Search anything and hit enter
  • Teams
  • Members
  • Projects
  • Events
  • Calls
  • Jobs
  • publications
  • Software
  • Tools
  • Network
  • Equipment

A little guide for advanced search:

  • Tip 1. You can use quotes "" to search for an exact expression.
    Example: "cell division"
  • Tip 2. You can use + symbol to restrict results containing all words.
    Example: +cell +stem
  • Tip 3. You can use + and - symbols to force inclusion or exclusion of specific words.
    Example: +cell -stem
e.g. searching for members in projects tagged cancer
Search for
Count
IN
OUT
Content 1
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Clinical Research Nurse
  • Clinician Researcher
  • Department Manager
  • Dual-education Student
  • Full Professor
  • Honorary Professor
  • Lab assistant
  • Master Student
  • Non-permanent Researcher
  • Nursing Staff
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Prize
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Content 2
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Clinical Research Nurse
  • Clinician Researcher
  • Department Manager
  • Dual-education Student
  • Full Professor
  • Honorary Professor
  • Lab assistant
  • Master Student
  • Non-permanent Researcher
  • Nursing Staff
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Prize
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Search

← Go to Research

Go back
Scroll to top
Share

Most cancer immunotherapies rely on the cytotoxic properties of CD8 T cells, overshadowing the potential activity of CD4⁺ T cells targeting cancer cells. In this new study published in Nature Cancer, the team led by Philippe Bousso focused on CD4⁺ CAR T cells and showed that they significantly contribute to tumor regression through the long-range apoptotic effect of interferon-γ (IFN-γ).

In a mouse model of B cell lymphoma, they used intravital imaging of the bone marrow to observe the mode of action of CD4⁺ CAR T cells. It appears that the majority of killing events occur without direct contact with a cancer cell but at distance, through the production of IFN-γ which diffuses in the tumor microenvironment. Using different cell lines, they then showed that tumor sensitivity to IFN-γ could be a key factor in explaining the variability of CD4⁺ CAR T cell efficacy between patients.

These results were confronted to clinical data from a cohort of 63 patients with diffuse large B-cell lymphoma treated with CAR T cells at Hôpital Saint-Louis (Paris). Patients with high CD4⁺:CD8⁺ CAR T cell ratio showed stronger induction of IFN-γ. Among these patients, higher serum levels of IFN-γ were associated with significantly improved progression-free and overall survival, highlighting the antitumor activity of the cytokine produced by CD4⁺ CAR T cells and the potential of IFN-γ tumor sensitivity as a key parameter for personalized used of CAR T cell immunotherapies.

Source

Tumor-intrinsic sensitivity to the pro-apoptotic effects of IFN-γ is a major determinant of CD4+ CAR T-cell antitumor activity, Nature Cancer, 29 mai 2023

Attack of a tumor by CAR T cells visualised using intravital imaging. Living cancer cells are shown in white, killed cancer cells in blue and CAR T cells in green. The white circles indicate the destruction of cancer cells during direct contact with CAR T cells, while the red circles indicate the destruction of cancer cells at a distance. © Morgane Boulch, Philippe Bousso / Institut Pasteur

Read the press release: Immunothérapies des cancers du sang : mise en évidence de la destruction à distance des cellules cancéreuses