Born and bred in Alsace, France, I did my PhD at the Institut de Biologie Moleculaire et Cellulaire of Strasbourg, in the laboratory of Prof. Jules Hoffmann under the supervision of Dr. Dominique Ferrandon. I investigated the host-pathogen interaction between the insect Drosophila melanogaster and different human fungal pathogens. As a continuation, I pursued my Post-Doctoral research in the group headed by Prof. Mihai Netea (Radboud University, Nijmegen, The Netherlands) and deciphered the host immune system strategies of mammals (using murine models but also human tissues) required to effectively fight life threatening systemic candidiasis. I then went back to France to start my own group in the Institut Pasteur.
β-glucan imprinting of macrophages
The enhanced responsiveness observed in human monocytes and mediated by β‑glucan priming is directed towards several other pathogens that are not obligatory fungal-related. This enhanced responsiveness coined training is translated by increased pro-inflammatory cytokines […]
β-glucan regulation of innate host defence
β-glucan, the most abundant fungal cell wall polysaccharide in C. albicans, has gained much attention from the scientific community in the last few decades for its fascinating but not yet fully understood immunobiology. Study […]
Innate immunological imprinting induced by fungal encounters
The immune system is composed of two arms: the innate and adaptive immunity. Until recently, the adaptive immune system was considered the only mediator of immune memory. However, we and others demonstrated that innate […]
PTR66-2017 Role of Toll-Like and Nod-Like Receptors in the activation and functions of phagocytes infected with pathogenic Leptospira
We showed that Leptospira escape recognition by some innate immune receptors of the Toll-like (TLR) and Nod-Like families (NLR). We wonder whether this escape is responsible for the deficient phagocytic activity towards leptospires or […]
EDUCATION/TRAINING 2004 – 2005: Master in molecular and cellular biology University Louis Pasteur, Strasbourg, France. 2005 – 2009: PhD in Molecular and Cellular Biology, Université de Strasbourg, France. Laboratory RIDI of Prof. Dr. Jules Hoffman. POSITIONS 2005 – 2009: PhD in Molecular and Cellular Biology «Immune Response and Development in Insects», CNRS (UPR 9022), Strasbourg, France 2010 – 2015: Post-Doctorate fellow, «Experimental Internal Medicine» Radboudumc, Nijmegen, The Netherlands. 2015 – present: Young Principal Investigator at Institut Pasteur, Paris, France Head of the Immunology of Fungal Infections group Department of Mycology OTHER COMMITMENTS 2015 – present: Member of the bureau (2018) and scientific steering committee of the Centre de Bioinformatique, Biostatistique et Biologie Intégrative (C3Bi, Institut Pasteur)
2020β-Glucan-induced reprogramming of human macrophages inhibits NLRP3 inflammasome activation in cryopyrinopathies., J Clin Invest 2020 09; 130(9): 4561-4573.
2019Studying fungal pathogens of humans and fungal infections: fungal diversity and diversity of approaches, Genes Immun. 2019 05;20(5):403-414.
2018Fungal mediated innate immune memory, what have we learned?, Semin. Cell Dev. Biol. 2018 May;.
2018The Complexity of Fungal β-Glucan in Health and Disease: Effects on the Mononuclear Phagocyte System, Front Immunol 2018;9:673.
2018Impaired phagocytosis directs human monocyte activation in response to fungal derived β-glucan particles, Eur. J. Immunol. 2018 May;48(5):757-770.
2017Microglial Priming as Trained Immunity in the Brain, Neuroscience 2017 Dec;.
2016Cell Wall Changes in Amphotericin B-Resistant Strains from Candida tropicalis and Relationship with the Immune Responses Elicited by the Host, Antimicrob. Agents Chemother. 2016 Apr;60(4):2326-35.
2016Fungal Chitin Induces Trained Immunity in Human Monocytes during Cross-talk of the Host with Saccharomyces cerevisiae, J. Biol. Chem. 2016 Apr;291(15):7961-72.
2016The Role of Dectin-2 for Host Defense Against Disseminated Candidiasis, J. Interferon Cytokine Res. 2016 Apr;36(4):267-76.
2015Of mice, flies–and men? Comparing fungal infection models for large-scale screening efforts, Dis Model Mech 2015 May;8(5):473-86.
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