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Anciennes Équipes
CV
2008 Habilitation à Diriger des Recherches, U. Paris Pierre et Marie Curie
2007-present Assistant Professor Institut Pasteur
2004-2007 Postdoctoral Fellow Institut Pasteur
1998-2003 Postdoctoral Fellow Harvard Medical School
1997-1998 Postdoctoral Fellow U. of Amsterdam
1997 PhD Life Sciences, U. of Amsterdam, The Netherlands
1992 MSc Chemistry, VU University Amsterdam, The Netherlands
After defending my thesis, I joined the laboratory of Jon Beckwith at Harvard Medical School as a postdoctoral fellow. I continued working on cell division in bacteria for 5 years. In 2004, I arrived at the Institut Pasteur to work with Tony Pugsley on Type II secretion and later started my own research team working on lipoprotein modification. I became a permanent scientist in 2007 and joined the laboratory directed by Ivo Gomperts Boneca in 2014.
Publications
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2023Components Subcellular Localization: Identification of Lipoproteins Using Alkyne Fatty Acids and Click Chemistry, E. Cascales; L. Journet. Bacterial Secretion Systems, 2715, Springer US, pp.79-89, 2023, Methods in Molecular Biology, 978-1-0716-3444-8. ⟨10.1007/978-1-0716-3445-5_5⟩.
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2023Components Subcellular Localization: Identification of Lipoproteins Using Globomycin and Radioactive Palmitate, Laure Journet; Eric Cascales. Bacterial Secretion Systems, 2715, Springer US, 2023, Methods in Molecular Biology, 978-1-0716-3444-8. ⟨10.1007/978-1-0716-3445-5_4⟩.
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2022A Defect in Lipoprotein Modification by Lgt Leads to Abnormal Morphology and Cell Death in Escherichia coli That Is Independent of Major Lipoprotein Lpp, Journal of Bacteriology, 2022, 204 (9), pp.e0016422. ⟨10.1128/jb.00164-22⟩.
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2021Mode of action of lipoprotein modification enzymes—Novel antibacterial targets, Molecular Microbiology, 2020, 115 (3), pp.356 - 365. ⟨10.1111/mmi.14610⟩.
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2021Editorial : Post-translational modifications in bacteria – The dynamics of bacterial physiology, Research in Microbiology, 2021, 172 (7-8), pp. 103887. ⟨10.1016/j.resmic.2021.103887⟩.
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2020Click-Chemistry Based Fluorometric Assay for Apolipoprotein N-acyltransferase from Enzyme Characterization to High-Throughput Screening, Journal of visualized experiments : JoVE, 2020, 159, ⟨10.3791/61146⟩.
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2019A sensitive fluorescence-based assay to monitor enzymatic activity of the essential integral membrane protein Apolipoprotein N-acyltransferase (Lnt), Scientific Reports, 2019, 9 (1), pp.15978. ⟨10.1038/s41598-019-52106-8⟩.
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2017Structural insights into the mechanism of the membrane integral N-acyltransferase step in bacterial lipoprotein synthesis., Nature Communications, 2017, 8, pp.15952. ⟨10.1038/ncomms15952⟩.
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2017Identification of Lipoproteins Using Globomycin and Radioactive Palmitate., Laure Journet et Eric Cascales Bacterial Protein Secretion Systems, 1615, Humana Press, pp.75-80, 2017, Methods in Molecular Biology, 978-1-4939-7033-9. ⟨10.1007/978-1-4939-7033-9_5⟩.
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2015The molecular mechanism of bacterial lipoprotein modification–how, when and why?, FEMS Microbiology Reviews, 2015, 39 (2), pp.246-61. ⟨10.1093/femsre/fuu006⟩.
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