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MECHANISMS OF DNA RECOMBINATION
Ludovic Deriano (PI)
DNA double-strand breaks (DSBs), although common, are extremely dangerous (Deriano and Roth, Annual Review of Genetics, 2013). Unlike most other DNA lesions, DSBs directly threaten genomic integrity by disrupting the physical continuity of […]
2022SHLD1 is dispensable for 53BP1-dependent V(D)J recombination but critical for productive class switch recombination., Nat Commun 2022 Jun; 13(1): 3707.
2020Repair of G1 induced DNA double-strand breaks in S-G2/M by alternative NHEJ., Nat Commun 2020 Oct; 11(1): 5239.
2016Synthetic lethality between PAXX and XLF in mammalian development, Genes Dev. 2016 Oct 1;30(19):2152-2157..
2016Specific Roles of XRCC4 Paralogs PAXX and XLF during V(D)J Recombination, Cell Rep. 2016 Sep 13;16(11):2967-79. doi: 10.1016/j.celrep.2016.08.069. Epub 2016 Sep 2..