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© Research
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Science - 21 May 2015

Eberl G, Colonna M, Di Santo JP, McKenzie AN

Link to Pubmed [PMID] – 25999512

Science 2015 May;348(6237):aaa6566

Innate lymphoid cells (ILCs) are a growing family of immune cells that mirror the phenotypes and functions of T cells. However, in contrast to T cells, ILCs do not express acquired antigen receptors or undergo clonal selection and expansion when stimulated. Instead, ILCs react promptly to signals from infected or injured tissues and produce an array of secreted proteins termed cytokines that direct the developing immune response into one that is adapted to the original insult. The complex cross-talk between microenvironment, ILCs, and adaptive immunity remains to be fully deciphered. Only by understanding these complex regulatory networks can the power of ILCs be controlled or unleashed in order to regulate or enhance immune responses in disease prevention and therapy.

http://www.ncbi.nlm.nih.gov/pubmed/25999512