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Content 2
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Clinical Research Nurse
  • Clinician Researcher
  • Department Manager
  • Dual-education Student
  • Full Professor
  • Honorary Professor
  • Lab assistant
  • Master Student
  • Non-permanent Researcher
  • Nursing Staff
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Prize
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
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Scientific Fields
Diseases
Organisms
Applications
Technique
Starting Date
25
Oct 2018
Status
Ongoing
Members
3
Structures
3

About

HDX (Hydrogen Deuterium Exchange) MS is a powerful tool to monitor conformational changes in proteins and to characterize protein-protein interactions. The Synapt G2-Si HDMS mass spectrometer used for HDX experiments is also equipped with an HDX Manager (maintaining valves and columns at low temperature) and a LEAP-PAL robot for automated sample handling at high-throughput. Our lab has gained a strong expertise in the analysis of integral membrane proteins. As part of a collaboration with the group of Nicolas Reyes (Institut Pasteur, Paris), we are currently studying the conformation and dynamics of several integral membrane protein transporters considered as potential drug targets. HDX-MS can also be used for epitope mapping. For more information, contact martial.rey@pasteur.fr (responsible for the Synapt instrument and HDX-MS experiments).