Timeline

Jean-Marc Cavaillon

Honorary Professor

05 Nov 2021

course

Innate Immunity MOOC

27 Dec 2017

publication

Compartment diversity in innate immune reprogramming

06 Apr 2017

event

17th Congress of European Shock Society: numerous “premières”

30 Mar 2017

event

Bruno LEMAITRE – Infection & Epidemiology Department Seminar

18 Oct 2016

news

SEMINAR OF THE INFECTION & EPIDEMIOLOGY DEPARTMENT

12 Aug 2016

publication

Local Microenvironment Controls the Compartmentalization of NK Cell Responses during Systemic Inflammation in Mice

11 Jul 2016

publication

Administration of zinc chelators improves survival of mice infected with Aspergillus fumigatus both in monotherapy and in combination with caspofungin.

24 May 2016

publication

Reducing hypoxia and inflammation during invasive pulmonary aspergillosis by targeting the Interleukin-1 receptor.

16 May 2016

publication

Cathepsin B-Deficient Mice Resolve Leishmania major Inflammation Faster in a T Cell-Dependent Manner.

14 Apr 2016

publication

Infection-Mediated Priming of Phagocytes Protects against Lethal Secondary Aspergillus fumigatus Challenge.

17 Mar 2016

project

Role of Neuroinflammation in Adult Neurogenesis

05 Feb 2016

publication

Recent developments in severe sepsis research: from bench to bedside and back.

13 Oct 2015

project

Brain & Sepsis

01 Jul 2015

project

Status of circulating and airways-derived neutrophils in cystic fibrosis

01 Jul 2015

project

Molecular basis of leukocyte reprogramming during systemic inflammation

01 Jul 2015

project

Modulation of pro-inflammatory cytokine production

01 Jul 2015

project

Innate immunity against Leishmania major

01 Jul 2015

project

Innate immunity against Aspergillus fumigatus

01 Jul 2015

project

Endotoxin tolerance

01 Jul 2015

project

Cell signaling via toll-like receptors and Nod molecule

01 Jul 2015

project

Assessment of the inflammatory status of intensive care unit patients

12 Jun 2015

publication

The fiendish behavior of TNF can be counteracted by microRNA

01 Jan 2015

publication

Host response biomarkers in the diagnosis of sepsis: a general overview

13 Nov 2014

publication

TLR9 activation is triggered by the excess of stimulatory versus inhibitory motifs present in Trypanosomatidae DNA

14 Aug 2014

publication

Altered immune status of circulating T lymphocytes during sepsis: children also

01 Jun 2014

publication

Joseph Alouf (1929-2014)

05 Feb 2014

publication

CD24-triggered caspase-dependent apoptosis via mitochondrial membrane depolarization and reactive oxygen species production of human neutrophils is impaired in sepsis

31 Jan 2014

publication

Protective or deleterious role of scavenger receptors SR-A and CD36 on host resistance to Staphylococcus aureus depends on the site of infection

24 Dec 2013

publication

TLR-mediated activation of NK cells and their role in bacterial/viral immune responses in mammals

26 Feb 2013

publication

Interferon-γ and granulocyte/monocyte colony-stimulating factor production by natural killer cells involves different signaling pathways and the adaptor stimulator of interferon genes (STING)

12 Dec 2012

publication

Good and bad fever

01 Nov 2012

publication

Lung microenvironment contributes to the resistance of alveolar macrophages to develop tolerance to endotoxin*

14 Sep 2012

publication

Sir Marc Armand Ruffer and Giulio Bizzozero: the first reports on efferocytosis

23 Jul 2012

publication

The WalKR system controls major staphylococcal virulence genes and is involved in triggering the host inflammatory response

15 Jun 2012

publication

DNAemia detection by multiplex PCR and biomarkers for infection in systemic inflammatory response syndrome patients

07 May 2012

publication

NK cell tolerance to TLR agonists mediated by regulatory T cells after polymicrobial sepsis

30 Mar 2012

publication

Natural killer (NK) cells in antibacterial innate immunity: angels or devils?

16 Nov 2011

publication

Early Systemic Bacterial Dissemination and a Rapid Innate Immune Response Characterize Genetic Resistance to Plague of SEG Mice

31 May 2011

publication

The historical milestones in the understanding of leukocyte biology initiated by Elie Metchnikoff

05 Jan 2011

publication

Mechanisms of TNF induction by heat-killed Staphylococcus aureus differ upon the origin of mononuclear phagocytes

18 Jun 2010

publication

Immune status in sepsis: the bug, the site of infection and the severity can make the difference

21 May 2010

publication

Contribution of NOD2 to lung inflammation during Staphylococcus aureus-induced pneumonia

13 Apr 2010

publication

Differential down-regulation of HLA-DR on monocyte subpopulations during systemic inflammation

08 Apr 2010

publication

In vivo bioluminescence imaging and histopathopathologic analysis reveal distinct roles for resident and recruited immune effector cells in defense against invasive aspergillosis

