• 2023
  Ségolène Gracias, Maxime Chazal, Alice Decombe, Yves Unterfinger, Adrià Sogues, Lauryne Pruvost, Valentine Robert, Sandrine Lacour, Manon Lemasson, Marion Sourisseau, Zhi Li, Jennifer Richardson, Sandra Pellegrini, Etienne Decroly, Vincent Caval, Nolwenn Jouvenet, Tick-borne flavivirus NS5 antagonizes interferon signaling by inhibiting the catalytic activity of TYK2., EMBO Reports, In press, pp.e57424. ⟨10.15252/embr.202357424⟩.
• 2022
  Vuillier F, Li Z, Black I, Cruciani M, Rubino E, Michel F, Pellegrini S, , IFN-I inducible miR-3614-5p targets ADAR1 isoforms and fine tunes innate immune activation., Front Immunol 2022 ; 13(): 939907.
• 2021
  Bastard P, Manry J, Chen J, Rosain J, Seeleuthner Y, AbuZaitun O, Lorenzo L, Khan T, Hasek M, Hernandez N, Bigio B, Zhang P, Lévy R, Shrot S, Reino EJG, Lee YS, Boucherit S, Aubart M, Gijsbers R, Béziat V, Li Z, Pellegrini S, Rozenberg F, Marr N, Meyts I, Boisson B, Cobat A, Bustamante J, Zhang Q, Jouangy E, Abel L, Somech R, Casanova JL, Zhang SY, , Herpes simplex encephalitis in a patient with a distinctive form of inherited IFNAR1 deficiency., J Clin Invest 2021 Jan; 131(1): .
• 2021
  Devi-Marulkar P, Moraes-Cabe C, Campagne P, Corre B, Meghraoui-Kheddar A, Bondet V, Llibre A, Duffy D, Maillart E, Papeix C, Pellegrini S, Michel F, , Altered Immune Phenotypes and HLA-DQB1 Gene Variation in Multiple Sclerosis Patients Failing Interferon β Treatment., Front Immunol 2021 ; 12(): 628375.
• 2020
  Pellegrini S, Uzé G, , An Old Cytokine Against a New Virus?, J Interferon Cytokine Res 2020 08; 40(8): 425-428.
• 2020
  Di Marco T, Bianchi F, Sfondrini L, Todoerti K, Bongarzone I, Maffioli EM, Tedeschi G, Mazzoni M, Pagliardini S, Pellegrini S, Neri A, Anania MC, Greco A, , COPZ1 depletion in thyroid tumor cells triggers type I IFN response and immunogenic cell death., Cancer Lett 2020 04; 476(): 106-119.
• 2020
  Li Z, Rotival M, Patin E, Michel F, Pellegrini S, , Two common disease-associated TYK2 variants impact exon splicing and TYK2 dosage., PLoS One 2020 ; 15(1): e0225289.
• 2020
  Rubino E, Cruciani M, Tchitchek N, Le Tortorec A, Rolland AD, Veli Ö, Vallet L, Gaggi G, Michel F, Dejucq-Rainsford N, Pellegrini S, , Human Ubiquitin-Specific Peptidase 18 Is Regulated by microRNAs via the 3’Untranslated Region, A Sequence Duplicated in Long Intergenic Non-coding RNA Genes Residing in chr22q11.21., Front Genet 2020 ; 11(): 627007.
• 2019
  Vuillier F, Li Z, Commere PH, Dynesen LT, Pellegrini S, USP18 and ISG15 coordinately impact on SKP2 and cell cycle progression, Sci Rep 2019 Mar;9(1):4066.
• 2018
  Boisson-Dupuis S, Ramirez-Alejo N, Li Z, Patin E, Rao G, Kerner G, Lim CK, Krementsov DN, Hernandez N, Ma CS, Zhang Q, Markle J, Martinez-Barricarte R, Payne K, Fisch R, Deswarte C, Halpern J, Bouaziz M, Mulwa J, Sivanesan D, Lazarov T, Naves R, Garcia P, Itan Y, Boisson B, Checchi A, Jabot-Hanin F, Cobat A, Guennoun A, Jackson CC, Pekcan S, Caliskaner Z, Inostroza J, Costa-Carvalho BT, de Albuquerque JAT, Garcia-Ortiz H, Orozco L, Ozcelik T, Abid A, Rhorfi IA, Souhi H, Amrani HN, Zegmout A, Geissmann F, Michnick SW, Muller-Fleckenstein I, Fleckenstein B, Puel A, Ciancanelli MJ, Marr N, Abolhassani H, Balcells ME, Condino-Neto A, Strickler A, Abarca K, Teuscher C, Ochs HD, Reisli I, Sayar EH, El-Baghdadi J, Bustamante J, Hammarström L, Tangye SG, Pellegrini S, Quintana-Murci L, Abel L, Casanova JL, Tuberculosis and impaired IL-23-dependent IFN-γ immunity in humans homozygous for a common missense variant, Sci Immunol 2018 Dec;3(30).
