Présentation
One of the significant drivers of phenotypic heterogeneity is noise in gene expression, which in turn is greatly influenced by fluctuations in the number of RNA molecules. Subcellular visualization of RNA turnover and quality control can aid in gaining new insights into gene expression regulation and cell behavior under different growth and stress conditions. This can be effectively addressed using short-lived and aptamer-based fluorescent reporters in conjunction with time-lapse microfluidic microscopy.
