Désolé, cet article est seulement disponible en anglais américain.
Cliquez pour voir le graph
Cliquez pour voir la ligne de temps
Ligne de temps
Inhibition of peptidoglycan assembly complexes
Ivo Gomperts Boneca (PI)
The peptidoglycan (PGN) is an essential macromolecule of bacteria composed of a glycan moiety cross-linked by small stem peptides. The assembly of this macromolecule is achieved by protein complexes that involve synthetases, scaffolding proteins […]
Biology and Genetics of Bacterial Cell Wall
Ivo Gomperts Boneca (PI)
Our research unit aims at studying peptidoglycan (PGN) metabolism to better understand how bacteria assemble a mature and essential PGN that confers rigidity and shape to the cell despite a highly dynamic process […]
2008 Habilitation à Diriger des Recherches, U. Paris Pierre et Marie Curie
2007-present Assistant Professor Institut Pasteur
2004-2007 Postdoctoral Fellow Institut Pasteur
1998-2003 Postdoctoral Fellow Harvard Medical School
1997-1998 Postdoctoral Fellow U. of Amsterdam
1997 PhD Life Sciences, U. of Amsterdam, The Netherlands
1992 MSc Chemistry, VU University Amsterdam, The Netherlands
After defending my thesis, I joined the laboratory of Jon Beckwith at Harvard Medical School as a postdoctoral fellow. I continued working on cell division in bacteria for 5 years. In 2004, I arrived at the Institut Pasteur to work with Tony Pugsley on Type II secretion and later started my own research team working on lipoprotein modification. I became a permanent scientist in 2007 and joined the laboratory directed by Ivo Gomperts Boneca in 2014.
2022A Defect in Lipoprotein Modification by Lgt Leads to Abnormal Morphology and Cell Death in Escherichia coli That Is Independent of Major Lipoprotein Lpp., J Bacteriol 2022 Sep; 204(9): e0016422.
2021Mode of action of lipoprotein modification enzymes-Novel antibacterial targets., Mol Microbiol 2021 03; 115(3): 356-365.
2020Click-Chemistry Based Fluorometric Assay for Apolipoprotein N-acyltransferase from Enzyme Characterization to High-Throughput Screening., J Vis Exp 2020 05; (159): .
2019A sensitive fluorescence-based assay to monitor enzymatic activity of the essential integral membrane protein Apolipoprotein N-acyltransferase (Lnt)., Sci Rep 2019 11; 9(1): 15978.
2017Structural insights into the mechanism of the membrane integral N-acyltransferase step in bacterial lipoprotein synthesis, Nat Commun 2017 Jul;8:15952.
2017Identification of Lipoproteins Using Globomycin and Radioactive Palmitate, Methods Mol. Biol. 2017;1615:75-80.
2015The molecular mechanism of bacterial lipoprotein modification–how, when and why?, FEMS Microbiol. Rev. 2015 Mar;39(2):246-61.
2015Residues located on membrane-embedded flexible loops are essential for the second step of the apolipoprotein N-acyltransferase reaction, Mol. Microbiol. 2015 Feb;95(4):692-705.
2012Getting in touch: microbial molecular devices for cell-cell and cell-surface interactions, Res. Microbiol. 2012 Nov-Dec;163(9-10):577-8.
2012N-acylation of lipoproteins: not when sour, J. Bacteriol. 2012 Jul;194(13):3297-8.
+Voir la liste complète de publications