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© Aline Bonnet, Institut Pasteur
Coupe transversale d’embryon de caille transgénique mbGFP à 18somites, au niveau du futur bourgeon de membre antérieur avec un marquage noyaux (bleu), GFP (vert) et actine (rouge) / Transversal section of a mbGFP transgenic quail embryo at 18-somite stage, at forelimb level, with nuclei (blue), GFP (green) and actin (red) labelling
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Developmental cell - 11 Apr 2022

Parada C, Banavar SP, Khalilian P, Rigaud S, Michaut A, Liu Y, Joshy DM, Campàs O, Gros J,

Link to Pubmed [PMID] – 35413235

Link to DOI – 10.1016/j.devcel.2022.03.004

Dev Cell 2022 Apr; 57(7): 854-866.e6

During embryonic development, digits gradually emerge in a periodic pattern. Although genetic evidence indicates that digit formation results from a self-organizing process, the underlying mechanisms are still unclear. Here, we find that convergent-extension tissue flows driven by active stresses underlie digit formation. These active stresses simultaneously shape cartilage condensations and lead to the emergence of a compressive stress region that promotes high activin/p-SMAD/SOX9 expression, thereby defining digit-organizing centers via a mechanical feedback. In Wnt5a mutants, such mechanical feedback is disrupted due to the loss of active stresses, organizing centers do not emerge, and digit formation is precluded. Thus, digit emergence does not result solely from molecular interactions, as was previously thought, but requires a mechanical feedback that ensures continuous coupling between phalanx specification and elongation. Our work, which links mechanical and molecular signals, provides a mechanistic context for the emergence of organizing centers that may underlie various developmental processes.

https://pubmed.ncbi.nlm.nih.gov/35413235