Timeline

Fabrice Agou

Head of Facility

19 Oct 2024

publication

Generation of IPi002-A/B/C human induced pluripotent stem cell lines from MARCH amniotic fluid cells.

12 Jul 2024

event

3rd Drug Discovery & Screening Symposium – “Innovative Therapeutics: Small Molecules and Biologics in Modern Medicine” – an ATC-DDS initiative

21 Jun 2024

publication

High-throughput screening identifies broad-spectrum Coronavirus entry inhibitors.

01 Apr 2024

publication

Generation of IPi001-A/B/C human induced pluripotent stem cell lines from healthy amniotic fluid cells.

06 Jan 2024

publication

PvDBPII elicits multiple antibody-mediated mechanisms that reduce growth in a Plasmodium vivax challenge trial.

27 Oct 2023

event

ATC-DDS Seminar – “Epigenetic regulation: at the apex of Innate Immune Memory” – Pr. Musa M. Mhlanga (Radboud University, Netherlands)

13 Jul 2023

event

2nd Drug Discovery & Screening Symposium – “From bench to drug discovery” – an ATC-DDS initiative

21 Apr 2023

publication

Enhanced neutralization escape to therapeutic monoclonal antibodies by SARS-CoV-2 omicron sub-lineages.

22 Mar 2023

publication

Design and synthesis of naturally-inspired SARS-CoV-2 inhibitors.

30 Nov 2022

publication

High-Content RNAi Phenotypic Screening Unveils the Involvement of Human Ubiquitin-Related Enzymes in Late Cytokinesis

29 Aug 2022

program_project

Drug Discovery & Screening at Institut Pasteur

04 Jul 2022

publication

Potent human broadly SARS-CoV-2-neutralizing IgA and IgG antibodies effective against Omicron BA.1 and BA.2.

17 Jun 2022

news

New publication – Potent Human Broadly SARS-CoV-2 Neutralizing IgA and IgG Antibodies Effective Against Omicron BA.1 and BA.2

01 May 2022

publication

A highly sensitive cell-based luciferase assay for high-throughput automated screening of SARS-CoV-2 nsp5/3CLpro inhibitors.

27 Sep 2021

publication

Interrogating RNA and protein spatial subcellular distribution in smFISH data with DypFISH

21 Sep 2021

publication

Characterising proteolysis during SARS-CoV-2 infection identifies viral cleavage sites and cellular targets with therapeutic potential.

04 Nov 2019

publication

A sensitive fluorescence-based assay to monitor enzymatic activity of the essential integral membrane protein Apolipoprotein N-acyltransferase (Lnt)

25 Sep 2019

publication

Two NEMO-like Ubiquitin-Binding Domains in CEP55 Differently Regulate Cytokinesis.

29 Jan 2019

event

Virology Department Seminar : « Molecular mechanisms of enterovirus infection and search for anti-virals » with Varpu MARJOMÄKI

13 Dec 2017

event

Scientific Day on Genome Editing Technology : CRISPR-Cas9 Seminar

13 Dec 2017

event

Advancing scientific innovations with ECHO Acoustic Liquid Handling

13 Dec 2017

event

The power of CRISPR-Cas9 arrayed screen using synthetic crRNA libraries

27 Feb 2017

publication

Lack of interaction between NEMO and SHARPIN impairs linear ubiquitination and NF-κB activation and leads to incontinentia pigmenti.

02 Sep 2016

publication

Super-resolution microscopy reveals a preformed NEMO lattice structure that is collapsed in incontinentia pigmenti

27 Oct 2015

project

Microfluidics@Pasteur

05 Jun 2015

team

Chemogenomic and Biological Screening Platform (PF-CCB)

01 Feb 2015

publication

Use of fluorescence spectroscopy for quantitative investigations of ubiquitin interactions with the ubiquitin-binding domains of NEMO

01 Jan 2015

publication

In vivo protein cross-linking

20 Jan 2014

publication

TNF and IL-1 exhibit distinct ubiquitin requirements for inducing NEMO-IKK supramolecular structures.