• 2018
  Charbit-Henrion F, Bègue B, Sierra A, Hanein S, Stolzenberg MC, Li Z, Pellegrini S, Garcelon N, Jeanpierre M, Neven B, Loge I, Picard C, Rosain J, Bustamante J, Le Lorc'h M, Pigneur B, Fernandes A, , Rieux-Laucat F, Amil Dias J, Ruemmele FM, Cerf-Bensussan N, Copy number variations and founder effect underlying complete IL-10Rβ deficiency in Portuguese kindreds, PLoS ONE 2018;13(10):e0205826.
• 2017
  Govender U, Corre B, Bourdache Y, Pellegrini S, Michel F, Type I interferon-enhanced IL-10 expression in human CD4 T cells is regulated by STAT3, STAT2, and BATF transcription factors, J. Leukoc. Biol. 2017 05;101(5):1181-1190.
• 2017
  Arimoto KI, Löchte S, Stoner SA, Burkart C, Zhang Y, Miyauchi S, Wilmes S, Fan JB, Heinisch JJ, Li Z, Yan M, Pellegrini S, Colland F, Piehler J, Zhang DE, STAT2 is an essential adaptor in USP18-mediated suppression of type I interferon signaling, Nat. Struct. Mol. Biol. 2017 Mar;24(3):279-289.
• 2016
  Baron L, Paatero AO, Morel JD, Impens F, Guenin-Macé L, Saint-Auret S, Blanchard N, Dillmann R, Niang F, Pellegrini S, Taunton J, Paavilainen VO, Demangel C, , Mycolactone subverts immunity by selectively blocking the Sec61 translocon., J Exp Med 2016 12; 213(13): 2885-2896.
• 2016
  Meuwissen ME, Schot R, Buta S, Oudesluijs G, Tinschert S, Speer SD, Li Z, van Unen L, Heijsman D, Goldmann T, Lequin MH, Kros JM, Stam W, Hermann M, Willemsen R, Brouwer RW, Van IJcken WF, Martin-Fernandez M, de Coo I, Dudink J, de Vries FA, Bertoli Avella A, Prinz M, Crow YJ, Verheijen FW, Pellegrini S, Bogunovic D, Mancini GM, Human USP18 deficiency underlies type 1 interferonopathy leading to severe pseudo-TORCH syndrome, J. Exp. Med. 2016 Jun;213(7):1163-74.
• 2016
  Speer SD, Li Z, Buta S, Payelle-Brogard B, Qian L, Vigant F, Rubino E, Gardner TJ, Wedeking T, Hermann M, Duehr J, Sanal O, Tezcan I, Mansouri N, Tabarsi P, Mansouri D, Francois-Newton V, Daussy CF, Rodriguez MR, Lenschow DJ, Freiberg AN, Tortorella D, Piehler J, Lee B, García-Sastre A, Pellegrini S, Bogunovic D, ISG15 deficiency and increased viral resistance in humans but not mice, Nat Commun 2016 05;7:11496.
• 2016
  Chaves-Ferreira M, Krenn G, Vasseur F, Barinov A, Gonçalves P, Azogui O, Cumano A, Li Z, Pellegrini S, Rocha B, Laderach D, The cyclin D1 carboxyl regulatory domain controls the division and differentiation of hematopoietic cells, Biol. Direct 2016;11:21.
• 2015
  Livingstone M, Sikström K, Robert PA, Uzé G, Larsson O, Pellegrini S, Assessment of mTOR-Dependent Translational Regulation of Interferon Stimulated Genes, PLoS ONE 2015;10(7):e0133482.
• 2015
  Wilmes S, Beutel O, Li Z, Francois-Newton V, Richter CP, Janning D, Kroll C, Hanhart P, Hötte K, You C, Uzé G, Pellegrini S, Piehler J, Receptor dimerization dynamics as a regulatory valve for plasticity of type I interferon signaling, J. Cell Biol. 2015 May;209(4):579-93.
• 2015
  Paul F, Pellegrini S, Uzé G, IFNA2: The prototypic human alpha interferon, Gene 2015 Aug;567(2):132-137.