15 Jan 2010

publication

Resilience to bacterial infection: difference between species could be due to proteins in serum

26 Aug 2009

publication

Biofilm-forming Pseudomonas aeruginosa bacteria undergo lipopolysaccharide structural modifications and induce enhanced inflammatory cytokine response in human monocytes

28 Jul 2009

publication

Translocation of bacterial NOD2 agonist and its link with inflammation

01 Jun 2009

publication

Monocyte TREM-1 membrane expression in non-infectious inflammation

01 Jan 2009

publication

Compensatory anti-inflammatory response syndrome

31 Oct 2008

publication

Wild-derived mouse strains, a valuable model to study B cell responses

01 Jan 2008

publication

Neutrophils in cystic fibrosis display a distinct gene expression pattern

03 Dec 2007

publication

Circulating and airway neutrophils in cystic fibrosis display different TLR expression and responsiveness to interleukin-10

15 Nov 2007

publication

The Bw cells, a novel B cell population conserved in the whole genus Mus

01 Sep 2007

publication

Sepsis mediators

01 Jun 2007

publication

Early events in innate immunity in the recognition of microbial pathogens

04 Apr 2007

publication

Stress molecules in sepsis and systemic inflammatory response syndrome

01 Jan 2007

publication

Determining the degree of immunodysregulation in sepsis

21 Nov 2006

publication

Contribution of phagocytosis and intracellular sensing for cytokine production by Staphylococcus aureus-activated macrophages

01 Sep 2006

publication

Up-regulation of MyD88s and SIGIRR, molecules inhibiting Toll-like receptor signaling, in monocytes from septic patients

01 Jan 2006

publication

Bench-to-bedside review: endotoxin tolerance as a model of leukocyte reprogramming in sepsis

01 Jan 2006

publication

Compartmentalization of the inflammatory response in sepsis and SIRS

01 Dec 2005

publication

Monocytes/macrophages and sepsis

01 Aug 2005

publication

Synergistic stimulation of human monocytes and dendritic cells by Toll-like receptor 4 and NOD1- and NOD2-activating agonists.

01 Jan 2005

publication

Adherence modifies the regulation of gene expression induced by interleukin-10

10 Dec 2004

publication

5-HT activates ERK MAP kinase in cultured-human peripheral blood mononuclear cells via 5-HT1A receptors

30 Nov 2004

publication

Corticoids normalize leukocyte production of macrophage migration inhibitory factor in septic shock

01 Sep 2004

publication

Bordetella pertussis adenylate cyclase-hemolysin induces interleukin-6 secretion by human tracheal epithelial cells

16 Mar 2004

publication

Compartmentalization of tolerance to endotoxin

01 Jan 2004

publication

Mechanisms of immunodysregulation in sepsis

01 Feb 2003

publication

Differential effect of serotonin on cytokine production in lipopolysaccharide-stimulated human peripheral blood mononuclear cells: involvement of 5-hydroxytryptamine2A receptors

01 Jan 2003

publication

Cytokine cascade in sepsis

01 Jan 2003

publication

Endotoxin tolerance: is there a clinical relevance?

01 Jan 2003

publication

Adherence influences monocyte responsiveness to interleukin-10

24 May 2002

publication

Gamma interferon and granulocyte/monocyte colony-stimulating factor prevent endotoxin tolerance in human monocytes by promoting interleukin-1 receptor-associated kinase expression and its association to MyD88 and not by modulating TLR4 expression

A little guide for advanced search:

Innate Immunity MOOC

Compartment diversity in innate immune reprogramming

17th Congress of European Shock Society: numerous “premières”

Bruno LEMAITRE – Infection & Epidemiology Department Seminar

SEMINAR OF THE INFECTION & EPIDEMIOLOGY DEPARTMENT

Local Microenvironment Controls the Compartmentalization of NK Cell Responses during Systemic Inflammation in Mice

Administration of zinc chelators improves survival of mice infected with Aspergillus fumigatus both in monotherapy and in combination with caspofungin.

Reducing hypoxia and inflammation during invasive pulmonary aspergillosis by targeting the Interleukin-1 receptor.

Cathepsin B-Deficient Mice Resolve Leishmania major Inflammation Faster in a T Cell-Dependent Manner.

Infection-Mediated Priming of Phagocytes Protects against Lethal Secondary Aspergillus fumigatus Challenge.

Role of Neuroinflammation in Adult Neurogenesis

Recent developments in severe sepsis research: from bench to bedside and back.

