Thibault Lagache (PhD)
Permanent Researcher
Institut Pasteur – Department of Cell Biology & Infection – BioImage Analysis Unit
25-28 rue du Docteur Roux, 75015 Paris – +33 (0)7 66 03 75 65
thibault.lagache@pasteur.fr – thibault.lagache76@gmail.com
EDUCATION
Lycée Jehan-Ango, Dieppe, France – Baccalaureate (2000) – Scientific section (Highest honors)
Lycée Corneille, Rouen, France – Classes Préparatoires (2000-2002) – Mathematics & Physics (MPSI/MP*)
Ecole des Ponts ParisTech, France – Engineering Degree (2006) – Applied Mathematics & Computer Sciences
UPMC Paris 6 – Master 2 (2006) – Numerical Analysis (Highest honors, rank 2/71)
UPMC Paris 6 – PhD (2009) – Applied Mathematics (Highest honors)
A.1 Professional experiences.
Since 07/2019: Permanent researcher – Institut Pasteur, Department of Cell Biology and Infection, BioImage Analysis Unit – CNRS UMR 3691. Paris, France
09/2016-06/2019 : Post-Doctoral Fellow – Columbia University, Department of Biological Sciences (P.I. Rafael Yuste) New-York, United States.
Project: Nanophysiology of synaptic transmission
Fellowships: Fondation Pour la Recherche Médicale (09-2016->09/2017, 30,000 €),Philippe Foundation (09-2016->09/2017, 7800 $ and 09-2017->09/2018 (renewal), 7500 $)
Supervision(s) : – Jerry Tang, Summer Internship, Harvard University – 2 months
09/2011 – 03/2016 Post-Doctoral Researcher – Institut Pasteur, BioImage Analysis Unit (P.I. Jean-Christophe Olivo-Marin), CNRS UMR 3691. Paris, France
Project: Statistical analysis of spatio-temporal processes in cell biology
Fellowships: Bourse Roux-Howard-Cantarini (09-2013->09/2015)
Supervision(s) :
– Marina Lopez-Yunta (6 Months) Master 2 Modélisation en Biologie (UPMC)
– Quentin Marcou (2 months) MD-PhD program, Université Paris Descartes
– Antoine Bardonnet (6 months) Final engineering internship,ENSIMAG
– Laetitia Dufour (2 months) Summer Internship Master 1, UPMC
– Anna Damato (2 months) Summer Internship program, Pasteur Foundation
– Thang Le (6 months) Final engineering internship, EURECOM.
09/2010 – 09/2011 Research Assistant – Institut de la Vision, Genetics Physiologiy of Hearing Unit (P.I. Christine Petit) INSERM U587. Paris, France.
Project: Stochastic modeling of pre-synaptic vesicles dynamics and recycling
09/2009 – 09/2011 Temporary teacher and researcher ( A.T.E.R) – Université Paris Diderot, Laboratoire de Probabilités et Modèles Aléatoires CNRS 7599, Paris, France (Dir. Gilles Pagès).
09/2006 – 09/2009 Instructor -Université Paris Diderot. Paris, France.
09/2006 – 09/2009 PhD Student – Institut de Biologie de l’ENS (IBENS) – CNRS UMR8197, Inserm U1024. Team “Theoretical Modeling of Cellular Physiology” (P.I. David Holcman) Paris, France.
PhD title: Stochastic modeling of early steps of viral infection
Fellowships: Excellence Fellowship from Government of France-Ministry of Higher Education and Research
08/2004 – 08/2005 Quantitative Analyst – Crédit Agricole, Groupe de Recherche Opérationnel. Paris, France.
Activity: Audit of stochastic models and their implementation for the pricing of exotic financial products
A.2 Prizes
• Best oral presentation at the Exocytosis-Endocytosis annual meeting (2014)
• Fellowship to attend the French bi-annual congress of applied mathematics (SMAI) (2013)
• Poster Prize (3rd) at the Young Researcher in Life Sciences Conference (2012)
A.3 Teaching
• 2015 : INSERM, France. Colocalization in Image Analysis, Icy Formation level 2
• 2014 : CNRS, France. Colocalization in Image Analysis, ANR Correlation in Image Analysis
• 2014 : Institut Pasteur Paris, France. Colocalization in Image Analysis, Molecular Biology of the Cell Course
• 2009-2011 : Université Paris Diderot. Paris, France. « A.T.E.R. » Algebra and Analysis (L1 level, 2009-2010), Statistics (L1 level, 2010-2011).
• 2006-2009 : Université Paris Diderot. Paris, France, « Moniteur » Probabilities and Scilab programming (L3 level)
A.4 Pair-Reviewing
• PLoS Computational Biology (2019-)
• Transaction in Image Processing (2017-)
• Biophysical Journal (2016-)
• Frontiers in Microbiology (2016-)
• Journal of Biological Physics (2016-)
• PLoS One (2015-)
C. Congress communications
C.1 Selected oral communications
• Society for Neurosciences (SfN) Annual Meeting Nanosymposium Talk “Modeling the nano-physiology of dendritic spines with electro-diffusion” (Washington DC, USA) 2017
• UPENN Math-bio seminar Invited Talk “Spatial Statistics in Bioimage Analysis” (UPENN Philadelphia, USA) 2015
• ASCB Annual Meeting Microsymposium Talk “Analyzing the spatial colocalization of synaptic molecules with SIM and spatial statistics” (San Diego, USA) 2015
• Quantitative BioImaging Conference Contributed Talk “Analysis of the spatial organization of molecules with robust statistics” (Paris, France) 2015
• Workshop on Image-based Systems Biology, Invited Talk “Colocalization analysis of biomolecules” (Jena, Germany) 2015
• Workshop on spatial statistics Invited Talk “Analysis of the spatial organization of molecules with robust statistics” (Paris-Sup University, France) 2014
• Annual Meeting of the Club Exocytose-Endocytose Selected Talk “A statistical framework to analyze colocalization in bioimaging” (Pornichet, France) 2014
• Asilomar Conference- Selected Talk “Analysis of spatial clustering with robust statistics” (Pacific Grove, CA, U.S.A.) 2013
• SMAI bi-annual meeting- Selected Talk “Testing spatial clustering with fast and robust analytical statistics” (Seignosse le Penon, France) 2013
• ICIAM bi-annual meeting – Minisymposium “Modeling and Tracking Molecules: Signal Transduction, Aggregates” (Vancouver, Canada) 2011
• Gordon-Kenan Research Seminar (Physical Virology) – Selected Talk “Modeling the endosomal step of viral infection – Influenza as an example of enveloped viruses” (Ventura, U.S.A.) 2011
• Synthetic Biology in Pharma Conference – Invited Talk “Modeling the endosomal step of viral infection” (Cambridge, U.K.) 2010
• SIAM Conference on Dynamical Systems – Minisymposium “Molecular Diffusion and Transport in Cells” (Salt Lake City, U.S.A.) 2010
• SIAM Annual Meeting- Selected Talk “Quantifying intermittent transport in cell cytoplasm” (San Diego, U.S.A.) 2008
C.2 Patents
Agence pour la Protection des Programmes (APP): SODA: Statistical analysis of single molecule coupling with STORM imaging and spatial statistics
Thibault Lagache (50%), Lydia Danglot (25%) and Jean-Christophe Olivo-Marin (25%)