HDX-MS of membrane proteins
HDX (Hydrogen Deuterium Exchange) MS is a powerful tool to monitor conformational changes in proteins and to characterize protein-protein interactions. The Synapt G2-Si HDMS mass spectrometer used for HDX experiments is also equipped with […]
Cross-linking Mass Spectrometry
Covalent cross-linking combined to mass spectrometry is a powerful approach to address both the structure and composition of protein complexes. To improve the crucial stage of detection and characterization of cross-linked peptides, we have […]
ProteoCombiner is a high-performance software integrating shotgun with top-down proteomic data. The tool can deal with multiple experiments and search engines. It enables rapid and easy visualization, manual validation, and comparison of the identified […]
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2021De Novo Sequencing of Antibody Light Chain Proteoforms from Patients with Multiple Myeloma., Anal Chem 2021 08; 93(30): 10627-10634.
2021Advanced In Vivo Cross-Linking Mass Spectrometry Platform to Characterize Proteome-Wide Protein Interactions., Anal Chem 2021 Feb; (): .