Peripheral immune cells modulate brain activities in physiology, but they are rarely found in direct contact with the neural tissue. Similarly, microbial products can shape brain development and aging, yet no commensal bacteria are found in healthy brain. We hypothesize that such peripheral immune and microbial signals affect the brain remotely and indirectly, from its borders, anatomical structures, which separate the central nervous system from the periphery. We aim to identify mechanisms of such remote immune and microbial influence on the brain by focusing on the choroid plexus (blood-CSF barrier) and the skull marrow niche in the context of brain development, aging and disease.
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About
Members
Former Members
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Name
Position
2022
2022
SAENZ Daniel
undergraduate student
2022
2022
FAYAD Ariane
undergraduate student
2022
2022
LAMBERT Kyle
undergraduate student
2022
2022
SINGH Roshani
graduate student
2022
2022
NINOU Elpiniki
visiting scientist
2022
2023
MOURGUE D'ALGUE Laure
graduate student
2023
2023
ALVAREZ PUGA Martin
undergraduate student
2022
2023
DREW Simon
Scientist
2023
2024
PINCON Annaelle
graduate student
2024
2024
SARROU Emeric
undergraduate student
2023
2024
BASURCO-GOGRENA Leyre
post doc - visiting scientist
2023
2024
PEDONE Rubia
graduate student
2023
2024
MAIER Benjamin
Physician
2024
2024
JARI Imad
graduate student
2024
2024
PANGAN Andrei
undergraduate student
2024
2024
MURPHY-GALIEVSKY Géraldine
undergraduate student
2022
2024
ZEJNELI Orgeta
post doc
Projects
Transversal Project
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Publications
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2025Systems neuroimmunology: current bottlenecks, research priorities and future directions., Nat Immunol 2025 Mar; 26(3): 325-329.
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2025Immune control of brain physiology., Nat Rev Immunol 2025 Jan; (): .
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2024Not so aDAMant after all: Plasticity of phagocytic microglia., Immunity 2024 Jun; 57(6): 1189-1191.
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2023Bacterial capsular polysaccharides with antibiofilm activity share common biophysical and electrokinetic properties., Nat Commun 2023 May; 14(1): 2553.
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2022Microbial and immune factors regulate brain maintenance and aging., Curr Opin Neurobiol 2022 Jul; 76(): 102607.
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2022The interaction of CD4+ helper T cells with dendritic cells shapes the tumor microenvironment and immune checkpoint blockade response., Nat Cancer 2022 03; 3(3): 303-317.
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2022Isolation and Characterization of the Immune Cells from Micro-dissected Mouse Choroid Plexuses, JoVE J. 2022 ().
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2021XCR1+ type 1 conventional dendritic cells drive liver pathology in non-alcoholic steatohepatitis., Nat Med 2021 May; (): .
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2021NASH limits anti-tumour surveillance in immunotherapy-treated HCC., Nature 2021 Apr; 592(7854): 450-456.
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2021Meningeal lymphoid structures are activated under acute and chronic spinal cord pathologies., Life Sci Alliance 2021 Jan; 4(1): .
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