Ligne de temps
Olivier Leclercq
Ingénieur(e) de Recherche
27 sept. 2022
project
ANR Texleish: Targeting host-parasite interactions through the inhibition of excreted leishmania casein kinase 1
Lire plus22 sept. 2022
project
Pasteur-Weizmann project: Role of kinases in vesicle-mediated regulation of host-pathogen interactions: Focus on Leishmania donovani and Plasmodium falciparum.
Lire plus20 sept. 2022
project
Campus France procope: CASEIN KINASE 1, A KEY REGULATOR OF TUMORIGENESIS AND HOST-PATHOGEN INTERACTIONS
Lire plus08 févr. 2022
15 janv. 2021
publication
In vitro identification of imidazo[1,2-a]pyrazine-based antileishmanial agents and evaluation of L. major casein kinase 1 inhibition.
Lire plus01 mai 2016
publication
From Drug Screening to Target Deconvolution: a Target-Based Drug Discovery Pipeline Using Leishmania Casein Kinase 1 Isoform 2 To Identify Compounds with Antileishmanial Activity.
Lire plus14 sept. 2015
07 sept. 2015
project
FP7 Targeting the Leishmania kinome for the development of novel anti-parasitic strategies (LeishDrug)
Lire plus07 sept. 2015
project
ANR TransLeish – Discovery of druggable protein kinases in the protozoan parasite Leishmania donovani using hit compounds identified by phenotypic screening
Lire plus11 mai 2015
01 sept. 2014
publication
Transgenic analysis of the Leishmania MAP kinase MPK10 reveals an auto-inhibitory mechanism crucial for stage-regulated activity and parasite viability.
Lire plus01 juil. 2014
publication
Probing druggability and biological function of essential proteins in Leishmania combining facilitated null mutant and plasmid shuffle analyses.
Lire plus01 janv. 2014
publication
Pharmacological assessment defines Leishmania donovani casein kinase 1 as a drug target and reveals important functions in parasite viability and intracellular infection.
Lire plus16 mai 2013
publication
Enrichment of Leishmania donovani ATP-binding proteins using a staurosporine capture compound.
Lire plus09 août 2012
publication
The crystal structure of the MAP kinase LmaMPK10 from Leishmania major reveals parasite-specific features and regulatory mechanisms.
Lire plus26 mars 2011
publication
Adaptation of a 2D in-gel kinase assay to trace phosphotransferase activities in the human pathogen Leishmania donovani.
Lire plus29 juin 2010
publication
Cyclosporin A treatment of Leishmania donovani reveals stage-specific functions of cyclophilins in parasite proliferation and viability.
Lire plus23 janv. 2008
publication