Timeline

Pablo Guardado-Calvo

Head of Structure

18 Aug 2025

publication

Structural basis of poxvirus fusion regulation and anti-A16/G9 antibody-mediated neutralization and protection.

01 Jul 2025

publication

Modulation of SARS-CoV-2 spike binding to ACE2 through conformational selection.

15 Apr 2025

publication

Monkeypox Virus Infection Stimulates a More Robust and Durable Neutralizing Antibody Response Compared to Modified Vaccinia Virus Ankara Vaccination.

06 Mar 2025

publication

On the role of VP3-PI3P interaction in birnavirus endosomal membrane targeting.

01 Feb 2025

publication

Disruption of deoxyribonucleotide triphosphate biosynthesis leads to RAS proto-oncogene activation and perturbation of mitochondrial metabolism.

01 Feb 2025

publication

Disruption of deoxyribonucleotide triphosphate biosynthesis leads to RAS proto-oncogene activation and perturbation of mitochondrial metabolism

23 Jan 2025

publication

Antiviral activity of tecovirimat against monkeypox virus clades 1a, 1b, 2a, and 2b.

01 Jan 2025

publication

Structural insights into tecovirimat antiviral activity and poxvirus resistance.

01 Jan 2025

publication

Puumala orthohantavirus: prevalence, biology, disease, animal models and recent advances in therapeutics development and structural biology.

19 Jul 2024

publication

Broad sarbecovirus neutralization by combined memory B cell antibodies to ancestral SARS-CoV-2.

01 Jan 2024

publication

Production and Purification of Hantavirus Glycoproteins in Drosophila melanogaster S2 Cells.

08 Dec 2023

publication

Neutralization Determinants on Poxviruses.

24 Jul 2023

publication

Two point mutations in protocadherin-1 disrupt hantavirus recognition and afford protection against lethal infection.

14 Jun 2023

publication

Structural and mechanistic basis of neutralization by a pan-hantavirus protective antibody.

28 Mar 2023

publication

Structure, function, and evolution of the Orthobunyavirus membrane fusion glycoprotein.

27 Mar 2023

publication

Antigenic mapping and functional characterization of human New World hantavirus neutralizing antibodies.

13 Jan 2023

publication

A Search for Tick-Associated, Bronnoya-like Virus Spillover into Sheep.

04 Jan 2023

team

Structural biology of infectious diseases

01 Jan 2023

publication

Diversity of Viruses in Ixodes ricinus in Europe including Novel and Potential Arboviruses.

04 Jul 2022

publication

Potent human broadly SARS-CoV-2-neutralizing IgA and IgG antibodies effective against Omicron BA.1 and BA.2.

17 Jun 2022

news

New publication – Potent Human Broadly SARS-CoV-2 Neutralizing IgA and IgG Antibodies Effective Against Omicron BA.1 and BA.2

16 Mar 2022

publication

Human antibody recognizing a quaternary epitope in the Puumala virus glycoprotein provides broad protection against orthohantaviruses.

07 Jan 2022

publication

Structural basis of synergistic neutralization of Crimean-Congo hemorrhagic fever virus by human antibodies.

01 Jan 2022

publication

Editorial: Influence of Protein-Protein Interactions (PPIs) on the Outcome of Viral Infections.

09 Dec 2021

publication

The epitope arrangement on flavivirus particles contributes to Mab C10’s extraordinary neutralization breadth across Zika and dengue viruses.

26 Nov 2021

publication

The Viral Class II Membrane Fusion Machinery: Divergent Evolution from an Ancestral Heterodimer.

01 Oct 2021

publication

The surface glycoproteins of hantaviruses.

01 Sep 2021

publication

Human herpesvirus 8 molecular mimicry of ephrin ligands facilitates cell entry and triggers EphA2 signaling.

01 Jan 2021

publication

Generation of plasma cells and CD27-IgD- B cells during hantavirus infection is associated with distinct pathological findings.

15 Oct 2020

publication

The Hantavirus Surface Glycoprotein Lattice and Its Fusion Control Mechanism.

21 Apr 2020

publication

Multimeric single-domain antibody complexes protect against bunyavirus infections.

