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Age-related hearing loss called presbycusis is caused by the aging of the hearing system. Half of the causes of presbycusis are hereditary, that is to say genetic. For the other half of the cases, […]

Can reading performance of dyslexic readers be improved with auditory rhythmic training?  A key ingredient for reading is the mapping of graphemes (letters) to phonemes (sounds). Thus, correct representation of speech sounds is critical […]

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Genetics of neural oscillations in the context of speech and language  Cortical oscillations play an important role in speech and language processing, namely the low gamma (25–35 Hz), theta (4–8 Hz) and delta (1–3 […]

Characterizing the development of neural mechanisms underlying the co-learning of speech perception and production Learning to speak, from simple babbling to the pronunciation of complex sentences, requires learning to combine articulatory movements with abstract […]

The study of neural oscillations using high-resolution electroencephalography (HR-EEG) has uncovered irregularities in the auditory processing of language in individuals with Autism Spectrum Disorder (ASD). We intend to investigate the potential use of EEG […]

Assembling the puzzle of the operating auditory hairbundle The hair bundles of the sensory cells play a central role in the processing of sounds by the cochlea. Various performances of auditory perception depend upon […]

All genes that we have identified as associated with deafness, except for the gene encoding pejvakin which is responsible for DFNB59, lead to a primary deficit in the peripheral auditory sensory system. An in-depth […]

Pr Christine PETIT was the coordinator of this 36 month project which included Pr E. Sylvester Vizi and Dr Tibor Zelles (partners from Institute of experimental medicine, Hungarian Academy of Science, Budapest, Hungary) as […]

Hearing impairment, the most frequent sensory deficit, has a dramatic economic impact on healthcare systems worldwide. The HearInNoise project will be focused on late onset and progressive hearing impairment, more amenable to therapy but […]

Severe to profound deafness affects one in 700 newborns. This disability also affects an additional one child in 1000 before adulthood, and 2.3% of the general population between 60 and 70. Moreover, 40% of […]

Human and mouse hereditary deafness Severe to profound deafness affects one in 700 newborns. This disability also affects an additional one child in 1000 before adulthood, and 2.3% of the general population between 60 […]

Programme Grands investissements d’avenir Sensory disorders significantly impact cognition, education, employment, autonomy and are associated with a heavy socio-economic burden (e.g. the combined cost of visual and auditory impairment is estimated at 600 billion […]

Project Naming-Decoder Picture naming decoding from intraoperative electrophysiological recordings during awake brain tumor surgery Anarthria is the inability to articulate intelligible speech. It can occur in the context of numerous brain pathologies and is […]

Our objective is to generate inner ear organoids that can recapitulate in vitro the initial steps of the cochlear epithelium formation. In particular, we aim at generating these organoids in a micro-environment that allows […]

The enlightenment of the deafness: an holistic approach of Usher syndrome Recherche Hospitalo-Universitaire en Santé Professor Christine Petit (Institut Pasteur, Collège de France, Inserm, UPMC) and Dr. Aziz El-Amraoui (Institut Pasteur, Inserm, UPMC) coordinate the […]

Mutations in the gene encoding Vlgr1 (Very large G-coupled Receptor protein 1) areresponsible for Usher Syndrome type 2C (USH2C). This autosomal recessive syndrome is characterized by congenital, moderate to severe hearing impairment and a […]

A cortico-computer interface to restore speech communication Project SpeakOut Language and being able to communicate is an integral part of being human. The importance of communication is perhaps most evident when it is hampered […]

The TherapUsher project funded by Retina-France is aimed at creating appropriate animal models for the USH1 retinal dystrophy. The Usher syndrome (USH) is the most prevalent cause of inherited deaf-blindness in humans. Three clinical […]

Blindness and deafness are the two most prevalent sensory impairments, each of which profoundly impact the life of the affected person, whether child or adult. Usher syndrome (USH), the main target of this project, […]