Hiroshi Sakamoto joined the Pasteur Institute in 1984 right after his PhD defense in Microbiology. The first half of his career was dedicated to academic research in the field of bacterial pathogens, as well as related aspects of molecular biotechnology. He then switched his interest into more sophisticated host-pathogen interaction systems, and focused in challenging molecular issues of malaria genomics. He recently joined Magnus Fontes’s IGDA team, where he promotes dialog between biology and informatics within the INDA network.