Projects Project Ongoing 9 Members Antibiotic resistances and drug screening Brigitte Gicquel (PI) An alarming number of multidrug resistant (MDR) and extremely drug resistant (XDR) tuberculosis are found in different countries with high demography like India and China. In eastern Europe the highest incidence of MDR tuberculosis […] Project Completed 7 Members Nanotherapeutics for Antibiotic Resistant Emerging Bacterial pathogens Brigitte Gicquel (PI) The NAREB project: Nanotherapeutics for Antibiotic Resistant Emerging Bacterial pathogens The extensive use of antimicrobials in human medicine over the past 70 years has now led to a major threat to clinical practice due […] Project Completed 4 Members The two-component system PhoP/PhoQ Brigitte Gicquel (PI) Two-component regulatory proteins function in bacteria as sensory and adaptive factors in response to a wide range of environmental stimuli. Some two-component systems, such as PhoP/PhoQ, control the transcription of key virulence genes in […]
Publications Download 2020 Coulibaly S, Cimino M, Ouattara M, Lecoutey C, Buchieri MV, Alonso-Rodriguez N, Briffotaux J, Mornico D, Gicquel B, Rochais C, Dallemagne P, , Phenanthrolinic analogs of quinolones show antibacterial activity against M. tuberculosis., Eur J Med Chem 2020 Sep; 207(): 112821. 2017 Buchieri MV, Cimino M, Rebollo-Ramirez S, Beauvineau C, Cascioferro A, Favre-Rochex S, Helynck O, Naud-Martin D, Larrouy-Maumus G, Munier-Lehmann H, Gicquel B, Nitazoxanide Analogs Require Nitroreduction for Antimicrobial Activity in Mycobacterium smegmatis, J. Med. Chem. 2017 Sep 14;60(17):7425-7433.