10 Apr 2020

project

CORONABODIES

10 Jun 2019

publication

Molecular organization and dynamics of the fusion protein Gc at the hantavirus surface.

20 Feb 2019

publication

Orthobunyavirus spike architecture and recognition by neutralizing antibodies.

01 Jan 2019

publication

Reverse Immunology Approach to Define a New HIV-gp41-Neutralizing Epitope.

01 Nov 2018

publication

Protocadherin-1 is essential for cell entry by New World hantaviruses.

01 Jan 2018

publication

Structure-Function Dissection of Pseudorabies Virus Glycoprotein B Fusion Loops.

03 Nov 2017

publication

A glycerophospholipid-specific pocket in the RVFV class II fusion protein drives target membrane insertion.

23 May 2017

publication

Covalently linked dengue virus envelope glycoprotein dimers reduce exposure of the immunodominant fusion loop epitope.

01 Jan 2017

publication

The Envelope Proteins of the Bunyavirales.

01 Oct 2016

publication

Mechanistic Insight into Bunyavirus-Induced Membrane Fusion from Structure-Function Analyses of the Hantavirus Envelope Glycoprotein Gc.

02 Apr 2015

publication

Recognition determinants of broadly neutralizing human antibodies against dengue viruses.

01 Oct 2014

publication

Robust and low cost uniform (15)N-labeling of proteins expressed in Drosophila S2 cells and Spodoptera frugiperda Sf9 cells for NMR applications.

01 Oct 2012

publication

High-resolution structures of Thermus thermophilus enoyl-acyl carrier protein reductase in the apo form, in complex with NAD+ and in complex with NAD+ and triclosan.

01 Oct 2010

publication

Crystallographic structure of porcine adenovirus type 4 fiber head and galectin domains.

14 Jan 2010

publication

Synthesis and biological evaluation of new nanomolar competitive inhibitors of Helicobacter pylori type II dehydroquinase. Structural details of the role of the aromatic moieties with essential residues.

01 Nov 2009

publication

Crystallization of the head and galectin-like domains of porcine adenovirus isolate NADC-1 fibre.

01 Mar 2009

publication

Crystallographic structure of the alpha-helical triple coiled-coil domain of avian reovirus S1133 fibre.

01 Nov 2008

publication

Crystal structure of the avian reovirus inner capsid protein sigmaA.

01 Sep 2007

publication

Structure of the C-terminal head domain of the fowl adenovirus type 1 long fiber.

01 May 2007

publication

Crystallization of the avian reovirus double-stranded RNA-binding and core protein sigmaA.

01 May 2006

publication

Crystallization of the C-terminal head domain of the avian adenovirus CELO long fibre.

18 Nov 2005

publication

Structure of the carboxy-terminal receptor-binding domain of avian reovirus fibre sigmaC.

01 Jul 2005

publication

A little guide for advanced search:

Structural basis of poxvirus fusion regulation and anti-A16/G9 antibody-mediated neutralization and protection.

Modulation of SARS-CoV-2 spike binding to ACE2 through conformational selection.

Monkeypox Virus Infection Stimulates a More Robust and Durable Neutralizing Antibody Response Compared to Modified Vaccinia Virus Ankara Vaccination.

On the role of VP3-PI3P interaction in birnavirus endosomal membrane targeting.

Disruption of deoxyribonucleotide triphosphate biosynthesis leads to RAS proto-oncogene activation and perturbation of mitochondrial metabolism.

Disruption of deoxyribonucleotide triphosphate biosynthesis leads to RAS proto-oncogene activation and perturbation of mitochondrial metabolism

Antiviral activity of tecovirimat against monkeypox virus clades 1a, 1b, 2a, and 2b.

Structural insights into tecovirimat antiviral activity and poxvirus resistance.

Puumala orthohantavirus: prevalence, biology, disease, animal models and recent advances in therapeutics development and structural biology.

Broad sarbecovirus neutralization by combined memory B cell antibodies to ancestral SARS-CoV-2.

Production and Purification of Hantavirus Glycoproteins in Drosophila melanogaster S2 Cells.