23 Jul 2011

publication

Direct inhibition of NF-κB activation by peptide targeting the NOA ubiquitin binding domain of NEMO

23 Oct 2009

publication

DARPin-assisted crystallography of the CC2-LZ domain of NEMO reveals a coupling between dimerization and ubiquitin binding

25 Nov 2008

publication

The zinc finger of NEMO is a functional ubiquitin-binding domain

30 Jan 2008

publication

Solution structure of NEMO zinc finger and impact of an anhidrotic ectodermal dysplasia with immunodeficiency-related point mutation

01 Sep 2007

publication

Inhibition of NF-kappaB activation with designed ankyrin-repeat proteins targeting the ubiquitin-binding/oligomerization domain of NEMO

10 Apr 2007

publication

NEMO oligomerization in the dynamic assembly of the IkappaB kinase core complex

23 Apr 2004

publication

The trimerization domain of NEMO is composed of the interacting C-terminal CC2 and LZ coiled-coil subdomains

01 Jan 2004

publication

A little guide for advanced search:

Generation of IPi002-A/B/C human induced pluripotent stem cell lines from MARCH amniotic fluid cells.

3rd Drug Discovery & Screening Symposium – “Innovative Therapeutics: Small Molecules and Biologics in Modern Medicine” – an ATC-DDS initiative

High-throughput screening identifies broad-spectrum Coronavirus entry inhibitors.

Generation of IPi001-A/B/C human induced pluripotent stem cell lines from healthy amniotic fluid cells.

PvDBPII elicits multiple antibody-mediated mechanisms that reduce growth in a Plasmodium vivax challenge trial.

ATC-DDS Seminar – “Epigenetic regulation: at the apex of Innate Immune Memory” – Pr. Musa M. Mhlanga (Radboud University, Netherlands)

2nd Drug Discovery & Screening Symposium – “From bench to drug discovery” – an ATC-DDS initiative

Enhanced neutralization escape to therapeutic monoclonal antibodies by SARS-CoV-2 omicron sub-lineages.

Design and synthesis of naturally-inspired SARS-CoV-2 inhibitors.

High-Content RNAi Phenotypic Screening Unveils the Involvement of Human Ubiquitin-Related Enzymes in Late Cytokinesis

Drug Discovery & Screening at Institut Pasteur

Potent human broadly SARS-CoV-2-neutralizing IgA and IgG antibodies effective against Omicron BA.1 and BA.2.

New publication – Potent Human Broadly SARS-CoV-2 Neutralizing IgA and IgG Antibodies Effective Against Omicron BA.1 and BA.2

A highly sensitive cell-based luciferase assay for high-throughput automated screening of SARS-CoV-2 nsp5/3CLpro inhibitors.

Interrogating RNA and protein spatial subcellular distribution in smFISH data with DypFISH

Characterising proteolysis during SARS-CoV-2 infection identifies viral cleavage sites and cellular targets with therapeutic potential.

A sensitive fluorescence-based assay to monitor enzymatic activity of the essential integral membrane protein Apolipoprotein N-acyltransferase (Lnt)

Two NEMO-like Ubiquitin-Binding Domains in CEP55 Differently Regulate Cytokinesis.

Virology Department Seminar : « Molecular mechanisms of enterovirus infection and search for anti-virals » with Varpu MARJOMÄKI

Scientific Day on Genome Editing Technology : CRISPR-Cas9 Seminar

Advancing scientific innovations with ECHO Acoustic Liquid Handling

The power of CRISPR-Cas9 arrayed screen using synthetic crRNA libraries

Lack of interaction between NEMO and SHARPIN impairs linear ubiquitination and NF-κB activation and leads to incontinentia pigmenti.

Super-resolution microscopy reveals a preformed NEMO lattice structure that is collapsed in incontinentia pigmenti

Microfluidics@Pasteur

Chemogenomic and Biological Screening Platform (PF-CCB)

Use of fluorescence spectroscopy for quantitative investigations of ubiquitin interactions with the ubiquitin-binding domains of NEMO

In vivo protein cross-linking

TNF and IL-1 exhibit distinct ubiquitin requirements for inducing NEMO-IKK supramolecular structures.

Direct inhibition of NF-κB activation by peptide targeting the NOA ubiquitin binding domain of NEMO

DARPin-assisted crystallography of the CC2-LZ domain of NEMO reveals a coupling between dimerization and ubiquitin binding

The zinc finger of NEMO is a functional ubiquitin-binding domain

Solution structure of NEMO zinc finger and impact of an anhidrotic ectodermal dysplasia with immunodeficiency-related point mutation

Inhibition of NF-kappaB activation with designed ankyrin-repeat proteins targeting the ubiquitin-binding/oligomerization domain of NEMO

NEMO oligomerization in the dynamic assembly of the IkappaB kinase core complex

The trimerization domain of NEMO is composed of the interacting C-terminal CC2 and LZ coiled-coil subdomains

In vivo protein cross-linking