Timeline
Olivier Leclercq
Research Engineer
27 Sep 2022
project
ANR Texleish: Targeting host-parasite interactions through the inhibition of excreted leishmania casein kinase 1
Read more22 Sep 2022
project
Pasteur-Weizmann project: Role of kinases in vesicle-mediated regulation of host-pathogen interactions: Focus on Leishmania donovani and Plasmodium falciparum.
Read more20 Sep 2022
project
Campus France procope: CASEIN KINASE 1, A KEY REGULATOR OF TUMORIGENESIS AND HOST-PATHOGEN INTERACTIONS
Read more08 Feb 2022
15 Jan 2021
publication
In vitro identification of imidazo[1,2-a]pyrazine-based antileishmanial agents and evaluation of L. major casein kinase 1 inhibition.
Read more01 May 2016
publication
From Drug Screening to Target Deconvolution: a Target-Based Drug Discovery Pipeline Using Leishmania Casein Kinase 1 Isoform 2 To Identify Compounds with Antileishmanial Activity.
Read more14 Sep 2015
07 Sep 2015
project
FP7 Targeting the Leishmania kinome for the development of novel anti-parasitic strategies (LeishDrug)
Read more07 Sep 2015
project
ANR TransLeish – Discovery of druggable protein kinases in the protozoan parasite Leishmania donovani using hit compounds identified by phenotypic screening
Read more11 May 2015
01 Sep 2014
publication
Transgenic analysis of the Leishmania MAP kinase MPK10 reveals an auto-inhibitory mechanism crucial for stage-regulated activity and parasite viability.
Read more01 Jul 2014
publication
Probing druggability and biological function of essential proteins in Leishmania combining facilitated null mutant and plasmid shuffle analyses.
Read more01 Jan 2014
publication
Pharmacological assessment defines Leishmania donovani casein kinase 1 as a drug target and reveals important functions in parasite viability and intracellular infection.
Read more16 May 2013
publication
Enrichment of Leishmania donovani ATP-binding proteins using a staurosporine capture compound.
Read more09 Aug 2012
publication
The crystal structure of the MAP kinase LmaMPK10 from Leishmania major reveals parasite-specific features and regulatory mechanisms.
Read more26 Mar 2011
publication
Adaptation of a 2D in-gel kinase assay to trace phosphotransferase activities in the human pathogen Leishmania donovani.
Read more29 Jun 2010
publication
Cyclosporin A treatment of Leishmania donovani reveals stage-specific functions of cyclophilins in parasite proliferation and viability.
Read more23 Jan 2008
publication