Neutralization Determinants on Poxviruses.

Two point mutations in protocadherin-1 disrupt hantavirus recognition and afford protection against lethal infection.

Structural and mechanistic basis of neutralization by a pan-hantavirus protective antibody.

Structure, function, and evolution of the Orthobunyavirus membrane fusion glycoprotein.

Antigenic mapping and functional characterization of human New World hantavirus neutralizing antibodies.

A Search for Tick-Associated, Bronnoya-like Virus Spillover into Sheep.

Structural biology of infectious diseases

Diversity of Viruses in Ixodes ricinus in Europe including Novel and Potential Arboviruses.

Potent human broadly SARS-CoV-2-neutralizing IgA and IgG antibodies effective against Omicron BA.1 and BA.2.

New publication – Potent Human Broadly SARS-CoV-2 Neutralizing IgA and IgG Antibodies Effective Against Omicron BA.1 and BA.2

Human antibody recognizing a quaternary epitope in the Puumala virus glycoprotein provides broad protection against orthohantaviruses.

Structural basis of synergistic neutralization of Crimean-Congo hemorrhagic fever virus by human antibodies.

Editorial: Influence of Protein-Protein Interactions (PPIs) on the Outcome of Viral Infections.

The epitope arrangement on flavivirus particles contributes to Mab C10’s extraordinary neutralization breadth across Zika and dengue viruses.

The Viral Class II Membrane Fusion Machinery: Divergent Evolution from an Ancestral Heterodimer.

The surface glycoproteins of hantaviruses.

Human herpesvirus 8 molecular mimicry of ephrin ligands facilitates cell entry and triggers EphA2 signaling.

Generation of plasma cells and CD27-IgD- B cells during hantavirus infection is associated with distinct pathological findings.

The Hantavirus Surface Glycoprotein Lattice and Its Fusion Control Mechanism.

Multimeric single-domain antibody complexes protect against bunyavirus infections.

CORONABODIES

Molecular organization and dynamics of the fusion protein Gc at the hantavirus surface.

Orthobunyavirus spike architecture and recognition by neutralizing antibodies.

Reverse Immunology Approach to Define a New HIV-gp41-Neutralizing Epitope.

Protocadherin-1 is essential for cell entry by New World hantaviruses.

Structure-Function Dissection of Pseudorabies Virus Glycoprotein B Fusion Loops.

A glycerophospholipid-specific pocket in the RVFV class II fusion protein drives target membrane insertion.

Covalently linked dengue virus envelope glycoprotein dimers reduce exposure of the immunodominant fusion loop epitope.

The Envelope Proteins of the Bunyavirales.

Mechanistic Insight into Bunyavirus-Induced Membrane Fusion from Structure-Function Analyses of the Hantavirus Envelope Glycoprotein Gc.

Recognition determinants of broadly neutralizing human antibodies against dengue viruses.

Robust and low cost uniform (15)N-labeling of proteins expressed in Drosophila S2 cells and Spodoptera frugiperda Sf9 cells for NMR applications.

High-resolution structures of Thermus thermophilus enoyl-acyl carrier protein reductase in the apo form, in complex with NAD+ and in complex with NAD+ and triclosan.

Crystallographic structure of porcine adenovirus type 4 fiber head and galectin domains.

Synthesis and biological evaluation of new nanomolar competitive inhibitors of Helicobacter pylori type II dehydroquinase. Structural details of the role of the aromatic moieties with essential residues.

Crystallization of the head and galectin-like domains of porcine adenovirus isolate NADC-1 fibre.

Crystallographic structure of the alpha-helical triple coiled-coil domain of avian reovirus S1133 fibre.

Crystal structure of the avian reovirus inner capsid protein sigmaA.

Structure of the C-terminal head domain of the fowl adenovirus type 1 long fiber.

Crystallization of the avian reovirus double-stranded RNA-binding and core protein sigmaA.

Crystallization of the C-terminal head domain of the avian adenovirus CELO long fibre.

Structure of the carboxy-terminal receptor-binding domain of avian reovirus fibre sigmaC.

Crystallization of the C-terminal globular domain of avian reovirus fibre.