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© Pierre Gounon
Entrée de Listeria dans une cellule épithéliale (Grossissement X 10000). Image colorisée.
Publication : Current protocols in microbiology

Animal models of Listeria infection

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Current protocols in microbiology - 01 Aug 2008

Cabanes D, Lecuit M, Cossart P

Link to Pubmed [PMID] – 18729060

Curr Protoc Microbiol 2008 Aug;Chapter 9:Unit9B.1

Listeria monocytogenes is an intracellular foodborne pathogen that causes listeriosis, an infection characterized by gastroenteritis, meningitis, encephalitis, and maternofetal infections in humans. L. monocytogenes enters the host via contaminated foods, invades the small intestine, translocates to mesenteric lymph nodes, and spreads to the liver, spleen, brain and, in pregnant women, the fetoplacental unit. Many pathogenicity tests for studying L. monocytogenes have been developed, including tests using laboratory animals. A number of small animal species can be experimentally infected with Listeria. Mice and guinea pigs can be infected either intragastrically or intravenously, and virulence evaluated either by enumerating bacteria within infected target organs or by evaluating the 50% lethal dose (LD50). Although mice and guinea pigs can be infected with Listeria by a variety of routes, the intragastric route is the most relevant to the human foodborne listeriosis.

http://www.ncbi.nlm.nih.gov/pubmed/18729060