• 2014
  Zhang X, Bogunovic D, Payelle-Brogard B, Francois-Newton V, Speer SD, Yuan C, Volpi S, Li Z, Sanal O, Mansouri D, Tezcan I, Rice GI, Chen C, Mansouri N, Mahdaviani SA, Itan Y, Boisson B, Okada S, Zeng L, Wang X, Jiang H, Liu W, Han T, Liu D, Ma T, Wang B, Liu M, Liu JY, Wang QK, Yalnizoglu D, Radoshevich L, Uzé G, Gros P, Rozenberg F, Zhang SY, Jouanguy E, Bustamante J, García-Sastre A, Abel L, Lebon P, Notarangelo LD, Crow YJ, Boisson-Dupuis S, Casanova JL, Pellegrini S, Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation, Nature 2015 Jan;517(7532):89-93.
• 2013
  Corre B, Perrier J, El Khouri M, Cerboni S, Pellegrini S, Michel F, Type I interferon potentiates T-cell receptor mediated induction of IL-10-producing CD4⁺ T cells, Eur. J. Immunol. 2013 Oct;43(10):2730-40.
• 2012
  Derecka M, Gornicka A, Koralov SB, Szczepanek K, Morgan M, Raje V, Sisler J, Zhang Q, Otero D, Cichy J, Rajewsky K, Shimoda K, Poli V, Strobl B, Pellegrini S, Harris TE, Seale P, Russell AP, McAinch AJ, O'Brien PE, Keller SR, Croniger CM, Kordula T, Larner AC, Tyk2 and Stat3 regulate brown adipose tissue differentiation and obesity, Cell Metab. 2012 Dec;16(6):814-24.
• 2012
  Francois-Newton V, Livingstone M, Payelle-Brogard B, Uzé G, Pellegrini S, USP18 establishes the transcriptional and anti-proliferative interferon α/β differential, Biochem. J. 2012 Sep;446(3):509-16.
• 2012
  Cho IR, Oh M, Koh SS, Malilas W, Srisuttee R, Jhun BH, Pellegrini S, Fuchs SY, Chung YH, Hepatitis B virus X protein inhibits extracellular IFN-α-mediated signal transduction by downregulation of type I IFN receptor, Int. J. Mol. Med. 2012 Apr;29(4):581-6.
• 2011
  Velazquez L, Fellous M, Stark GR, Pellegrini S, Pillars article: A protein tyrosine kinase in the interferon α/β signaling pathway. Cell. 1992. 70: 313-322, J. Immunol. 2011 Dec;187(11):5479-88.
• 2011
  François-Newton V, Magno de Freitas Almeida G, Payelle-Brogard B, Monneron D, Pichard-Garcia L, Piehler J, Pellegrini S, Uzé G, USP18-based negative feedback control is induced by type I and type III interferons and specifically inactivates interferon α response, PLoS ONE 2011;6(7):e22200.
• 2011
  Ben-Ali M, Corre B, Manry J, Barreiro LB, Quach H, Boniotto M, Pellegrini S, Quintana-Murci L, Functional characterization of naturally occurring genetic variants in the human TLR1-2-6 gene family, Hum. Mutat. 2011 Jun;32(6):643-52.
• 2010
  Dong S, Corre B, Nika K, Pellegrini S, Michel F, T cell receptor signal initiation induced by low-grade stimulation requires the cooperation of LAT in human T cells, PLoS ONE 2010;5(11):e15114.
• 2010
  Boselli D, Ragimbeau J, Orlando L, Cappello P, Capello M, Ambrogio C, Chiarle R, Marsili G, Battistini A, Giovarelli M, Pellegrini S, Novelli F, Expression of IFNγR2 mutated in a dileucine internalization motif reinstates IFNγ signaling and apoptosis in human T lymphocytes, Immunol. Lett. 2010 Nov;134(1):17-25.
• 2010
  Payelle-Brogard B, Pellegrini S, Biochemical monitoring of the early endocytic traffic of the type I interferon receptor, J. Interferon Cytokine Res. 2010 Feb;30(2):89-98.
• 2009
  Barreiro LB, Ben-Ali M, Quach H, Laval G, Patin E, Pickrell JK, Bouchier C, Tichit M, Neyrolles O, Gicquel B, Kidd JR, Kidd KK, Alcaïs A, Ragimbeau J, Pellegrini S, Abel L, Casanova JL, Quintana-Murci L, Evolutionary dynamics of human Toll-like receptors and their different contributions to host defense, PLoS Genet. 2009 Jul;5(7):e1000562.
• 2009
  Moraga I, Harari D, Schreiber G, Uzé G, Pellegrini S, Receptor density is key to the alpha2/beta interferon differential activities, Mol. Cell. Biol. 2009 Sep;29(17):4778-87.
• 2008
  Libri V, Schulte D, van Stijn A, Ragimbeau J, Rogge L, Pellegrini S, Jakmip1 is expressed upon T cell differentiation and has an inhibitory function in cytotoxic T lymphocytes, J. Immunol. 2008 Nov;181(9):5847-56.
