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© Research
Publication : 2022 IEEE 19th International Symposium on Biomedical Imaging (ISBI)

Spatial Analysis For Histopathology: A Statistical Approach

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in 2022 IEEE 19th International Symposium on Biomedical Imaging (ISBI) - 26 Apr 2022

Suvadip Mukherjee, Vannary Meas-Yedid, Marc Bokobza, Thibault Lagache, Alexandre Corthay and Jean-Christophe Olivo-Marin

Link to DOI – 10.1109/ISBI52829.2022.9761498

A pattern analysis approach is proposed to model spatial interaction between the immune cells and the islets of cancer cells within the tumor microenvironment. Embedded in a statistical null hypothesis paradigm, the proposed solution provides a novel mechanism to extract quantitative, system-level snap-shot of the tumor microenvironment during immunotherapy. Experimental results on synthetic and real histopathological data suggest the potential of our technique in mining robust information from the spatial distribution of immune cells at different time-points during cancer treatment. This statistical framework could be potentially adopted in future large-scale experimental studies to objectively monitor disease progression and the patient’s response to immune therapy.