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© Research
Publication : The Journal of infectious diseases

Compartmentalization of tolerance to endotoxin

Team: Archived: Cytokines and Inflammation
Member: Jean-Marc Cavaillon
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in The Journal of infectious diseases - 16 Mar 2004

Fitting C, Dhawan S, Cavaillon JM

Link to Pubmed [PMID] – 15031800

J. Infect. Dis. 2004 Apr;189(7):1295-303

Tolerance to endotoxin has been defined and analyzed either entirely in vivo or entirely in vitro. In contrast, the hyporeactivity of circulating leukocytes reported in patients with sepsis, and often referred to as the phenomenon of tolerance to endotoxin, is an ex vivo observation. Therefore, our objective was to set up an ex vivo model of tolerance to endotoxin.