• 2008
  Kumar KG, Varghese B, Banerjee A, Baker DP, Constantinescu SN, Pellegrini S, Fuchs SY, Basal ubiquitin-independent internalization of interferon alpha receptor is prevented by Tyk2-mediated masking of a linear endocytic motif, J. Biol. Chem. 2008 Jul;283(27):18566-72.
• 2008
  Gakovic M, Ragimbeau J, Francois V, Constantinescu SN, Pellegrini S, The Stat3-activating Tyk2 V678F mutant does not up-regulate signaling through the type I interferon receptor but confers ligand hypersensitivity to a homodimeric receptor, J. Biol. Chem. 2008 Jul;283(27):18522-9.
• 2007
  Liu J, Plotnikov A, Banerjee A, Suresh Kumar KG, Ragimbeau J, Marijanovic Z, Baker DP, Pellegrini S, Fuchs SY, Ligand-independent pathway that controls stability of interferon alpha receptor, Biochem. Biophys. Res. Commun. 2008 Mar;367(2):388-93.
• 2007
  Marijanovic Z, Ragimbeau J, van der Heyden J, Uzé G, Pellegrini S, Comparable potency of IFNalpha2 and IFNbeta on immediate JAK/STAT activation but differential down-regulation of IFNAR2, Biochem. J. 2007 Oct;407(1):141-51.
• 2007
  Nishimura Y, Martin CL, Vazquez-Lopez A, Spence SJ, Alvarez-Retuerto AI, Sigman M, Steindler C, Pellegrini S, Schanen NC, Warren ST, Geschwind DH, Genome-wide expression profiling of lymphoblastoid cell lines distinguishes different forms of autism and reveals shared pathways, Hum. Mol. Genet. 2007 Jul;16(14):1682-98.
• 2006
  Remoli ME, Ragimbeau J, Giacomini E, Gafa V, Severa M, Lande R, Pellegrini S, Coccia EM, NF-{kappa}B is required for STAT-4 expression during dendritic cell maturation, J. Leukoc. Biol. 2007 Jan;81(1):355-63.
• 2006
  Longman RS, Braun D, Pellegrini S, Rice CM, Darnell RB, Albert ML, Dendritic-cell maturation alters intracellular signaling networks, enabling differential effects of IFN-alpha/beta on antigen cross-presentation, Blood 2007 Feb;109(3):1113-22.
• 2006
  Marijanovic Z, Ragimbeau J, Kumar KG, Fuchs SY, Pellegrini S, TYK2 activity promotes ligand-induced IFNAR1 proteolysis, Biochem. J. 2006 Jul;397(1):31-8.
• 2006
  Severa M, Remoli ME, Giacomini E, Ragimbeau J, Lande R, Uzé G, Pellegrini S, Coccia EM, Differential responsiveness to IFN-alpha and IFN-beta of human mature DC through modulation of IFNAR expression, J. Leukoc. Biol. 2006 Jun;79(6):1286-94.
• 2004
  Dondi E, Roué G, Yuste VJ, Susin SA, Pellegrini S, A dual role of IFN-alpha in the balance between proliferation and death of human CD4+ T lymphocytes during primary response, J. Immunol. 2004 Sep;173(6):3740-7.
• 2004
  Steindler C, Li Z, Algarté M, Alcover A, Libri V, Ragimbeau J, Pellegrini S, Jamip1 (marlin-1) defines a family of proteins interacting with janus kinases and microtubules, J. Biol. Chem. 2004 Oct;279(41):43168-77.
• 2003
  Shaw MH, Boyartchuk V, Wong S, Karaghiosoff M, Ragimbeau J, Pellegrini S, Muller M, Dietrich WF, Yap GS, A natural mutation in the Tyk2 pseudokinase domain underlies altered susceptibility of B10.Q/J mice to infection and autoimmunity, Proc. Natl. Acad. Sci. U.S.A. 2003 Sep;100(20):11594-9.
• 2003
  Ragimbeau J, Dondi E, Alcover A, Eid P, Uzé G, Pellegrini S, The tyrosine kinase Tyk2 controls IFNAR1 cell surface expression, EMBO J. 2003 Feb;22(3):537-47.
• 2003
  Dondi E, Rogge L, Lutfalla G, Uzé G, Pellegrini S, Down-modulation of responses to type I IFN upon T cell activation, J. Immunol. 2003 Jan;170(2):749-56.
• 2002
  Remoli ME, Giacomini E, Lutfalla G, Dondi E, Orefici G, Battistini A, Uzé G, Pellegrini S, Coccia EM, Selective expression of type I IFN genes in human dendritic cells infected with Mycobacterium tuberculosis, J. Immunol. 2002 Jul;169(1):366-74.