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Inhibition of peptidoglycan assembly complexes
Ivo Gomperts Boneca (PI)
The peptidoglycan (PGN) is an essential macromolecule of bacteria composed of a glycan moiety cross-linked by small stem peptides. The assembly of this macromolecule is achieved by protein complexes that involve synthetases, scaffolding proteins […]
Biology and Genetics of Bacterial Cell Wall
Ivo Gomperts Boneca (PI)
Our research unit aims at studying peptidoglycan (PGN) metabolism to better understand how bacteria assemble a mature and essential PGN that confers rigidity and shape to the cell despite a highly dynamic process […]
2008 Habilitation à Diriger des Recherches, U. Paris Pierre et Marie Curie
2007-present Assistant Professor Institut Pasteur
2004-2007 Postdoctoral Fellow Institut Pasteur
1998-2003 Postdoctoral Fellow Harvard Medical School
1997-1998 Postdoctoral Fellow U. of Amsterdam
1997 PhD Life Sciences, U. of Amsterdam, The Netherlands
1992 MSc Chemistry, VU University Amsterdam, The Netherlands
After defending my thesis, I joined the laboratory of Jon Beckwith at Harvard Medical School as a postdoctoral fellow. I continued working on cell division in bacteria for 5 years. In 2004, I arrived at the Institut Pasteur to work with Tony Pugsley on Type II secretion and later started my own research team working on lipoprotein modification. I became a permanent scientist in 2007 and joined the laboratory directed by Ivo Gomperts Boneca in 2014.
2021Mode of action of lipoprotein modification enzymes-Novel antibacterial targets., Mol Microbiol 2021 03; 115(3): 356-365.
2020Click-Chemistry Based Fluorometric Assay for Apolipoprotein N-acyltransferase from Enzyme Characterization to High-Throughput Screening., J Vis Exp 2020 05; (159): .
2019A sensitive fluorescence-based assay to monitor enzymatic activity of the essential integral membrane protein Apolipoprotein N-acyltransferase (Lnt)., Sci Rep 2019 11; 9(1): 15978.
2017Structural insights into the mechanism of the membrane integral N-acyltransferase step in bacterial lipoprotein synthesis, Nat Commun 2017 Jul;8:15952.
2017Identification of Lipoproteins Using Globomycin and Radioactive Palmitate, Methods Mol. Biol. 2017;1615:75-80.
2015The molecular mechanism of bacterial lipoprotein modification–how, when and why?, FEMS Microbiol. Rev. 2015 Mar;39(2):246-61.
2015Residues located on membrane-embedded flexible loops are essential for the second step of the apolipoprotein N-acyltransferase reaction, Mol. Microbiol. 2015 Feb;95(4):692-705.
2012Getting in touch: microbial molecular devices for cell-cell and cell-surface interactions, Res. Microbiol. 2012 Nov-Dec;163(9-10):577-8.
2012N-acylation of lipoproteins: not when sour, J. Bacteriol. 2012 Jul;194(13):3297-8.
2012Phosphatidylglycerol::prolipoprotein diacylglyceryl transferase (Lgt) of Escherichia coli has seven transmembrane segments, and its essential residues are embedded in the membrane, J. Bacteriol. 2012 May;194(9):2142-51.
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