 1996
  Lee MS, Kaspar CW, Brosch R, Shere J, Luchansky JB, Genomic analysis using pulsed-field gel electrophoresis of Escherichia coli O157: H7 isolated from dairy calves during the United State National Dairy Heifer Evaluation Project (1992-1992), Vet. Microbiol. 1996 Feb;48(3-4):223-30.
• 1995
  Proctor ME, Brosch R, Mellen JW, Garrett LA, Kaspar CW, Luchansky JB, Use of pulsed-field gel electrophoresis to link sporadic cases of invasive listeriosis with recalled chocolate milk, Appl. Environ. Microbiol. 1995 Aug;61(8):3177-9.
• 1995
  Jacquet C, Catimel B, Brosch R, Buchrieser C, Dehaumont P, Goulet V, Lepoutre A, Veit P, Rocourt J, Investigations related to the epidemic strain involved in the French listeriosis outbreak in 1992, Appl. Environ. Microbiol. 1995 Jun;61(6):2242-6.
• 1994
  Brosch R, Chen J, Luchansky JB, Pulsed-field fingerprinting of listeriae: identification of genomic divisions for Listeria monocytogenes and their correlation with serovar, Appl. Environ. Microbiol. 1994 Jul;60(7):2584-92.
• 1993
  Chen J, Brosch R, Luchansky JB, Isolation and characterization of Listeria monocytogenes-specific nucleotide sequences, Appl. Environ. Microbiol. 1993 Dec;59(12):4367-70.
• 1993
  Buchrieser C, Brosch R, Catimel B, Rocourt J, Pulsed-field gel electrophoresis applied for comparing Listeria monocytogenes strains involved in outbreaks, Can. J. Microbiol. 1993 Apr;39(4):395-401.
• 1993
  Danielsson-Tham ML, Bille J, Brosch R, Buchrieser C, Persson K, Rocourt J, Schwarzkopf A, Tham W, Ursing J, Characterization of Listeria strains isolated from soft cheese, Int. J. Food Microbiol. 1993 Apr;18(2):161-6.
• 1992
  Brosch R, Buchrieser C, Sixl W, Rocourt J, [10 years foodborne listeriosis–an evaluation], Wien. Klin. Wochenschr. 1992;104(6):149-57.
• 1991
  Buchrieser C, Brosch R, Rocourt J, Use of pulsed field gel electrophoresis to compare large DNA-restriction fragments of Listeria monocytogenes strains belonging to serogroups 1/2 and 3, Int. J. Food Microbiol. 1991 Dec;14(3-4):297-304.
• 1991
  Brosch R, Buchrieser C, Sixl-Voigt B, Rocourt J, Use of pulsed field electrophoresis of DNA restriction fragments for comparing Listeria monocytogenes strains isolated from human infections and food in Austria, Zentralbl. Bakteriol. 1991 Oct;275(4):557-60.
• 1991
  Brosch R, Buchrieser C, Rocourt J, Subtyping of Listeria monocytogenes serovar 4b by use of low-frequency-cleavage restriction endonucleases and pulsed-field gel electrophoresis, Res. Microbiol. 1991 Jul-Aug;142(6):667-75.
• 1989
  Buchrieser V, Brosch R, Buchrieser C, Miorini T, Sixl W, On the drinking water situation on the Cape Verde Islands (Island of Santiago), J Hyg Epidemiol Microbiol Immunol 1989;33(1):35-43.
• 1989
  Sebek Z, Miorini I, Brosch R, Buchrieser C, Buchrieser V, Sixl W, Valova M, A survey of leptospirological studies carried out on the Cape Verde Islands, Geogr Med Suppl 1989;5:153-60.
• 1988
  Brosch R, Sixl W, Buchrieser C, Buchrieser V, Miorini T, Serological investigations in Q-fever and listeriosis of wild-living small mammals on the Cape Verde Islands, Geogr Med Suppl 1988;1:65-70.
• 1988
  Brosch R, Buchrieser C, Buchrieser V, Miorini T, Sixl W, Serological investigations for antibodies against Treponema pallidum on the Cape Verde Islands (Santiago and Santo Antao)–2. report, Geogr Med Suppl 1988;1:93-4.
• 1987
  Buchrieser C, Sixl W, Brosch R, Buchrieser V, Miorini T, Resistance to antibiotics in humans and animals on the Cape Verde Islands, J Hyg Epidemiol Microbiol Immunol 1987;31(3):269-78.