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© Research

Courses

Webinar sur les méthodes de colocalisation avancées (SODA) pour la NEUBIAS Academy

In this webinar from the NEUBIAS Academy @Home series, we will first present advanced colocalization methods for analyzing SMLM data, before introducing statistical tools for analyzing the spatial distribution of objects.Part1: By generating point […]

2020-10-14 14:00:00 2020-10-14 18:00:00 Europe/Paris Webinar sur les méthodes de colocalisation avancées (SODA) pour la NEUBIAS Academy In this webinar from the NEUBIAS Academy @Home series, we will first present advanced colocalization methods for analyzing SMLM data, before introducing statistical tools for analyzing the spatial distribution of objects.Part1: By generating point […] Pasteur Institute, Rue du Docteur Roux, Paris, France

Projects

CV

Thibault Lagache (PhD)

Permanent Researcher

  • Institut Pasteur – Department of Cell Biology & Infection – BioImage Analysis Unit 25-28 rue du Docteur Roux, 75015 Paris  – +33 (0)7 66 03 75 65
  • thibault.lagache@pasteur.fr – thibault.lagache76@gmail.com

EDUCATION

  • Lycée Corneille, Rouen, France – Classes Préparatoires (2000-2002) – Mathematics & Physics (MPSI/MP*)
  • Ecole des Ponts ParisTech, France – Engineering Degree (2006) – Applied Mathematics & Computer Sciences
  • UPMC Paris 6 – Master 2 (2006) – Numerical Analysis (Highest honors, rank 2/71)
  • UPMC Paris 6 – PhD (2009) – Applied Mathematics (Highest honors)

A.1 Professional experiences.

  • Since 07/2019: Permanent researcher – Institut Pasteur, Department of Cell Biology and Infection, BioImage Analysis Unit – CNRS UMR 3691. Paris, France
  • 09/2016-06/2019 : Post-Doctoral Fellow – Columbia University, Department of Biological Sciences (P.I. Rafael Yuste) New-York, United States. Fellowships: Fondation Pour la Recherche Médicale (09-2016->09/2017, 30,000 €),Philippe Foundation (09-2016->09/2017, 7800 $ and 09-2017->09/2018 (renewal), 7500 $)
  • 09/2011 – 03/2016 Post-Doctoral Researcher – Institut Pasteur, BioImage Analysis Unit (P.I. Jean-Christophe Olivo-Marin), CNRS UMR 3691. Paris, France Fellowships: Bourse Roux-Howard-Cantarini (09-2013->09/2015)
  • 09/2010 – 09/2011 Research Assistant – Institut de la Vision, Genetics Physiologiy of Hearing Unit (P.I. Christine Petit) INSERM U587. Paris, France.
  • 09/2009 – 09/2011 Temporary teacher and researcher ( A.T.E.R) – Université Paris Diderot, Laboratoire de Probabilités et Modèles Aléatoires CNRS 7599, Paris, France (Dir. Gilles Pagès).
  • 09/2006 – 09/2009 Instructor -Université Paris Diderot. Paris, France.
  • 09/2006 – 09/2009 PhD Student – Institut de Biologie de l’ENS (IBENS) – CNRS UMR8197, Inserm U1024. Team “Theoretical Modeling of Cellular Physiology” (P.I. David Holcman) Paris, France. PhD title: Stochastic modeling of early steps of viral infection Fellowships: Excellence Fellowship from Government of France-Ministry of Higher Education and Research
  • 08/2004 – 08/2005 Quantitative Analyst  – Crédit Agricole, Groupe de Recherche Opérationnel. Paris, France. Activity: Audit of stochastic models and their implementation for the pricing of exotic financial products

A.2 Grants

  • ANR PRCI (P.I) in collaboration with Rafael Yuste (Columbia University) (2022-2025, 240,000 euros) – REBIRTH: Understanding the self-assembly of the nervous system of Hydra vulgaris
  • ANR PRC (collaborator, P.I. Anne Brelot) (2021-2025, 53,000 euros) – GET-REDI: TarGETing CCR2 and CCR5 chemokine REceptors DImers: towards a better regulation of inflammation

