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© Cédric Delevoye
Cellules infectÈes par Chlamydia trachomatis. Les bactÈries se dÈveloppent dans une vacuole (rouge), ‡ proximitÈ du noyau de la cellule-hÙte (bleu). Ce compartiment interagit de faÁon Ètroite avec ceux de la cellule hÙte. Marquage vert= localisation d'une protÈine de l'hÙte, Vamp8, exprimÈe par transfection. Les Chlamydia sont, selon les souches, responsables de maladies sexuellement transmises, de cÈcitÈs, d'infections pulmonaires et pourraient Ítre impliquÈes dans l'athÈrosclÈrose.
Scientific Fields
Diseases
Organisms
Applications
Technique
Starting Date
18
May 2015
Status
Ongoing
Members
4
Structures
1

About

The membrane of the inclusion is key for the regulation of the exchanges between the bacteria and the host. We study its biogenesis and how metabolites from the host are transported to the lumen of the inclusion.

Identification of type III secreted proteins and functional studies

Throughout their cycle in the host cell, chlamydiae remain in a compartment called an inclusion. They use a type III secretion mechanism to translocate proteins into the host cell. These proteins allow the bacteria to manipulate host activities to their benefit. By studying the function of these proteins we aim at understanding how the bacteria escape innate defense from the host and thrive in the vacuolar environment.

image008.jpg
Cells infected for 24 hrs with C. trachomatis. The cell nuclei are labelled in blue, the bacteria appear yellow, within the inclusion lumen. A bacterial protein secreted into the host cytoplasm is labelled in red.

Living on host resources

Chlamydiae uses host metabolites for growth. They lack enzymes for several biosynthetic pathways, and exploit their host to compensate. We study the mechanisms by which cytosolic metabolites reach the inclusion lumen, and the consequences of the infection on the metabolism of the host.