Brain & Sepsis

﻿Status of circulating and airways-derived neutrophils in cystic fibrosis

Molecular basis of leukocyte reprogramming during systemic inflammation

Modulation of pro-inflammatory cytokine production

Innate immunity against Leishmania major

Innate immunity against Aspergillus fumigatus

Endotoxin tolerance

Cell signaling via toll-like receptors and Nod molecule

Assessment of the inflammatory status of intensive care unit patients

The fiendish behavior of TNF can be counteracted by microRNA

Host response biomarkers in the diagnosis of sepsis: a general overview

TLR9 activation is triggered by the excess of stimulatory versus inhibitory motifs present in Trypanosomatidae DNA

Altered immune status of circulating T lymphocytes during sepsis: children also

Joseph Alouf (1929-2014)

CD24-triggered caspase-dependent apoptosis via mitochondrial membrane depolarization and reactive oxygen species production of human neutrophils is impaired in sepsis

Protective or deleterious role of scavenger receptors SR-A and CD36 on host resistance to Staphylococcus aureus depends on the site of infection

TLR-mediated activation of NK cells and their role in bacterial/viral immune responses in mammals

Interferon-γ and granulocyte/monocyte colony-stimulating factor production by natural killer cells involves different signaling pathways and the adaptor stimulator of interferon genes (STING)

Good and bad fever

Lung microenvironment contributes to the resistance of alveolar macrophages to develop tolerance to endotoxin*

Sir Marc Armand Ruffer and Giulio Bizzozero: the first reports on efferocytosis

The WalKR system controls major staphylococcal virulence genes and is involved in triggering the host inflammatory response

DNAemia detection by multiplex PCR and biomarkers for infection in systemic inflammatory response syndrome patients

NK cell tolerance to TLR agonists mediated by regulatory T cells after polymicrobial sepsis

Natural killer (NK) cells in antibacterial innate immunity: angels or devils?

Early Systemic Bacterial Dissemination and a Rapid Innate Immune Response Characterize Genetic Resistance to Plague of SEG Mice

The historical milestones in the understanding of leukocyte biology initiated by Elie Metchnikoff

Mechanisms of TNF induction by heat-killed Staphylococcus aureus differ upon the origin of mononuclear phagocytes

Immune status in sepsis: the bug, the site of infection and the severity can make the difference

Contribution of NOD2 to lung inflammation during Staphylococcus aureus-induced pneumonia

Differential down-regulation of HLA-DR on monocyte subpopulations during systemic inflammation

In vivo bioluminescence imaging and histopathopathologic analysis reveal distinct roles for resident and recruited immune effector cells in defense against invasive aspergillosis

Resilience to bacterial infection: difference between species could be due to proteins in serum

Biofilm-forming Pseudomonas aeruginosa bacteria undergo lipopolysaccharide structural modifications and induce enhanced inflammatory cytokine response in human monocytes

Translocation of bacterial NOD2 agonist and its link with inflammation

Monocyte TREM-1 membrane expression in non-infectious inflammation

Compensatory anti-inflammatory response syndrome

Wild-derived mouse strains, a valuable model to study B cell responses

Neutrophils in cystic fibrosis display a distinct gene expression pattern

Circulating and airway neutrophils in cystic fibrosis display different TLR expression and responsiveness to interleukin-10

The Bw cells, a novel B cell population conserved in the whole genus Mus

Sepsis mediators

Early events in innate immunity in the recognition of microbial pathogens

Stress molecules in sepsis and systemic inflammatory response syndrome

Determining the degree of immunodysregulation in sepsis

Contribution of phagocytosis and intracellular sensing for cytokine production by Staphylococcus aureus-activated macrophages

Up-regulation of MyD88s and SIGIRR, molecules inhibiting Toll-like receptor signaling, in monocytes from septic patients

Bench-to-bedside review: endotoxin tolerance as a model of leukocyte reprogramming in sepsis

Compartmentalization of the inflammatory response in sepsis and SIRS

Monocytes/macrophages and sepsis

Synergistic stimulation of human monocytes and dendritic cells by Toll-like receptor 4 and NOD1- and NOD2-activating agonists.

Adherence modifies the regulation of gene expression induced by interleukin-10

5-HT activates ERK MAP kinase in cultured-human peripheral blood mononuclear cells via 5-HT1A receptors

Corticoids normalize leukocyte production of macrophage migration inhibitory factor in septic shock

Bordetella pertussis adenylate cyclase-hemolysin induces interleukin-6 secretion by human tracheal epithelial cells

Compartmentalization of tolerance to endotoxin

Mechanisms of immunodysregulation in sepsis

Differential effect of serotonin on cytokine production in lipopolysaccharide-stimulated human peripheral blood mononuclear cells: involvement of 5-hydroxytryptamine2A receptors

Cytokine cascade in sepsis

Endotoxin tolerance: is there a clinical relevance?

Adherence influences monocyte responsiveness to interleukin-10

Gamma interferon and granulocyte/monocyte colony-stimulating factor prevent endotoxin tolerance in human monocytes by promoting interleukin-1 receptor-associated kinase expression and its association to MyD88 and not by modulating TLR4 expression

Status of circulating and airways-derived neutrophils in cystic fibrosis