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© Therese Couderc, Marc Lecuit
Publication : Journal of the Pediatric Infectious Diseases Society

Next-Generation Sequencing for Diagnosis and Tailored Therapy: A Case Report of Astrovirus-Associated Progressive Encephalitis

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of the Pediatric Infectious Diseases Society - 12 Jul 2015

Frémond ML, Pérot P, Muth E, Cros G, Dumarest M, Mahlaoui N, Seilhean D, Desguerre I, Hébert C, Corre-Catelin N, Neven B, Lecuit M, Blanche S, Picard C, Eloit M

Link to Pubmed [PMID] – 26407445

J Pediatric Infect Dis Soc 2015 Sep;4(3):e53-7

A boy with X-linked agammaglobulinemia experienced progressive global motor decline, cerebellar syndrome, and epilepsy. All standard polymerase chain reactions for neurotropic viruses were negative on cerebrospinal fluid and brain biopsy. Next-generation sequencing allowed fast identification of a new astrovirus strain (HAstV-VA1/HMO-C-PA), which led to tailor the patient’s treatment, with encouraging clinical monitoring over 1 year.

https://www.ncbi.nlm.nih.gov/pubmed/26407445