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© Emeline Camand
Marquage par immunofluorescence d'astrocytes tumoraux ou astrocytomes (lignée cellulaire humaine U373), montrant en rouge, APC et en vert, la tubuline des microtubules. APC est un supresseur de tumeur qui est impliqué dans la polarisation des astrocytes normaux. La localisation d'APC est altérée dans des lignées de gliomes. Pour essayer de corriger, les dérèglements observés lors de la migration des cellules d'astrocytes tumuraux ou gliomes on cherche à connaitre les mécanismes moléculaires fondamentaux qui controlent la polarisation et la migration cellulaire.
Project

Reorganization of cytoskeletal elements and cell migration – Perturbation of the regulation of cytoskeletal networks in glioblastoma cells

Scientific Fields
Diseases
Organisms
Applications
Technique
Starting Date
18
May 2015
Status
Ongoing
Members
1
Structures
1

About

How are cytoskeletal elements reorganized to promote cell migration? Is the regulation of the cytoskeletal networks perturbed in glioblastoma cells?

  • We have shown that the three main cytoskeletal networks, microfilaments, microtubules and intermediate filaments act in concert to promote astrocyte migration(Etienne-Manneville, Ann Rev Cell Dev Biol 2013).
  • We have demonstrated the role of the tumor suppressor polarity proteins, such as APC and Dlg1, in the rearrangements of the microtubule network (Manneville, Jehanno et al., 2010).
  • We have shown that APC directly interacts with intermediate filaments and forms a molecular bridge between microtubules and intermediate filaments to promote the parallel and polarized organization of the two cytoskeletal elements (Sakamoto et al. 2013).

Current work focuses on the role of post translational modifications in microtubule regulation and on the regulation of intermediate filament dynamics and functions during astrocyte and glioblastoma cell migration.