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Scientific Fields
Diseases
Organisms
Applications
Technique

Published in - 26 Apr 2022

Suvadip Mukherjee, Vannary Meas-Yedid, Marc Bokobza, Thibault Lagache, Alexandre Corthay, Jean-Christophe Olivo-Marin

Link to HAL – pasteur-03699893

Link to DOI – 10.1109/ISBI52829.2022.9761498

2022 IEEE 19th International Symposium on Biomedical Imaging (ISBI), Mar 2022, Kolkata, India. pp.1-5, ⟨10.1109/ISBI52829.2022.9761498⟩

A pattern analysis approach is proposed to model spatial interaction between the immune cells and the tumor islets within the tumor microenvironment. Embedded in a statistical null hypothesis paradigm, the proposed solution provides a novel mechanism to extract quantitative, system-level snapshot of the tumor microenvironment during immunotherapy. Experimental results on synthetic and real histopathological data suggest the potential of our technique in mining robust informatics from the spatial distribution of immune cells at different time-points during cancer treatment, and this could be potentially adopted in large-scale experimental studies in the future to objectively monitor disease progression and the patient’s response to immune therapy.