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Projets
CV
EDUCATION
- 2016 | EPHE Diploma, Life and Earth Sciences (M2 level), with honors | Ecole Pratique des Hautes Etudes, Paris, France.
- 2003 | Biochemistry Senior technician certificate | High school Uruguay France, Avon, France.
- 2000 | Scientific Baccalaureate, Life and Earth Sciences | General and technological high school Catherine and Raymond Janot, Sens, France.
PROFESSIONAL EXPERIENCE
- 2022 – today | Research Engineer | Unit molecular parasitology and signaling | Pasteur Institute, Paris, France.
- 2011 – 2022 | Senior research technician | Unit molecular parasitology and signaling | Pasteur Institute, Paris, France.
- 2009 – 2011 | Senior research technician | G5 Parasitic virulence | Pasteur Institute, Paris, France.
- 2005 – 2009 | Senior technician | Unit of Biochemistry and Genetics of Development | Pasteur Institute, Paris, France.
- 2004 | Senior technician | French Blood Establishment | Hospital Center, Sens, France.
- 2003 – 2004 | Senior technician | INSERM | Unit 396, Human immunogenetics, Paris, France.
SCIENTIFIC ACTIVITIES
- 10 publications | 1 patent | H-index: 7
- Oral presentations: WorldLeish7: 7th World Congress on Leishmaniasis, Cartagena, Colombia (2022) | Invited speaker (videoconference), Workshop: Genome editing in Leishmania based on CRISPR/Cas9 system, Tehran, Iran (2021) | WorldLeish6: 6th World Congress on Leishmaniasis, Toledo, Spain (2017) | Parasitology and Mycology departmental seminar, Paris, France (2013) | Swiss Trypanosomatid meeting, Lesyn, Switzerland (2010).
- Posters: Future of parasitology, Paris, France (2017) | BSP Autumn Symposium, Microbial protein targets: towards understanding and intervention, Durham, England, (2016) | Trypanosomatid parasites: from the field to the lab. III, Paris, France (2014) | Trypanosomatid parasites: From the Field to the Lab. II, Paris, France (2012) | BSP Spring Meeting including the Trypanosomiasis and Leishmaniasis Seminar, Glasgow, Scotland (2012) | Trypanosomatid parasites: From the Field to the Lab., Paris, France (2011).
SUPERVISING, TRAINING AND TEACHING ACTIVITIES
- RIIP trainees: Ali Ben-Cheikh (PhD), Pasteur Institute of Tunis (3 months, 2021-2022) | Mahmoud Nateghi-Rostami (Dr), Pasteur Institute of Iran (1 month, 2021) | Tahereh Taheri (Dr), Pasteur Institute of Iran (3 months, 2019) | Mingkuan Chen (PhD), Pasteur Institute of Shanghai (3 months, 2015).
- Master/internship: Aicha Stierlen (3 months, 2021-2022) | Paya N’diaye (2 months, 2016) | Jessica Leroux, (2 months, 2010) | Najiha Bilal Farooqi (2 months, 2010).
- Member of the educational project “Pasteur-Banlieues, Scientists of Tomorrow” which allows students of a middle school in the priority education network to discover the world of research (2019 – today)
ADMINISTRATIVE RESPONSIBILITIES AND EXPERTISE
- 2011 – today | Health and Safety correspondent.
- 2022 | Member of the evaluation committee, “Source to pay” call for proposals.
- 2020 – 2021 | Member of the test group, eLab POC.
- 2020 | Member of the evaluation committee, eLab call for proposals.
- 2015 – 2020 | Representative of the College of Technicians of the Parasites and Insect Vectors Department.
Publications
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2021In vitro identification of imidazo[1,2-a]pyrazine-based antileishmanial agents and evaluation of L. major casein kinase 1 inhibition., Eur J Med Chem 2021 Jan; 210(): 112956.
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2016From Drug Screening to Target Deconvolution: a Target-Based Drug Discovery Pipeline Using Leishmania Casein Kinase 1 Isoform 2 To Identify Compounds with Antileishmanial Activity., Antimicrob Agents Chemother 2016 05; 60(5): 2822-33.
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2014Transgenic analysis of the Leishmania MAP kinase MPK10 reveals an auto-inhibitory mechanism crucial for stage-regulated activity and parasite viability., PLoS Pathog 2014 Sep; 10(9): e1004347.
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2014Probing druggability and biological function of essential proteins in Leishmania combining facilitated null mutant and plasmid shuffle analyses., Mol Microbiol 2014 Jul; 93(1): 146-66.
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2014Pharmacological assessment defines Leishmania donovani casein kinase 1 as a drug target and reveals important functions in parasite viability and intracellular infection., Antimicrob Agents Chemother 2014 ; 58(3): 1501-15.
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2013Enrichment of Leishmania donovani ATP-binding proteins using a staurosporine capture compound., J Proteomics 2013 Jun; 86(): 97-104.
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2012The crystal structure of the MAP kinase LmaMPK10 from Leishmania major reveals parasite-specific features and regulatory mechanisms., Structure 2012 Oct; 20(10): 1649-60.
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2011Adaptation of a 2D in-gel kinase assay to trace phosphotransferase activities in the human pathogen Leishmania donovani., J Proteomics 2011 Aug; 74(9): 1644-51.
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2010Cyclosporin A treatment of Leishmania donovani reveals stage-specific functions of cyclophilins in parasite proliferation and viability., PLoS Negl Trop Dis 2010 Jun; 4(6): e729.
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2008Ectopic expression of AID in a non-B cell line triggers A:T and G:C point mutations in non-replicating episomal vectors., PLoS One 2008 Jan; 3(1): e1480.
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