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CV

Thibault Lagache (PhD)

Permanent Researcher

Institut Pasteur – Department of Cell Biology & Infection – BioImage Analysis Unit

25-28 rue du Docteur Roux, 75015 Paris  – +33 (0)7 66 03 75 65

thibault.lagache@pasteur.fr – thibault.lagache76@gmail.com

EDUCATION

Lycée Jehan-Ango, Dieppe, France  – Baccalaureate  (2000) – Scientific section (Highest honors)

Lycée Corneille, Rouen, France – Classes Préparatoires (2000-2002) – Mathematics & Physics (MPSI/MP*)

Ecole des Ponts ParisTech, France – Engineering Degree (2006) – Applied Mathematics & Computer Sciences

UPMC Paris 6 – Master 2 (2006) – Numerical Analysis (Highest honors, rank 2/71)

UPMC Paris 6 – PhD (2009) – Applied Mathematics (Highest honors)

A.1 Professional experiences.

Since 07/2019: Permanent researcher – Institut Pasteur, Department of Cell Biology and Infection, BioImage Analysis Unit – CNRS UMR 3691. Paris, France

09/2016-06/2019 : Post-Doctoral Fellow – Columbia University, Department of Biological Sciences (P.I. Rafael Yuste) New-York, United States.

Project: Nanophysiology of synaptic transmission

Fellowships: Fondation Pour la Recherche Médicale (09-2016->09/2017, 30,000 €),Philippe Foundation (09-2016->09/2017, 7800 $ and 09-2017->09/2018 (renewal), 7500 $)

Supervision(s) : – Jerry Tang, Summer Internship, Harvard University – 2 months

09/2011 – 03/2016 Post-Doctoral Researcher – Institut Pasteur, BioImage Analysis Unit (P.I. Jean-Christophe Olivo-Marin), CNRS UMR 3691. Paris, France

Project: Statistical analysis of spatio-temporal processes in cell biology

Fellowships: Bourse Roux-Howard-Cantarini (09-2013->09/2015)

Supervision(s) :

– Marina Lopez-Yunta (6 Months) Master 2 Modélisation en Biologie (UPMC)

– Quentin Marcou (2 months) MD-PhD program, Université Paris Descartes

– Antoine Bardonnet (6 months) Final engineering internship,ENSIMAG

– Laetitia Dufour (2 months) Summer Internship Master 1, UPMC

– Anna Damato (2 months) Summer Internship program, Pasteur Foundation

– Thang Le (6 months) Final engineering internship, EURECOM.

09/2010 – 09/2011 Research Assistant – Institut de la Vision, Genetics Physiologiy of Hearing Unit (P.I. Christine Petit) INSERM U587. Paris, France.

Project: Stochastic modeling of pre-synaptic vesicles dynamics and recycling

09/2009 – 09/2011 Temporary teacher and researcher ( A.T.E.R) – Université Paris Diderot, Laboratoire de Probabilités et Modèles Aléatoires CNRS 7599, Paris, France (Dir. Gilles Pagès).

09/2006 – 09/2009 Instructor -Université Paris Diderot. Paris, France.

09/2006 – 09/2009 PhD Student – Institut de Biologie de l’ENS (IBENS) – CNRS UMR8197, Inserm U1024. Team “Theoretical Modeling of Cellular Physiology” (P.I. David Holcman) Paris, France.

PhD title: Stochastic modeling of early steps of viral infection

Fellowships: Excellence Fellowship from Government of France-Ministry of Higher Education and Research

08/2004 – 08/2005 Quantitative Analyst  – Crédit Agricole, Groupe de Recherche Opérationnel. Paris, France.

Activity: Audit of stochastic models and their implementation for the pricing of exotic financial products

A.2 Prizes

• Best oral presentation at the Exocytosis-Endocytosis annual meeting (2014)

• Fellowship to attend the French bi-annual congress of applied mathematics (SMAI) (2013)

• Poster Prize (3rd) at the Young Researcher in Life Sciences Conference (2012)

A.3 Teaching

  2015 : INSERM, France. Colocalization in Image Analysis, Icy Formation level 2

  2014 : CNRS, France. Colocalization in Image Analysis, ANR Correlation in Image Analysis

  2014 : Institut Pasteur Paris, France. Colocalization in Image Analysis, Molecular Biology of the Cell Course

  2009-2011 : Université Paris Diderot. Paris, France. « A.T.E.R. » Algebra and Analysis (L1 level, 2009-2010), Statistics (L1 level, 2010-2011).

  2006-2009 : Université Paris Diderot. Paris, France, « Moniteur » Probabilities and Scilab programming (L3 level)

A.4 Pair-Reviewing

• PLoS Computational Biology (2019-)

• Transaction in Image Processing (2017-)

• Biophysical Journal (2016-)

• Frontiers in Microbiology (2016-)

• Journal of Biological Physics (2016-)

• PLoS One (2015-)

C. Congress communications

C.1 Selected oral communications

Society for Neurosciences (SfN) Annual Meeting Nanosymposium Talk “Modeling the nano-physiology of dendritic spines with electro-diffusion” (Washington DC, USA) 2017

UPENN Math-bio seminar Invited Talk “Spatial Statistics in Bioimage Analysis” (UPENN Philadelphia, USA) 2015

ASCB Annual Meeting Microsymposium Talk “Analyzing the spatial colocalization of synaptic molecules with SIM and spatial statistics” (San Diego, USA) 2015

Quantitative BioImaging Conference Contributed Talk “Analysis of the spatial organization of molecules with robust statistics” (Paris, France) 2015

Workshop on Image-based Systems Biology, Invited Talk “Colocalization analysis of biomolecules” (Jena, Germany) 2015

Workshop on spatial statistics Invited Talk “Analysis of the spatial organization of molecules with robust statistics” (Paris-Sup University, France) 2014

Annual Meeting of the Club Exocytose-Endocytose Selected Talk “A statistical framework to analyze colocalization in bioimaging” (Pornichet, France) 2014

Asilomar Conference- Selected Talk “Analysis of spatial clustering with robust statistics” (Pacific Grove, CA, U.S.A.) 2013

SMAI bi-annual meeting- Selected Talk “Testing spatial clustering with fast and robust analytical statistics” (Seignosse le Penon, France) 2013

ICIAM bi-annual meeting – Minisymposium “Modeling and Tracking Molecules: Signal Transduction, Aggregates” (Vancouver, Canada) 2011

Gordon-Kenan Research Seminar (Physical Virology) – Selected Talk “Modeling the endosomal step of viral infection – Influenza as an example of enveloped viruses” (Ventura, U.S.A.) 2011

Synthetic Biology in Pharma Conference – Invited Talk “Modeling the endosomal step of viral infection” (Cambridge, U.K.) 2010

SIAM Conference on Dynamical Systems – Minisymposium “Molecular Diffusion and Transport in Cells” (Salt Lake City, U.S.A.) 2010

• SIAM Annual Meeting- Selected Talk “Quantifying intermittent transport in cell cytoplasm” (San Diego, U.S.A.) 2008

C.2 Patents

Agence pour la Protection des Programmes (APP): SODA: Statistical analysis of single molecule coupling with STORM imaging and spatial statistics

Thibault Lagache (50%), Lydia Danglot (25%) and Jean-Christophe Olivo-Marin (25%)

Publications

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