A.3 Student Supervision

PhD Students

  • Samuel Kubler (2019-)

Master Students

  • Corentin Vannier, INSA Lyon
  • Victor Piriou, Sorbonne Université
  • Catalina Gonzales, Summer Internship program, Pasteur Foundation
  • Marina Lopez-Yunta, Sorbonne Université
  • Quentin Marcou, Université de Paris
  • Antoine Bardonnet, ENSIMAG Grenoble
  • Laetitia Dufour, Sorbonne Université
  • Anna Damato, Summer Internship program, Pasteur Foundation
  • Thang Le, EURECOM Sophia-Antipolis.

A.4 Editorial board & Peer-reviewing

Associate Editor at Biological Imaging (Cambridge University Press)

Peer-reviewing

  • PLoS Computational Biology (2019-)
  • Transaction in Image Processing (2017-)
  • Biophysical Journal (2016-)
  • Frontiers in Microbiology (2016-)
  • Journal of Biological Physics (2016-)
  • PLoS One (2015-)

A.4 Teaching

  •  2015 : INSERM, France. Colocalization in Image Analysis, Icy Formation level 2
  • 2014 : CNRS, France. Colocalization in Image Analysis, ANR Correlation in Image Analysis
  • 2014 : Institut Pasteur Paris, France. Colocalization in Image Analysis, Molecular Biology of the Cell Course
  • 2009-2011 : Université Paris Diderot. Paris, France. « A.T.E.R. » Algebra and Analysis (L1 level, 2009-2010), Statistics (L1 level, 2010-2011).
  • 2006-2009 : Université Paris Diderot. Paris, France, « Moniteur » Probabilities and Scilab programming (L3 level)

C.1 Selected oral communications

  • Society for Neurosciences (SfN) Annual Meeting Nanosymposium Talk “Modeling the nano-physiology of dendritic spines with electro-diffusion” (Washington DC, USA) 2017
  • UPENN Math-bio seminar Invited Talk “Spatial Statistics in Bioimage Analysis” (UPENN Philadelphia, USA) 2015
  • ASCB Annual Meeting Microsymposium Talk “Analyzing the spatial colocalization of synaptic molecules with SIM and spatial statistics” (San Diego, USA) 2015
  • Quantitative BioImaging Conference Contributed Talk “Analysis of the spatial organization of molecules with robust statistics” (Paris, France) 2015
  • Workshop on Image-based Systems Biology, Invited Talk “Colocalization analysis of biomolecules” (Jena, Germany) 2015
  • Workshop on spatial statistics Invited Talk “Analysis of the spatial organization of molecules with robust statistics” (Paris-Sup University, France) 2014
  • Annual Meeting of the Club Exocytose-Endocytose Selected Talk “A statistical framework to analyze colocalization in bioimaging” (Pornichet, France) 2014
  • Asilomar Conference- Selected Talk “Analysis of spatial clustering with robust statistics” (Pacific Grove, CA, U.S.A.) 2013
  • SMAI bi-annual meeting- Selected Talk “Testing spatial clustering with fast and robust analytical statistics” (Seignosse le Penon, France) 2013
  • ICIAM bi-annual meeting – Minisymposium “Modeling and Tracking Molecules: Signal Transduction, Aggregates” (Vancouver, Canada) 2011
  • Gordon-Kenan Research Seminar (Physical Virology) – Selected Talk “Modeling the endosomal step of viral infection – Influenza as an example of enveloped viruses” (Ventura, U.S.A.) 2011
  • Synthetic Biology in Pharma Conference – Invited Talk “Modeling the endosomal step of viral infection” (Cambridge, U.K.) 2010
  • SIAM Conference on Dynamical Systems – Minisymposium “Molecular Diffusion and Transport in Cells” (Salt Lake City, U.S.A.) 2010
  • SIAM Annual Meeting- Selected Talk “Quantifying intermittent transport in cell cytoplasm” (San Diego, U.S.A.) 2008

Publications

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