Ludovic Deriano

Cancer cells frequently harbor somatic mutations leading to altered DNA repair pathways. In some cases, these defects can be therapeutically exploited as these tumor cells, but not healthy cells, rely on compensatory DNA repair […]

Chromosomal translocations can promote cancer development by disrupting tumor suppressors, activating oncogenes, or generating aberrant fusion proteins. Fusion genes are frequent in cancers and are used as diagnostic and prognostic tools to classify and […]

The malignant transformation of cells translates into a major worldwide health, social and economic burden. Efforts to define the etiology of cancer, along with the development of new therapeutic approaches to treat them, would […]

Deciphering the Oncogenic Lesions and Pathways of B and T Cell Cancers

  B and T cell lymphoid cancers are among the most common human malignancies. Many factors, endogenous and exogenous, are implicated in the etiology of these disorders, but key oncogenic lesions often arise through […]

  DNA double-strand breaks (DSBs), although common, are extremely dangerous (Deriano and Roth, Annual Review of Genetics, 2013). Unlike most other DNA lesions, DSBs directly threaten genomic integrity by disrupting the physical continuity of […]