Ligne de temps

Fabrice Agou
Responsable de Plateforme
19 oct. 2024
publication

Generation of IPi002-A/B/C human induced pluripotent stem cell lines from MARCH amniotic fluid cells.

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12 juil. 2024
event

3rd Drug Discovery & Screening Symposium – “Innovative Therapeutics: Small Molecules and Biologics in Modern Medicine” – an ATC-DDS initiative

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21 juin 2024
publication

High-throughput screening identifies broad-spectrum Coronavirus entry inhibitors.

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01 avr. 2024
publication

Generation of IPi001-A/B/C human induced pluripotent stem cell lines from healthy amniotic fluid cells.

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06 janv. 2024
publication

PvDBPII elicits multiple antibody-mediated mechanisms that reduce growth in a Plasmodium vivax challenge trial.

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27 oct. 2023
event

ATC-DDS Seminar – “Epigenetic regulation: at the apex of Innate Immune Memory” – Pr. Musa M. Mhlanga (Radboud University, Netherlands)

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13 juil. 2023
event

2nd Drug Discovery & Screening Symposium – “From bench to drug discovery” – an ATC-DDS initiative

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21 avr. 2023
publication

Enhanced neutralization escape to therapeutic monoclonal antibodies by SARS-CoV-2 omicron sub-lineages.

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22 mars 2023
publication

Design and synthesis of naturally-inspired SARS-CoV-2 inhibitors.

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30 nov. 2022
publication

High-Content RNAi Phenotypic Screening Unveils the Involvement of Human Ubiquitin-Related Enzymes in Late Cytokinesis

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29 août 2022
program_project

Le criblage de molécules à l’Institut Pasteur

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04 juil. 2022
publication

Potent human broadly SARS-CoV-2-neutralizing IgA and IgG antibodies effective against Omicron BA.1 and BA.2.

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17 juin 2022
news

New publication – Potent Human Broadly SARS-CoV-2 Neutralizing IgA and IgG Antibodies Effective Against Omicron BA.1 and BA.2

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01 mai 2022
publication

A highly sensitive cell-based luciferase assay for high-throughput automated screening of SARS-CoV-2 nsp5/3CLpro inhibitors.

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27 sept. 2021
publication

Interrogating RNA and protein spatial subcellular distribution in smFISH data with DypFISH

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21 sept. 2021
publication

Characterising proteolysis during SARS-CoV-2 infection identifies viral cleavage sites and cellular targets with therapeutic potential.

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04 nov. 2019
publication

A sensitive fluorescence-based assay to monitor enzymatic activity of the essential integral membrane protein Apolipoprotein N-acyltransferase (Lnt)

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25 sept. 2019
publication

Two NEMO-like Ubiquitin-Binding Domains in CEP55 Differently Regulate Cytokinesis.

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29 janv. 2019
event

Virology Department Seminar : « Molecular mechanisms of enterovirus infection and search for anti-virals » with Varpu MARJOMÄKI

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13 déc. 2017
event

Scientific Day on Genome Editing Technology : CRISPR-Cas9 Seminar

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13 déc. 2017
event

Advancing scientific innovations with ECHO Acoustic Liquid Handling

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13 déc. 2017
event

The power of CRISPR-Cas9 arrayed screen using synthetic crRNA libraries

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27 févr. 2017
publication

Lack of interaction between NEMO and SHARPIN impairs linear ubiquitination and NF-κB activation and leads to incontinentia pigmenti.

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02 sept. 2016
publication

Super-resolution microscopy reveals a preformed NEMO lattice structure that is collapsed in incontinentia pigmenti

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27 oct. 2015
project

Microfluidics@Pasteur

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05 juin 2015
team

Plateforme de Criblage Chémogénomique et Biologique (PF-CCB)

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01 févr. 2015
publication

Use of fluorescence spectroscopy for quantitative investigations of ubiquitin interactions with the ubiquitin-binding domains of NEMO

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01 janv. 2015
publication

In vivo protein cross-linking

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20 janv. 2014
publication

TNF and IL-1 exhibit distinct ubiquitin requirements for inducing NEMO-IKK supramolecular structures.

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23 juil. 2011
publication

Direct inhibition of NF-κB activation by peptide targeting the NOA ubiquitin binding domain of NEMO

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23 oct. 2009
publication

DARPin-assisted crystallography of the CC2-LZ domain of NEMO reveals a coupling between dimerization and ubiquitin binding

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25 nov. 2008
publication

The zinc finger of NEMO is a functional ubiquitin-binding domain

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30 janv. 2008
publication

Solution structure of NEMO zinc finger and impact of an anhidrotic ectodermal dysplasia with immunodeficiency-related point mutation

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01 sept. 2007
publication

Inhibition of NF-kappaB activation with designed ankyrin-repeat proteins targeting the ubiquitin-binding/oligomerization domain of NEMO

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10 avr. 2007
publication

NEMO oligomerization in the dynamic assembly of the IkappaB kinase core complex

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23 avr. 2004
publication

The trimerization domain of NEMO is composed of the interacting C-terminal CC2 and LZ coiled-coil subdomains

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01 janv. 2004
publication

In vivo protein cross-linking

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